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Human Exposure to Polychlorinated Biphenyls and Health Effects

A Critical Synopsis

  • Review Article
  • Published:
Toxicological Reviews

Abstract

Polychlorinated biphenyls (PCBs) are a mixture of chemicals. Some congeners of the mixture are highly persistent both in the environment and in humans. Although PCBs have not been used commercially since about 1977 in the US, they can still be detected in human blood and tissues in this country. PCB levels are declining and are often no longer detectable in younger people. A cursory review of recent animal studies is provided. Studies to determine whether PCBs cause cancer in humans, neurobehavioural effects, abnormal thyroid and immune function in children and low birth weight are discussed in more detail. These studies are inconclusive and do not provide clinical evidence that PCBs at levels encountered with human exposure produce adverse health effects. The differences in PCB blood or tissue concentrations between controls and cases, or between the upper and lower end of various environmentally exposed groups of children or adults, are small. Although some effects are statistically significantly different, they do not appear to be biologically significant. Many studies on the effects of PCBs are difficult to interpret because the range of normal values for clinical and neurobehavioural tests are not provided or appropriately considered, there was no, or inadequate, control for potential confounders. In occupational mortality studies, exposures were much higher. In some studies, various specific cancers were elevated. However, these appear to be chance observations resulting from multiple comparisons since the increase of specific cancers was not consistent between studies and was no longer present in some cohorts when studies were repeated at a later date with longer follow-up. Overall, the data fail to demonstrate conclusive adverse health effects of PCBs at concentrations encountered with human exposures.

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References

  1. Kimbrough RD. Polychlorinated biphenyls (PCBs) and human health: an update. Crit Rev Toxicol 1995; 25: 133–63

    Article  PubMed  CAS  Google Scholar 

  2. Kimbrough RD. The toxicity of polychlorinated polycyclic compounds and related chemicals. CRC Crit Rev Toxicol 1987; 4: 445–98

    Google Scholar 

  3. Kimbrough RD, Jensen AA, editors. Halogenated biphenyls, terphenyls, naphthalenes, dibenozdioxins and related compounds. Amsterdam: Elsevier/North Holland Biomedical Press, 1989

    Google Scholar 

  4. Cogliano VJ. Assessing the cancer risk from environmental PCBs. Environ Health Perspect 1998; 106: 317–23

    Article  PubMed  CAS  Google Scholar 

  5. Kimbrough RD, Krouskas CA. Polychlorinated biphenyls, dibenzo-p-dioxins, and dibenzofurans and birth weight and immune and thyroid function in children. Regul Toxicol Pharmacol 2001; 34: 42–52

    Article  PubMed  CAS  Google Scholar 

  6. Kimbrough RD, Doemland ML, Krouskas CA. Analysis of research studying the effects of polychlorinated biphenyls and related chemicals on neurobehavioral development in children. Vet Hum Toxicol 2001; 43: 220–8

    PubMed  CAS  Google Scholar 

  7. Longnecker MP, Rogan WJ, Lucier G. The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBs (polychlorinated biphenyls) and an overview of organochlorines in public health. Annu Rev Public Health 1997; 18: 211–44

    Article  PubMed  CAS  Google Scholar 

  8. Seegal RF. Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit Rev Toxicol 1996; 26: 709–37

    Article  PubMed  CAS  Google Scholar 

  9. Tilson HA, Jacobson JL, Rogan WJ. Polychlorinated biphenyls and the developing nervous system: cross-species comparison. Neurotoxicol Teratol 1990; 12: 239–48

    Article  PubMed  CAS  Google Scholar 

  10. Tilson HA, Prasada RS, Kodavanti WR, et al. Neurotoxicity of environmental chemicals and their mechanism of action. Toxicol Lett 1998; 102–103: 631–5

    Article  PubMed  Google Scholar 

  11. Schantz SL, Widholm JJ, Rice DC. Effects of PCB exposure on neuropsychological function in children. Environ Health Perspect 2003; 111: 1–20

    Article  CAS  Google Scholar 

  12. Schell Jr JD, Budinsky RA, Wernke MJ. PCBs and neurodevelopmental effects in Michigan children: an evaluation of exposure and dose characterization. Regul Toxicol Pharmacol 2001; 33: 300–12

    Article  PubMed  CAS  Google Scholar 

  13. US Department of Health and Human Services. Public Health Service. Agency for Toxic Substances and Disease Registry. Toxic profile for polychlorinated biphenyls (update). 2000 Nov. NTIS PB 2000 108027

  14. Ribas-Fitó N, Sala M, Kogevinas M, et al. Polychlorinated biphenyls (PCBs) and neurological development in children: a systemic review. J Epidemiol Community Health 2001; 55: 537–46

    Article  PubMed  Google Scholar 

  15. US EPA. Polychlorinated biphenyls (PCBs): manufacturing, processing, distribution in commerce and use prohibitions: use in electrical equipment. Fed Regist 1982; 47: 37–342

    Google Scholar 

  16. Ballschmiter K, Rappe C, Buser HR. Chemical properties, analytical methods and environmental levels of PCBs, PCTs, PCNs and PBBs. In: Kimbrough RD, Jensen AA, editors. Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products. Amsterdam: Elsevier Biomedical Press, 1989: 47–69

    Chapter  Google Scholar 

  17. Ballschmiter K, Niemczyk R, Schäfer W, et al. Isomer specific identification of polychlorinated benzenes (PCBz) and -biphenyls (PCBs) in effluents of municipal waste incineration. Fresenius Z Anal Chem 1987; 328: 583–7

