Skip to main content
SpringerLink
Log in

Cardiovascular Adverse Reactions to Sumatriptan

Cause for Concern?

  • Leading Article
  • Published:
CNS Drugs Aims and scope Submit manuscript

Summary

The serotonin (5-hydroxytryptamine; 5-HT) 5-HT1-receptor agonist sumatriptan is a relatively new antimigraine drug. Some clinical trials and postmarketing surveillance studies of sumatriptan have demonstrated the occurrence of angina pectoris, cardiac arrhythmias and myocardial infarction that can be attributed to the use of the drug.

At present the mechanisms of these adverse effects have not be determined. However, a possible relationship between migraine per se and cardiovascular disease, and an association between serotonin and cardiovascular disease, do exist. There are data to suggest that sumatriptan causes constriction of coronary arteries. In contrast, some investigators believe that the chest pains experienced by some patients who take sumatriptan are not of cardiac origin, but are due to oesophageal contractions. Whatever the cause, it can be concluded that, although severe cardiovascular adverse reactions to sumatriptan may be rare, every case of chest pain after administration of sumatriptan requires careful evaluation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jick H. Drugs — remarkably nontoxic [letter]. N Engl J Med 1974; 291: 824–8

    Article  PubMed  CAS  Google Scholar 

  2. Lin SH, Lin MS. A survey on drug-related hospitalization in a community teaching hospital. Int J Clin Pharm Ther Toxic 1993; 31: 66–9

    CAS  Google Scholar 

  3. Van der Klauw MM, Stricker BHC, Herings RMC, et al. A population based case-cohort study of drug-induced anaphylaxis. Br J Clin Pharmacol 1993; 35: 400–8

    Article  PubMed  Google Scholar 

  4. Anonymous. Glafenine withdrawal recommended. Scrip 1992; 1685: 23

  5. Sumatriptan, serotonin, migraine, and money. Lancet 1992; 339: 151–2

  6. Pearce JMS. Sumatriptan in migraine: may be better than aspirin and metoclopramide. BMJ 1991; 303: 1491

    Article  PubMed  CAS  Google Scholar 

  7. Overmyer RH, Frohlich ED. Sumatriptan, an effective new treatment for migraine, will become available soon. Mod Med 1991; 59: 105–7

    Google Scholar 

  8. Nightingale SL. Sumatriptan approved for migraine headache pain. JAMA 1993; 269: 1776

    Article  PubMed  CAS  Google Scholar 

  9. The Subcutaneous Sumatriptan International Study Group. Treatment of migraine attacks with sumatriptan. N Engl J Med 1991; 325: 316–21

    Google Scholar 

  10. Jack DB. The future of migraine treatment beyond sumatriptan. Inpharma 1994 Oct 1: 9–10

    Google Scholar 

  11. Anonymous. Glaxo Imitrex drug-associated warning subject of dear doctor letter; warning added after patient death in February from migraine drug. FDC Reports-Pink Sheet, 29 Aug 1994; 9

  12. Rasmussen BK, Jensen R, Schroll M, et al. Epidemiology of headache in a general population — a prevalence study. J Clin Epidemiol 1991; 44: 1147–57

    Article  PubMed  CAS  Google Scholar 

  13. Van de Lisdonk E. Perceived and presented morbidity in general practice. Scand J Prim Health Care 1989; 7: 73–8

    Article  PubMed  Google Scholar 

  14. Merikangas KR, Risch NJ, Merikangas JR, et al. Migraine and depression: association and familial transmission. J Psychiatr Res 1988; 22: 119–29

    Article  PubMed  CAS  Google Scholar 

  15. Martignom E, Sances C, Nappi G. Review: significance of hormonal changes in migraine and cluster headache. Gynecol Endocrinol 1987; 1: 295–319

    Article  Google Scholar 

  16. Edelson RN. Menstrual migraine and other hormonal aspects of migraine. Headache 1985; 25: 376–9

    Article  PubMed  CAS  Google Scholar 

  17. Thomas WA, Post WE. Paroxysmal tachycardia in migraine. JAMA 1925; 84: 569–70

    Article  Google Scholar 

  18. Perera GA. Paroxysmal arrhythmias and migraine [letter]. JAMA 1971; 215: 488

    Article  PubMed  CAS  Google Scholar 

  19. Johansson BW. Migraine and the heart. Acta Med Scand 1983; 213: 241–3

    Article  PubMed  CAS  Google Scholar 

  20. Bazak I, Margulis T, Shnaider H, et al. Opthalmoplegic migraine and recurrent sinus arrest. J Neurol Neurosurg Psychiatry 1991; 54: 935–40

