Abstract
The diagnosis of pituitary disorders is difficult because several hormone systems are involved. The clinical presentation is often vague and slowly progressing, and clinicians therefore have to rely very much on correct biochemical measurements. This is also associated with difficulties since the pituitary hormones interact, the binding proteins are influenced by the other axes and a variety of other effects, and finally the hormone measurements in serum are not totally adequate Several studies have investigated the interaction between the thyroid and growth hormone axes with very variable results. The present review is focussing on the aspects related to clinical decision making based on biochemical assessments. Because of the strong and sometimes unpredictable interrelations between the hypothalamo-pituitary thyroid and the hypothalamo-GHIGF axes, and the many pitfalls in the measurement of peripheral hormones and interpretation of stimulation tests, clinicians and clinical biochemists should collaborate closely. Only then can the diagnostic accuracy and the management of patients with both growth hormone and thyroid disorders be improved.
Keywords: Growth hormone, acromegaly, thyroid function, growth hormone deficiency, thyroid diseases, deiodinase
Current Medicinal Chemistry
Title: Interactions Between Growth Hormone and the Thyroid Gland - with Special Reference to Biochemical Diagnosis
Volume: 14 Issue: 26
Author(s): Ulla Feldt-Rasmussen
Affiliation:
Keywords: Growth hormone, acromegaly, thyroid function, growth hormone deficiency, thyroid diseases, deiodinase
Abstract: The diagnosis of pituitary disorders is difficult because several hormone systems are involved. The clinical presentation is often vague and slowly progressing, and clinicians therefore have to rely very much on correct biochemical measurements. This is also associated with difficulties since the pituitary hormones interact, the binding proteins are influenced by the other axes and a variety of other effects, and finally the hormone measurements in serum are not totally adequate Several studies have investigated the interaction between the thyroid and growth hormone axes with very variable results. The present review is focussing on the aspects related to clinical decision making based on biochemical assessments. Because of the strong and sometimes unpredictable interrelations between the hypothalamo-pituitary thyroid and the hypothalamo-GHIGF axes, and the many pitfalls in the measurement of peripheral hormones and interpretation of stimulation tests, clinicians and clinical biochemists should collaborate closely. Only then can the diagnostic accuracy and the management of patients with both growth hormone and thyroid disorders be improved.
Export Options
About this article
Cite this article as:
Feldt-Rasmussen Ulla, Interactions Between Growth Hormone and the Thyroid Gland - with Special Reference to Biochemical Diagnosis, Current Medicinal Chemistry 2007; 14 (26) . https://dx.doi.org/10.2174/092986707782360114
DOI https://dx.doi.org/10.2174/092986707782360114 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Dual Inhibitors of Monoamine Oxidase and Cholinesterase for the Treatment of Alzheimer Disease
Current Topics in Medicinal Chemistry Arsenic Immunotoxicity and Immunomodulation by Phytochemicals: Potential Relations to Develop Chemopreventive Approaches
Recent Patents on Inflammation & Allergy Drug Discovery Revising Skin Cancers by Means of Epigenetic Markers
Recent Patents on Biomarkers Characterization of Proteins from Putative Human DNA and RNA Viruses
Current Proteomics Endothelin-1 and Endothelin Converting Enzyme-1 in Human Atherosclerosis - Novel Targets for Pharmacotherapy in Atherosclerosis
Current Vascular Pharmacology Potential Role of Acrolein in Neurodegeneration and in Alzheimers Disease
Current Molecular Pharmacology Receptor-Based Design of Cytokine Therapeutics
Current Pharmaceutical Biotechnology Metal Complexes, their Cellular Targets and Potential for Cancer Therapy
Current Pharmaceutical Design Protein Folding and Misfolding, Endoplasmic Reticulum Stress in Neurodegenerative Diseases: in Trace of Novel Drug Targets
Current Protein & Peptide Science Sleep and Asthma
Current Respiratory Medicine Reviews Mining for Protein Kinase Substrates: Integration of Biochemistry, Genetics and Proteomics
Current Proteomics Role of the Sympathetic Nervous Activity in Hypertension-Update in 2013
Current Hypertension Reviews Subclassification and Nomenclature of α- and β-Adrenoceptors
Current Topics in Medicinal Chemistry The Lung Disease of Rheumatoid Arthritis
Current Respiratory Medicine Reviews Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
Current Medicinal Chemistry Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: Potential Pathogenic Role and Link to Oxidative Damage
Current Alzheimer Research Strategies for Rot Control of Soybean Sprouts
Recent Patents on Food, Nutrition & Agriculture Interventions to Reduce Cardiovascular Risk in Children with Type 1 Diabetes
Current Diabetes Reviews Antagonizing the Calcium-Sensing Receptor: Towards New Bone Anabolics?
Current Molecular Pharmacology Targeted Therapy for Advanced Renal Cell Cancer: Cytokines and Beyond
Current Pharmaceutical Design