    Article  CAS  Google Scholar 

  18. Linder RE, Gaines TB, Kimbrough RD. The effect of polychlorinated biphenyls on rat reproduction. Food Cosmet Toxicol 1974; 12: 63–77

    Article  PubMed  CAS  Google Scholar 

  19. Cecil HC, Bitman RJ, Fries GF, et al. Embryotoxic and teratogenic effects in unhatched fertile eggs from hens fed polychlorinated biphenyls (PCBs). Bull Environ Contam Toxicol 1974; 11: 489–95

    Article  PubMed  CAS  Google Scholar 

  20. Barsotti DA, Marlar RJ, Allen JR. Reproductive dysfunction in rhesus monkeys exposed to low levels of polychlorinated biphenyls (Aroclor 1248). Food Cosmet Toxicol 1976; 14: 99–103

    Article  PubMed  CAS  Google Scholar 

  21. Allen JR, Barsotti DA. The effects of transplacental and mammary movement of PCBs on infant rhesus monkeys. Toxicology 1976; 6: 331–40

    Article  PubMed  CAS  Google Scholar 

  22. Bowman RE, Heironimus MP, Allen JR. Correlation of PCB body burden with behavioral toxicology in monkeys. Pharmacol Biochem Behav 1978; 9: 49–56

    Article  PubMed  CAS  Google Scholar 

  23. Arnold DL, Bryce F, Stapley R, et al. Toxicological consequences of Aroclor 1254 ingestion by female rhesus (Macaca mulatto) monkeys. Part 1A. Prebreeding phase: clinical health findings. Food Chem Toxicol 1993; 31: 799–810

    Article  PubMed  CAS  Google Scholar 

  24. Arnold DL, Bryce F, Mcquire PF, et al. Toxicological consequences of Aroclor 1254 ingestion by female rhesus monkeys (Macaca mulatta). Part 2. Reproduction and infant findings. Food Chem Toxicol 1995; 33: 457–74

    Article  PubMed  CAS  Google Scholar 

  25. Mes J, Arnold DL, Bryce F. Postmortem tissue levels of polychlorinated biphenyls in female rhesus monkeys after more than six years of daily dosing with Aroclor 1254 and in their non-dosed offspring. Arch Environ Contam Toxicol 1995; 29: 69–76

    Article  PubMed  CAS  Google Scholar 

  26. Seegal RF, Bush B, Brosch KO. Subchronic exposure of the adult rat to Aroclor 1254 yields regionally specific changes in central dopaminergic function. Neurotoxicology 1991; 12: 55–66

    PubMed  CAS  Google Scholar 

  27. Seegal RF, Bush B, Shain W. Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in non-human primate brain and in tissue culture. Toxicol Appl Pharmacol 1990; 106: 136–44

    Article  PubMed  CAS  Google Scholar 

  28. Seegal RF, Bush B, Brosch KO. Comparison of effects of Aroclor 1016 and 1260 on non-human primate catecholamine function. Toxicology 1991; 66: 145–63

    Article  PubMed  CAS  Google Scholar 

  29. Morse DC, Klasson Wehler E, Wesseling W, et al. Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254). Toxicol Appl Pharmacol 1996; 136: 269–79

    Article  PubMed  CAS  Google Scholar 

  30. Barter RA, Klaassen CD. Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronyl transferase inducers in rats. Toxicol Appl Pharmacol 1994; 128: 9–17

    Article  PubMed  CAS  Google Scholar 

  31. Goldey ES, Crofton KM. Thyrtoxine replacement attentuates hypothyroxinemia, hearing loss and motor deficits following developmental exposure to Aroclor 1254 in rats. Toxicol Sci 1998; 45: 94–105

    PubMed  CAS  Google Scholar 

  32. Desaulniers D, Leingartner K, Wade M, et al. Effects of acute exposure to PCBs 126 and 153 on anterior pituitary and thyroid hormones and FSH isoforms in adult Sprague-Daley male rats. Toxicol Sci 1999; 47: 158–69

    Article  PubMed  CAS  Google Scholar 

  33. Safe S. PCBs as aryl hydrocarbon receptor agonists: implications for risk assessment. In: Robertson LW, Hansen LG editors. PCBs recent advances in environmental toxicology and health effects. Lexington (KY): The University Press of Kentucky, 2001: 171–7

    Google Scholar 

  34. Ito N, Nagasaki H, Arai M, et al. Histopathologic studies on liver tumorigenesis in mice by technical polychlorinated biphenyls and its promoting effect on liver tumors induced by benzene hexachloride. J Natl Cancer Inst 1973; 51: 1637–46

    PubMed  CAS  Google Scholar 

  35. Kimbrough RD, Squire RA, Linder RE, et al. Induction of liver tumors in Sherman strain female rats by polychlorinated biphenyl Aroclor 1260. J Natl Cancer Inst 1975; 55: 1453–9

    PubMed  CAS  Google Scholar 

  36. Schäffer E, Greim H, Gössner W. Pathology of chronic polychlorinated biphenyl (PCB) feeding in rats. Toxicol Appl Pharmacol 1984; 75: 278–88

    Article  Google Scholar 

  37. Norback DH, Weltmann RH. Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Daley rat. Environ Health Perspect 1985; 60: 97–105