    Article  PubMed  CAS  Google Scholar 

  21. Baborier D, Blanc PL, Berthou JD. Association migraine et troubles du rythme cardiaque. J Med Strasbourg 1985; 16: 589

    Google Scholar 

  22. Leon-Sotomayor LA. Cardiac migraine - report of twelve cases. Angiology 1974; 25: 161–71

    Article  PubMed  CAS  Google Scholar 

  23. Briggs JF, Bellomo J. Precordial migraine. Dis Chest 1952; 21: 635–40

    Article  PubMed  CAS  Google Scholar 

  24. Myhrman G. Migrän och paroxysmal tachykardi. Nord Med 1947; 35: 1577–8

    Google Scholar 

  25. Lüthi R, Münch U, Kistler HJ. Vasospastisches Syndrom bei junger Frau mit Migräne, Raynaud-Syndrom, Hirninfarkt und Herzinfarkt. Schweiz Med Wochenschr 1984; 114: 1465–9

    PubMed  Google Scholar 

  26. Freeman Z. Extracranial causes of headache. Med J Aust 1958; 45: 634–7

    PubMed  CAS  Google Scholar 

  27. Caskey W, Spierings E. Headache and heartache. Headache 1978; 18: 240–3

    Article  PubMed  CAS  Google Scholar 

  28. Blacky R, Rittelmeyer J, Wallace M. Headache angina. Am J Cardiol 1987; 60: 730

    Article  PubMed  CAS  Google Scholar 

  29. Lefkowitz D, Biller J. Bregmatic headache as a manifestation of myocardial ischemia. Arch Neurol 1982; 39: 130

    Article  PubMed  CAS  Google Scholar 

  30. Takayanagi K, Fujito T, Morooka S, et al. Headache angina with fatal outcome. Jpn Heart J 1990; 31: 305–7

    Article  Google Scholar 

  31. Bowen J, Oppenheim G. Headache as a presentation of angina: reproduction of symptoms during angioplasty. Headache 1993; 33: 238–9

    Article  PubMed  CAS  Google Scholar 

  32. Zahavi I, Chagnac A, Hering R, et al. Prevalence of Raynaud’s phenomenon in patients with migraine. Arch Intern Med 1984; 144: 742–4

    Article  PubMed  CAS  Google Scholar 

  33. Miller D, Waters DD, Warnica W, et al. Is variant angina the coronary manifestation of a generalized vasospastic disorder? New Engl J Med 1981; 304: 763–6

    Article  PubMed  CAS  Google Scholar 

  34. Leppert J, Åberg H, Ringqvist I, et al. Raynaud’s phenomenon in a female population: prevalence and association with other conditions. Angiology 1987; 38: 871–7

    Article  PubMed  CAS  Google Scholar 

  35. O’Keeffe ST, Tsapatsaris NP, Beetham WP. Increased prevalence of migraine in patients with primary Raynaud disease. Ann Intern Med 1992; 116: 985–9

    PubMed  Google Scholar 

  36. Pliml W, Kommissari I, Pfaffenrath V, et al. Lack of association of migraine with coronary vasospasm. J Intern Med 1991; 230: 455–8

    Article  PubMed  CAS  Google Scholar 

  37. Sicuteri F, Testi A, Anselmi B. Biochemical investigations in headache: increase in the hydroxyindoleacetic acid excretion during migraine attacks. Int Arch Allergy 1961; 19: 55–8

    Article  CAS  Google Scholar 

  38. Griffith SG, Lincoln J, Burnstock G. Serotonin as a neurotransmitter in cerebral arteries. Brain Res 1982; 247: 388–92

    Article  PubMed  CAS  Google Scholar 

  39. Hillis LD, Large RA. Serotonin and acute ischemic heart disease [editorial]. N Engl J Med 1991; 324: 688–90

    Article  PubMed  CAS  Google Scholar 

  40. Thompson JH. Serotonin (5-hydroxytryptamine) and the alimentary system. In: Essman WB, editor. Serotonin in health and disease. New York: Spectrum, 1977; 4: 201–39

    CAS  Google Scholar 

  41. Allen GS, Gross CJ, French LA, et al. Central arterial spasm. Part 5: In vitro contractile activity of vasoactive agents including human CSF on human basilar and anterior cerebral arteries. J Neurosurg 1976; 44: 594–600