    Article  PubMed  CAS  Google Scholar 

  38. National Cancer Institute. NCI bioassay of Aroclor 1254 for possible carcinogenicity 1978 NC-GC-TR-38. Bethesda (MD): National Cancer Institute, 1978. NTIS PB279624

    Google Scholar 

  39. Mayes BA, McConnell EE, Neal BH, et al. Comparative carcinogenicity in Sprague-Daley rats of the polychlorinated biphenyl mixtures Aroclor 1016, 1242, 1254 and 1260. Toxicol Sci 1998; 41: 62–76

    PubMed  CAS  Google Scholar 

  40. US Environmental Protection Agency. Guidelines for carcinogen risk assessment. Fed Regist 1986; 51: 34014–25

    Google Scholar 

  41. Albert RE. Carcinogen risk assessment in the US Environmental Protection Agency. Crit Rev Toxicol 1994; 24: 75–85

    Article  PubMed  CAS  Google Scholar 

  42. Frame GM. The current state-of-the-art of comprehensive quantitative congener-specific PCB analysis, and what we now know about the distributions of individual congeners in commercial Aroclor mixtures. In: Robertson LW, Hansen LG, editors. PCBs recent advances in environmental toxicology and health effects. Lexington (KY): The University Press of Kentucky, 2001: 3–9

    Google Scholar 

  43. Patandin S, Koopman-Esseboom C, de Ridder MAJ, et al. Effects of environmental exposure to polychlorinated biphenyls and dioxins on birth size and growth in Dutch children. Pediatr Res 1998; 44: 538–45

    Article  PubMed  CAS  Google Scholar 

  44. Dar E, Kanarek MS, Anderson HA, et al. Fish consumption and reproductive outcomes in Green Bay, Wisconsin. Environ Res 1992; 59: 189–201

    Article  PubMed  CAS  Google Scholar 

  45. Safe S, Safe L, Mullin M. Polychlorinated biphenyls: Congener-specific analysis of a commercial mixture and a human milk extract. J Agric Food Chem 1985; 33: 24–9

    Article  CAS  Google Scholar 

  46. Ballschmiter K, Zell M. Analysis of polychlorinated biphenyl (PCB) by glass capillary gas chromatography: composition of technical Aroclor and Clophen-PCB mixtures. Fresensius Z Anal Chem 1980; 302: 20–31

    Article  CAS  Google Scholar 

  47. Hansen LG. Identification of steady state and episodic PCB congeners from multiple pathway exposures. In: Robertson LW, Hansen LG, editors. PCBs recent advances in environmental toxicology and health effects. Lexington (KY): The University Press of Kentucky, 2001: 47–53

    Google Scholar 

  48. Eisenreich SJ, Baker JE, Franz T, et al. Atmospheric deposition of hydrophobic organic contaminants to the Laurentian Great Lakes. In: Schnoor JL, editor. Fate of pesticides and chemicals in the environment. New York (NY): John Wiley & Sons Inc, 1992: 51–78

    Google Scholar 

  49. Hansen LG. The ortho side of PCBs: occurrence and disposition. Boston (MA): Kluwer Academic Publishers, 1999

    Book  Google Scholar 

  50. Matthews HB, Dedrick RL. Pharmacokinetics of PCBs. Ann Rev Pharmacol Toxicol 1984; 24: 85–103

    Article  CAS  Google Scholar 

  51. Kato S, McKinney JD, Matthews HB. Metabolism of symmetrical hexachlorobiphenyl isomers in the rat. Toxicol Appl Pharmacol 1980; 53: 389–98

    Article  PubMed  CAS  Google Scholar 

  52. Chen PH, Luo ML, Wong CK, et al. Comparative rates of elimination of some individual polychlorinated biphenyls from the blood of PCB-poisoned patients in Taiwan. Food Chem Toxicol 1982; 20: 417–25

    Article  PubMed  CAS  Google Scholar 

  53. Bühler F, Schmid P, Schlatter CH. Kinetics of PCB elimination. Chemosphere 1988; 17: 1717–26

    Article  Google Scholar 

  54. Phillips DL, Smith AB, Burse VW. Half-life of polychlorinated biphenyls in occupationally exposed workers. Arch Environ Health 1989; 44: 351–4

    Article  PubMed  CAS  Google Scholar 

  55. Brown Jr JF, Lawton RW. Factors controlling distribution and levels of PCBs after occupational; exposure. In: Robertson LW, Hansen LG, editors. PCBs recent advances in environmental toxicology and health effects. Lexington (KY): The University Press of Kentucky, 2001: 103–9

    Google Scholar 

  56. US EPA. Interim procedures for estimating risks associated with exposures to mixtures of chlorinated dibenzo-p-dioxins and dibenzofurans (CDDs and CDFs): an 1989 update. Washington, DC: US Environmental Protection Agency, 1989. EPA/625/3-89/016

    Google Scholar 

  57. Van den Berg M, Birnbaum L, Bosveld ATC, et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs and PCDFs for humans and wild life. Environ Health Perspect 1998; 106: 775–92

    Article  PubMed  Google Scholar 

  58. Starr TB, Greenlee WF, Neal RA, et al. The trouble with TEFs. Environ Health Perspect 1999; 107: A492

    Article  PubMed  CAS  Google Scholar 

  59. Neubert D, Golor G, Hagenmaier H. Toxic TCDD-equivalents, problems and applicability for risk assessment: health effects and safety assessment of dioxins and furans. The Toxicology Forum conference proceedings; Jan 15–17; Karlsruhe, Germany, 1990: 560

  60. Dean CE, Benjamin SA, Chubb LS, et al. Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers. Toxicol Sci 2002; 66: 54–61

    Article  PubMed  CAS  Google Scholar 

  61. Andersen HA. General population exposure to environmental concentrations of halogenated biphenyls. In: Kimbrough RD, Jensen AA, editors. Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products. Amsterdam: Elsevier North-Holland Biomedical Press, 1989: 325–44

    Chapter  Google Scholar 

  62. Hovinga ME, Sowers M, Humphrey HEB. Historical changes in serum PCB and DDT levels in an environmentally exposed cohort. Arch Environ Contam Toxicol 1992; 22: 362–6

    Article  PubMed  CAS  Google Scholar 

  63. Kreiss K, Zack MM, Kimbrough RD, et al. Association of blood pressure and polychlorinated biphenyl levels in a cross-sectional community study. JAMA 1981; 245: 2505–9

    Article  PubMed  CAS  Google Scholar 

  64. Lawton RW, Ross MR, Feingold J, et al. Effects of PCB exposure on biochemical and hematological findings in capacitor workers. Environ Health Perspect 1985; 60: 165–84

    Article  PubMed  CAS  Google Scholar 

  65. Maroni M, Colombi A, Arbosti G, et al. Occupational exposure to polychlorinated biphenyls in electrical workers II: health effects. Br J Ind Med 1981; 38: 55–60

    PubMed  CAS  Google Scholar 

  66. Colombi A, Maroni M, Ferioli A, et al. Increase in urinary porphyrin excretion in workers exposed to polychlorinated biphenyls. J Appl Toxicol 1982; 2: 115–21

    Article  Google Scholar 

  67. Hill R, Bailey SL, Needham LL. Development and utilization of a procedure for measuring urinary porphyrins by high performance liquid chromatography. J Chromatogr 1982; 232: 251–60

    Article  PubMed  CAS  Google Scholar 

  68. Smith AB, Schloemer J, Lowry J, et al. Metabolic and health consequences of occupational exposure to polychlorinated biphenyls. Br J Ind Med 1982; 39: 361–9

    PubMed  CAS  Google Scholar 

  69. Meigs JW, Albom JJ, Kartin BL. Chloracne from an unusual exposure to Aroclor. JAMA 1954; 154: 1417–8

    Article  CAS  Google Scholar 

  70. Ouw HK, Simpson GR, Siyali DS. Use and health effects of Arclor 1242 a polychlorinated biphenyl in an electrical industry. Arch Environ Health 1976; 31: 189–94

    PubMed  CAS  Google Scholar 

  71. Elo O, Vuojolahti P, Janhunen H, et al. Recent PCB accidents in Finland. Environ Health Perspect 1985; 60: 315–9

    Article  PubMed  CAS  Google Scholar 

  72. Fischbein A, Wolff MS, Lillis R, et al. Clinical findings among PCB exposed capacitor manufacturing workers. N Y Acad Sci 1979; 320: 703–15

    CAS  Google Scholar 

  73. Warshaw R, Fishbein A, Thornton J, et al. Decrease in vital capacity in PCB-exposed workers in a capacitor manufacturing facility. N Y Acad Sci 1979; 320: 277–83

    CAS  Google Scholar 

  74. Fischbein A, Rizzo JN, Solomon SJ, et al. Oculodermatological findings in workers with occupational exposure to polychlorinated biphenyls (PCBs). Br J Ind Med 1985; 42: 426–30

    PubMed  CAS  Google Scholar 

  75. Jones JW, Alden HS. An acneform dermatogosis. AMA Arch Derm Syphilol 1936; 33: 1022–34

    Article  CAS  Google Scholar 

  76. Brown DP, Jones J. Mortality and industrial hygiene study of workers exposed to polychlorinated biphenyls. Arch Environ Health 1981; 36: 120–9

    PubMed  CAS  Google Scholar 

  77. Brown DP. Mortality of workers exposed to polychlorinated biphenyls: an update. Arch Environ Health 1987; 42: 333–9

    Article  PubMed  CAS  Google Scholar 

  78. Taylor PR. The health effects of polychlorinated biphenyls (doctoral thesis). Boston (MA): Harvard School of Public Health, 1988

    Google Scholar 

  79. Kimbrough RD, Doemland ML, LeVois ME. Mortality in male and female capacitor workers exposed to polychlorinated biphenyls. J Occup Environ Med 1999; 41: 161–71

    Article  PubMed  CAS  Google Scholar 

  80. Kimbrough RD, Doemland ML, Mandel JS. A mortality update of male and female capacitor workers exposed to polychlorinated biphenyls. J Occup Environ Med 2003; 45: 271–82

    Article  PubMed  CAS  Google Scholar 

  81. Howe HL, Wingo PA, Thun MJ, et al. Annual report to the nation on the status of cancer (1973-1998) featuring cancers with recent increasing trends. J Natl Cancer Inst 2001; 93: 824–42

    Article  PubMed  CAS  Google Scholar 

  82. Schottenfeld D, Winawer SJ. Cancers of the large intestines. In: Schottenfeld D, Fraumeni JF, editors. Cancer, epidemiology, prevention. 2nd ed. New York: Oxford University Press, 1996: 813–40

    Google Scholar 

  83. Bertazzi PA, Riboldi L, Pesatori A, et al. Cancer mortality of capacitor manufacturing workers. Am J Ind Med 1987; 11: 165–76