    Article  PubMed  CAS  Google Scholar 

  42. Bove AA, Dewey JD. Effects of serotonin and histamine on proximal and distal coronary vasculature in dogs: comparison with alpha-adrenergic stimulation. Am J Cardiol 1983; 52: 1333–9

    Article  PubMed  CAS  Google Scholar 

  43. Lindblad LE, Shepherd JT, Vanhoutte PM. Cooling augments platelet-induced contraction of peripheral arteries of the dog. Proc Soc Exp Biol Med 1984; 176: 119–22

    PubMed  CAS  Google Scholar 

  44. Pietraszek MH, Choudhury NA, Baba S, et al. Serotonin as a factor involved in pathophysiology of thromboangiitis obliterans. Int Angiol 1993; 12: 9–12

    PubMed  CAS  Google Scholar 

  45. Kema IP, de Vries EG, Slooff MJ, et al. Serotonin, catecholamines, histamine, and their metabolites in urine, platelets, and tumor tissue of patients with carcinoid tumors. Clin Chem 1994; 40: 86–95

    PubMed  CAS  Google Scholar 

  46. Senior JB, Fahim I, Sullivan FM, et al. Possible role of 5-hydroxytryptamine in toxaemia of pregnancy. Lancet 1963; 2: 553–4

    Article  PubMed  CAS  Google Scholar 

  47. Freeman Wk, Rorie DK, Tyce GM. Effects of 5-hydroxytryptamine on neuroeffector junction in human pulmonary artery. J Appl Physiol Respir Environ Exercise Physiol 1981; 51: 693–8

    CAS  Google Scholar 

  48. Page IH. Serotonin (5-hydroxytryptamine). Physiol Rev 1954; 34: 563–88

    PubMed  CAS  Google Scholar 

  49. Chandra M, Chandra N. Serotonergic mechanisms in hypertension. Int J Cardiol 1993; 42: 189–96

    Article  PubMed  CAS  Google Scholar 

  50. Peroutka SJ, Havlik S, Oksenberg D. Anti-migraine drug interactions with cloned human 5-hydroxytryptamine1 receptors subtypes. Headache 1993; 33: 347–50

    Article  PubMed  CAS  Google Scholar 

  51. Jansen I, Olesen J, Edvinsson L. 5-Hydroxytryptamine receptor characterization of human cerebral, middle meningeal and temporal arteries: regional differences. Acta Physiol Scand 1993; 147: 141–50

    Article  PubMed  CAS  Google Scholar 

  52. Chu A, Cobb FR. Vasoactive effects of serotonin on proximal coronary arteries in awake dogs. Circ Res 1987; 61:Suppl. II: II81–7

    PubMed  CAS  Google Scholar 

  53. Parsons AA, Stutchbury C, Raval P, et al. Sumatriptan contracts large coronary arteries of beagle dogs through 5-HT1-like receptors. Naunyn Schmiedebergs Arch Pharmacol 1992; 346: 592–6

    Article  PubMed  CAS  Google Scholar 

  54. Ginsburg R, Bristow MR, Davis K, et al. Quantitative pharmacologic response of normal and atherosclerotic isolated human epicardial coronary arteries. Circulation 1984; 69: 430–40

    Article  PubMed  CAS  Google Scholar 

  55. Bax WA, Renzenbrink GJ, van Heuven-Nolsen D, et al. 5-HT receptors mediating contractions of the isolated human coronary artery. Eur J Pharmacol 1993; 239: 203–10

    Article  PubMed  CAS  Google Scholar 

  56. Chester AH, Martin GR, Bodelsson M, et al. 5-Hydroxytryptamine receptor profile in healthy and diseased epicardial coronary arteries. Cardiovasc Res 1990; 24: 932–7

    Article  PubMed  CAS  Google Scholar 

  57. Kaumann AJ, Frenken M, Posival H, et al. Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1Dβ receptors. Circulation 1994; 90: 1141–53

    Article  PubMed  CAS  Google Scholar 

  58. Golino P, Piscione F, Willerson JT, et al. Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. N Engl J Med 1991; 324: 641–8

    Article  PubMed  CAS  Google Scholar 

  59. McFadden EP, Clarke JG, Davies GJ, et al. Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. N Engl J Med 1991; 324: 648–54

    Article  PubMed  CAS  Google Scholar 

  60. Vrints CJM, Bult H, Bosmans J, et al. Paradoxical vasoconstriction as result of acetylcholine and serotonin in diseased human coronary arteries. Eur Heart J 1992; 13: 824–31

    PubMed  CAS  Google Scholar 

  61. Berkenboom G, Unger P, Fang ZY, et al. Comparison of responses to acetylcholine and serotonin on isolated canine and human coronary arteries. Cardiovasc Res 1989; 23: 780–7

    Article  PubMed  CAS  Google Scholar 

  62. Änggård E. Nitric oxide: mediator, murderer, and medicine. Lancet 1994; 343: 1199–206

    Article  PubMed  Google Scholar 

  63. Sikorski BW, James GM, Glance SD, et al. Effect of endothelium on diabetes-induced changes in constrictor responses mediated by 5-hydroxytryptamine in rat aorta. J Cardiovasc Pharmacol 1993; 22: 423–30

    Article  PubMed  CAS  Google Scholar 

  64. Bruning TA, Chang PC, Blauw GJ, et al. Serotonin-induced vasodilation in the human forearm is mediated by the ‘nitric oxide-pathway’: no evidence for involvement of the 5-HT3-receptor. J Cardiovasc Pharmacol 1993; 22: 44–51

    Article  PubMed  CAS  Google Scholar 

  65. Egashira K, Inou T, Hirooka Y, et al. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation 1993; 88: 77–81

    Article  PubMed  CAS  Google Scholar 

  66. Zeiher AM, Drexler H, Saurbier B, et al. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 1993; 92: 652–62

    Article  PubMed  CAS  Google Scholar 

  67. Nitenberg A, Antony I, Foult J-M. Acetylcholine-induced coronary vasoconstriction in young heavy smokers with normal coronary arteriographic findings. Am J Med 1993; 95: 71–7

    Article  PubMed  CAS  Google Scholar 

  68. Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiologic messenger. Ann Intern Med 1994; 120: 227–37

    PubMed  CAS  Google Scholar 

  69. Dechant KL, Clissold SP. Sumatriptan: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs 1992; 43: 776–98

    Article  PubMed  CAS  Google Scholar 

  70. Plosker GL, McTavish D. Sumatriptan: a reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs 1994; 47: 622–51

    Article  PubMed  CAS  Google Scholar 

  71. Pilgrim AJ. Methodology of clinical trials of sumatriptan in migraine and cluster headache. Eur Neurol 1991; 31: 295–9

    Article  PubMed  CAS  Google Scholar 

  72. Welch KMA. Drug therapy of migraine. N Engl J Med 1993; 329: 1476–83

    Article  PubMed  CAS  Google Scholar 

  73. Multinational Oral Sumatriptan and Cafergot Comparative Study Group. A randomized, double-blind comparison of sumatriptan and cafergot in the acute treatment of migraine. Eur Neurol 1991; 31: 314–22

    Google Scholar 

  74. Brown EG, Endersby CA, Smith RN, et al. The safety and tolerability of sumatriptan: an overview. Eur Neurol 1991; 31: 339–44

    Article  PubMed  CAS  Google Scholar 

  75. Visser WH, Ferrari MD, Bayliss EM, et al. for the Subcutaneous Sumatriptan International Study Group. Treatment of migraine attacks with subcutaneous sumatriptan: first placebo-controlled study. Cephalalgia 1992; 12: 308–13

    Article  PubMed  CAS  Google Scholar 

  76. Osborne MJ, Austin RCT, Dawson KJ, et al. Is there a problem with long term use of sumatriptan in acute migraine [letter]? BMJ 1994; 308: 113

    Article  PubMed  CAS  Google Scholar 

  77. Kaube H, May A, Diener HC, et al. Sumatriptan. BMJ 1994; 308: 1573–4

    Article  PubMed  CAS  Google Scholar 

  78. Pini LA, Trenti T. Does chronic use of sumatriptan induce dependence? Headache 1994; 34: 600

    Article  PubMed  CAS  Google Scholar 

  79. Gaist D, Sindrup S, Hallas J, et al. Misuse of sumatriptan [letter]. Lancet 1994; 344: 1090

    Article  PubMed  CAS  Google Scholar 

  80. Luman W, Gray RS. Adverse reactions associated with sumatriptan. Lancet 1993; 341: 1091–2

    Article  PubMed  CAS  Google Scholar 

  81. Tfelt-Hansen P, Ferrari MD, Olesen J. Association between sumatriptan and stroke [letter]. Lancet 1993; 342: 303

    Article  PubMed  CAS  Google Scholar 

  82. Cavazos JE, Caress JB, Chilukuri VR, et al. Sumatriptan-induced stroke in sagittal sinus thrombosis. Lancet 1994; 343: 1105–6