    Article  PubMed  CAS  Google Scholar 

  84. Tironi A, Pesatori A, Consonni D, et al. Mortalitadi Lavoratrici exposte a PCB. Epidemiol Prev 1996; 20: 200–3

    PubMed  CAS  Google Scholar 

  85. Sinks T, Steele G, Smith A, et al. Mortality among workers exposed to polychlorinated biphenyls. Am J Epidemiol 1992; 136: 389–98

    PubMed  CAS  Google Scholar 

  86. Yassi A, Tate R, Fish D. Cancer mortality in workers employed at a transformer manufacturing plant. Am J Ind Med 1994; 25: 425–37

    Article  PubMed  CAS  Google Scholar 

  87. Yassi A, Tate RB, Routledge M. Cancer incidence and mortality in workers employed at a transformer manufacturing plant: update to a cohort study. Am J Ind Med 2003; 44: 58–62

    Article  PubMed  Google Scholar 

  88. Gustavsson P, Hogstedt C, Rappe C. Short term mortality and cancer incidence in capacitor manufacturing workers exposed to polychlorinated biphenyls. Am J Ind Med 1986; 10: 341–4

    Article  PubMed  CAS  Google Scholar 

  89. Gustavsson P, Hogstedt C. A cohort study of Swedish capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Am J Ind Med 1997; 32: 234–9

    Article  PubMed  CAS  Google Scholar 

  90. Loomis D, Browning SR, Schenk AP, et al. Cancer mortality among electric utility workers exposed to polychlorinated biphenyls. Occup Environ Med 1997; 54: 720–8

    Article  PubMed  CAS  Google Scholar 

  91. Bahn AK, Grover P, Rosenwaike I, et al. Melanoma after exposure to PCBs [letter]. N Engl J Med 1977; 295: 450

    Google Scholar 

  92. Adami HO, Lipsworth L, Titus-Ernstoff L, et al. Organochlorine compounds and estrogen related cancers in women. Cancer Causes Control 1995; 6: 551–66

    Article  PubMed  CAS  Google Scholar 

  93. Aronson KJ, Miller AB, Wollcott CG, et al. Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2000; 9: 55–63

    PubMed  CAS  Google Scholar 

  94. Aschengrau A, Coogan PF, Quinn M, et al. Occupational exposure to estrogenic chemicals and the occurrence of breast cancer: an exploratory analysis. Am J Ind Med 1998; 34: 6–14

    Article  PubMed  CAS  Google Scholar 

  95. Demers A, Ayotte P, Brisson J, et al. Risk and aggressiveness of breast cancer in relation to plasma organochlorine concentrations. Cancer Epidemiol Biomarkers Prev 2000; 9: 161–6

    PubMed  CAS  Google Scholar 

  96. Demers A, Ayotte P, Brisson J, et al. Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener specific analysis. Am J Epidemiol 2002; 155: 629–35

    Article  PubMed  Google Scholar 

  97. Dorgan JF, Brock JW, Rothman N, et al. Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA). Cancer Causes Control 1999; 10: 1–11

    Article  PubMed  CAS  Google Scholar 

  98. Falck Jr F, Ricci Jr A, Wolff MS, et al. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health 1992; 47: 143–6

    PubMed  Google Scholar 

  99. Gammon MD, Wolff MS, et al. Treatment for breast cancer and blood levels of chlorinated hydrocarbons. Cancer Epidemiol Biomarkers Prev 1996; 5: 467–71

    PubMed  CAS  Google Scholar 

  100. Gammon MD, Wolff MS, Neugut AI, et al. Environmental toxins and breast cancer on Long Island II: organochlorine compounds in blood. Cancer Epidemiol Biomarkers Prev 2002; 11: 686–97

    PubMed  CAS  Google Scholar 

  101. Guttes S, Failing K, Neumann K, et al. Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease. Arch Environ Contam Toxicol 1998; 35: 140–7

    Article  PubMed  CAS  Google Scholar 

  102. Helzlsouer KJ, Alberg AJ, Huang HY, et al. Serum concentrations of organochlorine compounds and the subsequent development of breast cancer. Cancer Epidemiol Biomarkers Prev 1999; 8: 525–32

    PubMed  CAS  Google Scholar 

  103. Holford TR, Zheng T, Mayne ST, et al. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. Int J Epidemiol 2000; 29: 975–82

    Article  PubMed  CAS  Google Scholar 

  104. Hoyer AP, Grandjean P, Jorgensen TT, et al. Organochlorine exposure and risk of breast cancer. Lancet 1998; 352: 1816–20

    Article  PubMed  CAS  Google Scholar 

  105. Hoyer AP, Jorgensen TT, Grandjean PM, et al. Repeated measurements of organochlorine and breast cancer risk. Cancer Causes Control 2000; 11: 177–84

    Article  PubMed  CAS  Google Scholar 

  106. Hoyer AP, Jorgensen T, Brock JW, et al. Organochlorine exposure and breast cancer survival. J Clin Epidemiol 2000; 53: 323–30

    Article  PubMed  CAS  Google Scholar 

  107. Hunter DJ, Hankinson SE, Laden F, et al. Plasma organochlorine levels and the risk of breast cancer. N Engl J Med 1997; 30: 1253–8

    Article  Google Scholar 

  108. Krieger N, Wollf MS, Hiatt RA, et al. Breast cancer and serum organochlorines: a prospective study among white, black and Asian women. J Natl Cancer Inst 1994; 86: 589–99