    Article  PubMed  CAS  Google Scholar 

  83. Chiari M, Manzoni GC, Van de Geijn EJ. Ischemic optic neuropathy after sumatriptan in a migraine with aura patient [letter]. Headache 1994; 34: 237–8

    Article  PubMed  CAS  Google Scholar 

  84. Black P, Caldwell J. Skin sensitivity to sumatriptan [letter]. NZ Med J 1994; 107: 20–1

    CAS  Google Scholar 

  85. Inman W, Kubota K. Cardiorespiratory distress after sumatriptan given by injection [letter]. BMJ 1992; 305: 714

    Article  PubMed  CAS  Google Scholar 

  86. Lloyd DK, Pilgrim AJ. The safety of sumatriptan in asthmatic migraineurs. Cephalalgia 1993; 13: 201–4

    Article  PubMed  CAS  Google Scholar 

  87. Stricker BHC. Coronary vasospasm and sumatriptan [letter]. BMJ 1992; 305: 118

    Article  PubMed  CAS  Google Scholar 

  88. Willet F, Curzen N, Adams J, et al. Coronary vasospasm induced by subcutaneous sumatriptan [letter]. BMJ 1992; 304: 1415

    Article  Google Scholar 

  89. Abrahamsen B, Christiansen BD. Angina pectoris after sumatriptan (Imigran). Ugeskr Laeger 1992; 154: 3602–1

    PubMed  CAS  Google Scholar 

  90. Anonymous. Angina pectoris and sumatriptan. Bulletin from SADRAC 1994; 63: 4–5

  91. Lippolis A, Castini D, Cirino D, et al. Coronary vasospasm induced by subcutaneous sumatriptan: a case report. G Ital Cardiol 1994; 24: 883–6

    PubMed  CAS  Google Scholar 

  92. Curtin T, Brooks AP, Roberts JA. Cardiorespiratory distress after sumatriptan given by injection. BMJ 1992; 305: 713–4

    Article  PubMed  CAS  Google Scholar 

  93. Boyd IW, Rohan AP. Sumatriptan-induced chest pain [letter]. Lancet 1994; 344: 1704–5

    Article  PubMed  CAS  Google Scholar 

  94. Ottervanger JP, Paalman HJA, Boxma GL, et al. Transmural myocardial infarction with sumatriptan. Lancet 1993; 341: 861–2

    Article  PubMed  CAS  Google Scholar 

  95. The Oral Sumatriptan and Aspirin Plus Metoclopramide Comparative Study Group. A study to compare oral sumatriptan with oral aspirin plus oral metoclopramide in the acute treatment of migraine. Eur Neurol 1992; 32: 177–84

    Google Scholar 

  96. Cady RK, Wendt JK, Kirchner JR, et al. Treatment of acute migraine with subcutaneous sumatriptan. JAMA 1991; 265: 2831–5

    Article  PubMed  CAS  Google Scholar 

  97. Goadsby PJ, Zagami AS, Donnan GA, et al. Oral sumatriptan in acute migraine. Lancet 1991; 338: 782–3

    Article  PubMed  CAS  Google Scholar 

  98. The Sumatriptan Cluster Headache Study Group. Treatment of acute cluster headache with sumatriptan. N Engl J Med 1991; 325: 322–6

    Google Scholar 

  99. Ottervanger JP, Van Witsen TB, Valkenburg HA, et al. Postmarketing study of cardiovascular adverse reactions associated with sumatriptan. BMJ 1993; 307: 1185

    Article  PubMed  CAS  Google Scholar 

  100. Coulter D. Chest pain and sumatriptan in the IMMP. Prescriber Update 1994: 12–3

    Google Scholar 

  101. Ottervanger JP, Van Witsen TB, Valkenburg HA, et al. Adverse reactions attributed to sumatriptan: a post marketing study in general practice. Eur J Clin Pharmacol 1994; 47: 305–9

    Article  PubMed  CAS  Google Scholar 

  102. Patten JP, for the Oral Sumatriptan Dose-Defining Study Group. Clinical experience with oral sumatriptan: a placebo-controlled, dose-ranging study. J Neurol 1991; 238: 562–5