    Article  PubMed  CAS  Google Scholar 

  109. Laden F, Hankinson SE, Wolff MS, et al. Plasma organochlorine levels and the risk of breast cancer: an extended follow-up in the nurses health study. Int J Cancer 2000; 15: 568–74

    Google Scholar 

  110. Laden F, Collman G, Iwamoto K. 1-Dichloro-2, 2-bis(p-chlorobiphenyl)ethylene and chlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. J Natl Cancer Inst 2001; 93: 768–76

    Article  CAS  Google Scholar 

  111. Laden F, Ishibe N, Hankinson E, et al. Polychlorinated biphenyls cytochrome P450 1 A1 and breast cancer risk in the nurses health study. Cancer Epidemiol Biomarkers Prev 2002; 11: 1560–5

    PubMed  CAS  Google Scholar 

  112. Liljegren G, Hardell I, Lindström G, et al. Case control study on breast cancer and adipose tissue concentrations of congener specific polychlorinated biphenyls, DDE and hexachlorobenzene. Eur J Cancer Prev 1998; 7: 135–40

    PubMed  CAS  Google Scholar 

  113. Millikan R, Devoto EM, Duell AJ, et al. Dichlorodiphenyldichloroethene, polychlorinated biphenyls, and breast cancer among African and white women in North Carolina. Cancer Epidemiol Biomarkers Prev 2000; 9: 1233–40

    PubMed  CAS  Google Scholar 

  114. Moysich KB, Ambrosone CB, Vena JE, et al. Environmental organochlorine exposure and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 1998; 7: 181–8

    PubMed  CAS  Google Scholar 

  115. Moysich KB, Shields PG, Freudenheim JL, et al. Polychlorinated biphenyls, cytochrome P450 1A1 polymorphism, and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 1999; 8: 41–4

    PubMed  CAS  Google Scholar 

  116. Stellman SD, Dejordjevic MV, Britton JA. Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York. Cancer Epidemiol Biomarkers Prev 2000; 9: 1241–9

    PubMed  CAS  Google Scholar 

  117. Unger M, Kiser H, Blichert-Toft M, et al. Organochlorine compounds in human breast fat from deceased with and without breast cancer and in biopsy material from newly diagnosed patients undergoing breast surgery. Environ Res 1984; 34: 24–8

    Article  PubMed  CAS  Google Scholar 

  118. Ward EM, Schulte P, Grajewski B, et al. Serum organochlorine levels and breast cancer: a nested case control study of Norwegian women. Cancer Epidemiol Biomarkers Prev 2000; 9: 1357–67

    PubMed  CAS  Google Scholar 

  119. Wolff MS, Toniolo PG, Lee EW, et al. Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst 1993; 85: 648–52

    Article  PubMed  CAS  Google Scholar 

  120. Wolff MS, Zelenuich-Jacquotte A, Dubin N, et al. Risk of breast cancer and organochlorine exposure. Cancer Epidemiol Biomarkers Prev 2000; 9: 271–7

    PubMed  CAS  Google Scholar 

  121. Zheng T, Holford TR, Mayne ST, et al. Risk of female breast cancer associated with serum polychlorinated biphenyls and 1,1-dichloro-2, 2’-bis(pchlorophenyl)ethylene. Cancer Epidemiol Biomarkers Prev 2000; 9: 167–74

    PubMed  CAS  Google Scholar 

  122. Zheng T, Holford TR, Tessari J, et al. Breast cancer risk associated with congeners of polychlorinated biphenyls. Am J Epidemiol 2000; 52: 50–8

    Article  Google Scholar 

  123. Dewailly E, Dodin S, Verreault R, et al. High organochlorine body burdens in women with estrogen receptor-positive breast cancer. J Natl Cancer Inst 1994; 86: 232–4

    Article  PubMed  CAS  Google Scholar 

  124. Porta M, Malars N, Jariod M, et al. Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer PANKRAS II Study Group. Lancet 1999; 354: 2125–9

    Article  PubMed  CAS  Google Scholar 

  125. Hoppin JA, Tolbert PE, Holly EA, et al. Pancreatic cancer and serum organochlorine levels. Cancer Epidemiol Biomarkers Prev 2000; 9: 199–205

    PubMed  CAS  Google Scholar 

  126. Sturgeon SR, Brock JW, Potischman N, et al. Serum concentrations of organochlorine compounds and endometrial cancer risk (United States). Cancer Causes Control 1998; 9: 417–24

    Article  PubMed  CAS  Google Scholar 

  127. Weiderpass E, Adami HO, Barton JA, et al. Organochlorines and endometrial cancer risk. Cancer Epidemiol Biomarker Prev 2000; 9: 487–93

    CAS  Google Scholar 

  128. Hardell L, Bavel BM, Lindström G, et al. Higher concentrations of specific polychlorinated biphenyl congeners in adipose tissue from non-Hodgkin’s lymphoma patients compared with controls without a malignant disease. Int J Oncol 1996; 9: 603–8

    PubMed  CAS  Google Scholar 

  129. Rothman N, Cantor KP, Blair A, et al. A nested case control study of non-Hodgkin’s lymphoma and serum organochlorine residues. Lancet 1997; 350: 240–4

    Article  PubMed  CAS  Google Scholar 

  130. Longnecker MP, Wollf MS, Gladen BC, et al. Comparison of polychlorinated biphenyl levels across studies of human development. Environ Health Perspect 2003; 111: 65–70

    Article  PubMed  CAS  Google Scholar 

  131. Taffel SM. Trends in low birth weight: United States, 1975–1985. Hyattsville (MD): US Department of Health and Human Services, Public Health Service, CDC, NCHS; 1989. Vital and health statistics: series 21, no. 48

    Google Scholar 

  132. Taylor PR, Lawrence CE, Hwang HL, et al. Polychlorinated biphenyls: Influence on birth weight and gestation. Am J Public Health 1984; 74: 1153–4

    Article  PubMed  CAS  Google Scholar 

  133. Taylor PR, Stelma JM, Lawrence CE. The relation of polychlorinated biphenyls to birth weight and gestational age in the offspring of occupationally exposed mothers. Am J Epidemiol 1989; 129: 395–406

    PubMed  CAS  Google Scholar 

  134. Fein GG, Jacobson JI, Jacobson SW, et al. Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J Pediatr 1984; 105: 315–20

    Article  PubMed  CAS  Google Scholar 

  135. Rylander L, Strömberg U, Hagmar L. Decreased birth-weight among infants born to women with a high dietary intake of fish contaminated with persistent organochlorine compounds. Scand J Work Environ Health 1995; 21: 368–75

    Article  PubMed  CAS  Google Scholar 

  136. Rylander L, Strömberg U, Dyremark E, et al. Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to low birth weight. Am J Epidemiol 1998; 147: 493–502

    Article  PubMed  CAS  Google Scholar 

  137. Vartainen T, Jaakcola JJ, Saarikosky S, et al. Birth weight and sex of children and the correlation to the body burden of PCDDs/PCDFs and PCBs of the mother. Environ Health Perspect 1998; 106: 61–6

    Article  Google Scholar 

  138. Ribas-Fitó N, Sala M, Cardo E, et al. Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures at birth. Pediatr Res 2002; 52: 163–7

    PubMed  Google Scholar 

  139. Jacobs DS, DeMott WR, Grady WR, et al. Laboratory test handbook. Hudson (OH): Lexi-Comp Inc., 1996

    Google Scholar 

  140. Fisher DA, Klein AH. Thyroid development and disorders of thyroid function in the newborn. N Engl J Med 1981; 304: 702–12

    Article  PubMed  CAS  Google Scholar 

  141. Hahn HR, Spickerman AM, Otto WR, et al. Thyroid function test in neonates fed human milk. Am J Dis Child 1983; 137: 220–2

    PubMed  CAS  Google Scholar 

  142. Koopman-Esseboom C, Morse DC, Weisglas-Kuperus N, et al. Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res 1994; 36: 468–73

    Article  PubMed  CAS  Google Scholar 

  143. Longnecker MP, Gladen BC, Patterson DG, et al. Polychlorinated biphenyl (PCB) exposure in relation to thyroid hormone levels in neonates. Epidemiology 2000; 11: 249–54

    Article  PubMed  CAS  Google Scholar 

  144. Rogan WJ, Gladen BC, McKinney JD, et al. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethane (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health 1986; 76: 172–7

    Article  PubMed  CAS  Google Scholar 

  145. Ribas-Fitó N, Sala M, Cardo E. Organochlorine compounds and concentrations of thyroid stimulating hormone in newborns. Occup Environ Med 2003; 60: 301–3

    Article  PubMed  Google Scholar 

  146. Osius N, Karmaus W, Kruse H, et al. Exposure to polychlorinated biphenyls and levels of thyroid hormones in children. Environ Health Perspect 1999; 107: 843–9

    Article  PubMed  CAS  Google Scholar 

  147. Weisglas-Kuperus N, Sas TCJ, Koopman-Esseboom C, et al. Immunological effects of background prenatal and postnatal exposure to dioxins and polychlorinated biphenyls in Dutch children. Pediatr Res 1995; 38: 404–10

    Article  PubMed  CAS  Google Scholar 

  148. Dewailly E, Bruneau S, Laliberté C, et al. Breast milk contamination by PCBs and PCDDs/PCDFs in Arctic: preliminary results on the immune status of Inuit infants. Organohalogen Compounds 1993; 13: 403–6

    Google Scholar 

  149. Dewailly E, Ayotte P, Bruneau S, et al. Susceptibility to infections and immune status in Inuit infants exposed to organochlorines. Environ Health Perspect 2000; 108: 205–11

    Article  PubMed  CAS  Google Scholar 

  150. Weisglas-Kuperus N, Patandin S, Berbers GAM, et al. Immunological effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect 2000; 108: 1203–7

    Article  PubMed  CAS  Google Scholar 

  151. Karmaus W, Kuehr J, Kruse H. Infections and atopic disorders in childhood and organochlorine exposure. Arch Environ Health 2001; 56: 485–92

    Article  PubMed  CAS  Google Scholar 

  152. Jacobson SW, Jacobson JL, Fein GG. Environmental toxins and infant development. In: Fitzgerald HE, Lester BM, Yogman MW, editors. Theory and research in behavioral pediatrics. New York: Plenum Press, 1986: 3, 96–146

    Google Scholar 

  153. Gladen BC, Rogan WJ, Hardy P, et al. Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. J Pediatr 1988; 113: 991–5

    Article  PubMed  CAS  Google Scholar 

  154. Gladen BC, Rogan WJ. Effects of prenatal polychlorinated biphenyls and dichlorodiphenyl dichloroethene on later development. J Pediatr 1991; 119: 58–63