    Article  Google Scholar 

  103. Parsons AA, Whalley ET, Feniuk W, et al. 5-HT1-like receptors mediate 5-hydroxytryptamine-induced contraction of human isolated basilar artery. Br J Pharmacol 1989; 96: 434–49

    Article  PubMed  CAS  Google Scholar 

  104. Connor HE, Feniuk W, Humphrey PA. 5-hydroxytryptamine contracts human coronary arteries predominantly via 5-HT2-receptor activation. Eur J Pharmacol 1989; 161: 91–4

    Article  PubMed  CAS  Google Scholar 

  105. Schoeffter P, Hoyer D. How selective is GR 43175? Interaction with functional 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol 1989; 340: 135–8

    PubMed  CAS  Google Scholar 

  106. MacIntyre PD, Bhargava B, Hogg, KJ, et al. Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation. Circulation 1993; 87: 401–5

    Article  PubMed  CAS  Google Scholar 

  107. MacIntyre PD, Bhargava B, Hogg, KJ, et al. The effect of i.v. sumatriptan, a selective 5-HT1-receptor agonist on central haemodynamics and the coronary circulation. Br J Clin Pharmacol 1992; 34: 541–6

    PubMed  CAS  Google Scholar 

  108. Buikema H, Grandjean JG. Potentiation of α-adrenoceptor-mediated vasoconstriction by sumatriptan [letter]. Lancet 1993; 342: 1121

    Article  PubMed  CAS  Google Scholar 

  109. MacLean MR, Smith GCS, Templeton AGB. Adverse reactions associated with sumatriptan [letter]. Lancet 1993; 341: 1092

    Article  PubMed  CAS  Google Scholar 

  110. Chester AH, Allen SP, Tadjkarimi S, et al. Interaction between thromboxane A2 and 5-hydroxytryptamine receptor subtypes in human coronary arteries. Circulation 1993; 87: 874–80

    Article  PubMed  CAS  Google Scholar 

  111. Hougton LA, Foster JM, Whorwell PJ, et al. Is chest pain after sumatriptan oesophageal in origin? Lancet 1994; 344: 985–6

    Article  Google Scholar 

  112. Hood S, Brine D, MacIntyre PD, et al. Sumatriptan-induced chest pain [letter]. Lancet 1994; 344: 1500–1

    Article  PubMed  CAS  Google Scholar 

  113. Heberden W. Some account of a disorder of the breast. Med Trans R Coll Physicians 1772; 2: 59–67

    Google Scholar 

  114. Prinzmetal M, Kennamer R, Merliss R, et al. Angina pectoris; 1: a variant form of angina pectoris. Am J Med 1959; 27: 375–88

    Article  PubMed  CAS  Google Scholar 

  115. Matthews MB, Julian DG. Angina pectoris: definition and description. In: Julian DG, editor. Angina pectoris. 2nd ed. New York: Churchill Livingstone, 1985: 2

  116. Vantrappen G, Janssens J. Angina and oesophageal pain: a gastroenterologist’s point of view. Eur Heart J 1986; 7: 828–34

    PubMed  CAS  Google Scholar 

  117. Rapaport E. Angina and oesophageal pain. Eur Heart J 1986; 7: 824–7

    PubMed  CAS  Google Scholar 

  118. Janssens J, Vantrappen G. Angina-like chest pain of oesophageal origin. Baillière’s Clin Gastroenterol 1987; 1: 843–55

    Article  CAS  Google Scholar 

  119. Epstein SE, Gerber LH, Borer JS. Chest wall syndrome. A common cause of unexpected cardiac pain. JAMA 1979; 241: 2793–7

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Netherlands Centre for Monitoring of Adverse Reactions to Drugs, PO Box 5406, 2280 HK, Rijswijk, The Netherlands

    Jan Paul Ottervanger &  Bruno H. Ch. Stricker

  2. Department of Internal Medicine II, Pharmacoepidemiology Unit, University Hospital Dijkzigt, Rotterdam, The Netherlands

    Jan Paul Ottervanger &  Bruno H. Ch. Stricker

Authors
  1. Jan Paul Ottervanger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bruno H. Ch. Stricker
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ottervanger, J.P., Stricker, B.H.C. Cardiovascular Adverse Reactions to Sumatriptan. CNS Drugs 3, 90–98 (1995). https://doi.org/10.2165/00023210-199503020-00002

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00023210-199503020-00002

Keywords

Search

Navigation