    Article  PubMed  CAS  Google Scholar 

  155. Jacobson JL, Jacobson SW, Humphrey HEB. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J Pediatr 1990; 116: 38–45

    Article  PubMed  CAS  Google Scholar 

  156. Koopman-Esseboom C, Weisglas-Kuperus N, Van der Paauw CG, et al. Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants psychomotor and mental development. J Pediatr 1996; 97: 700–6

    CAS  Google Scholar 

  157. Lanting CI, Pantadin S, Fidler V, et al. Neurological condition in 42 months old children in relation to pre-and postnatal exposure to polychlorinated biphenyls and dioxins. Early Hum Dev 1998; 50: 283–92

    Article  PubMed  CAS  Google Scholar 

  158. Winneke G, Bucholski A, Heinznow B, et al. Developmental neurotoxicity of polychlorinated biphenyls (PCBs): cognitive and psychomotor functions in 7 month-old children. Toxicol Lett 1998; 102–103: 423–8

    Article  PubMed  Google Scholar 

  159. Daniels JL, Longnecker MP, Klebanoff MA, et al. Prenatal exposure to low level polychlorinated biphenyls in relation to mental and motor development at 8 months. Am J Epidemiol 2003; 157: 485–92

    Article  PubMed  Google Scholar 

  160. Grandjean P, Weihe P, White R, et al. Cognitive deficit in 7 year old children with prenatal exposure to methyl mercury. Neurotoxicol Teratol 1997; 19: 417–28

    Article  PubMed  CAS  Google Scholar 

  161. Grandjean P, Weihe P, Burse V, et al. Neurobehavioral deficits associated with PCB in 7 year old children prenatally exposed to seafood toxicants. Neurotoxicol Teratol 2001; 23: 305–17

    Article  PubMed  CAS  Google Scholar 

  162. Stewart PW, Reihman J, Lonky El, et al. Cognitive development in preschool children prenatally exposed to PCBs and MeHg. Neurotoxicol Teratol 2003; 25: 11–22

    Article  PubMed  CAS  Google Scholar 

  163. Darvill T, Lonky E, Reihman J, et al. Prenatal exposure to PCBs and infant performance on the Fagan Test of infant intelligence. Neurotoxicology 2000; 21: 1029–38

    PubMed  CAS  Google Scholar 

  164. Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med 1996; 338: 783–9

    Article  Google Scholar 

  165. Jacobson JL, Jacobson SW. Association of prenatal exposure to an environmental contaminant with intellectual function in childhood. Clin Toxicol 2002; 40: 467–75

    Article  CAS  Google Scholar 

  166. Jacobson JL, Jacobson SW. Breast-feeding and gender as moderators of teratogenic effects on cognitive development. Neurotoxicol Teratol 2002; 24: 349–58

    Article  PubMed  CAS  Google Scholar 

  167. Mortensen EL, Fleischer Michealsen K, Sanders SA, et al. The association between duration of breast feeding and adult intelligence. JAMA 2002; 287: 2365–71

    Article  PubMed  Google Scholar 

  168. Walkowiak J, Wiener J-A, Fastabend A, et al. Environmental exposure to polychlorinated biphenyls and quality of the home environment: effects on psychodevelopment in early childhood. Lancet 2001; 358: 1602–7

    Article  PubMed  CAS  Google Scholar 

  169. Vreugdenhil HJI, Lanting CI, Mulder PGH, et al. Effects of prenatal PCB and dioxin background exposure on cognitive and motor abilities in Dutch children at school age. J Pediatr 2002; 140: 48–56

    Article  PubMed  CAS  Google Scholar 

  170. Schantz SL, Gasior DM, Polverejan E, et al. Impairments of memory and learning in older adults exposed to polychlorinated biphenyls via consumption of Great Lakes fish. Environ Health Perspect 2001; 109: 605–11

    Article  PubMed  CAS  Google Scholar 

  171. Kuratsune M. Yusho with reference to Yucheng. In: Kimbrough RD, Jensen AA, editors. Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products. Amsterdam: Elsevier North-Holland Biomedical Press, 1989: 381–400

    Chapter  Google Scholar 

  172. Guo YL, Ryan JJ, Lau BPY, et al. Blood serum levels of PCBs and PCDFs in Yucheng women 14 years after exposure to a toxic rice oil. Arch Environ Contam Toxicol 1997; 33: 104–8

    Article  PubMed  CAS  Google Scholar 

  173. Kimbrough RD. Selected other effects and TEFs. Teratog Carcinog Mutagen 1997/98; 17: 265–73

    Article  PubMed  CAS  Google Scholar 

  174. Guo YL, Yu ML, Ryan JJ. Different congeners of PCBs, PCDFs, may have contributed to different health outcomes in the Yucheng cohort. Neurotoxicol Teratol 1996; 18: 1–2

    Article  Google Scholar 

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Acknowledgements

No sources of funding were used to assist in the preparation of this manuscript. The authors have no conflicts of interest that are directly relevant to the content of this manuscript. In the past, the authors have received funding for mortality studies from the General Electric Company.

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    Renate D. Kimbrough & Constantine A. Krouskas

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Kimbrough, R.D., Krouskas, C.A. Human Exposure to Polychlorinated Biphenyls and Health Effects. Toxicol Rev 22, 217–233 (2003). https://doi.org/10.2165/00139709-200322040-00004

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