Skip to main content

Advertisement

Log in

Physical Activity in Human Hypertension

A Mechanisms Approach

  • Research Review
  • Published:
Sports Medicine Aims and scope Submit manuscript

Summary

The concept of treating hypertension without medication is seen as an attractive alternative to the problems that can arise with the use of drug therapy. Weight loss, salt restriction, relaxation therapy, and exercise have been the non-pharmacological treatments for hypertension.

The role of long term exercise in lowering resting arterial pressure in hypertension, and its use as a non-drug therapy have been studied. Epidemiological studies of athletic ability, occupation, and leisure-time activities have provided equivocal findings and the effect of training on chronic high blood pressure of hypertensives is still unclear. Further well-controlled studies (with respect to training intensities, weight loss, concurrent hypotensive medication, salt restriction, and hypertensive classification), with an emphasis on elucidating the physiological mechanisms involved, are required so that the contribution of exercise to hypertensive therapy can be determined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Abboud, F.M.: The sympathetic system in hypertension. State of the art review. Hypertension 4 (Suppl. 2): 208–225 (1982).

    PubMed  CAS  Google Scholar 

  • Alexander, J.K.: Obesity and the circulation. Modern Concepts of Cardiovascular Disease 32: 799–803 (1963).

    PubMed  CAS  Google Scholar 

  • Barn, A.J.; Daly, J.W.; Pruett, E.D.R.; Steinmetz, J.R.; Page, H.F.; Birkhead, N.C. and Rodahl, K.: The effects of physical conditioning on older individuals. I. Work capacity, circulatory-respiratory function, and work electrocardiogram. Journal of Gerontology 21: 182–191 (1966).

    Google Scholar 

  • Björntorp, P.: Hypertension and exercise. Hypertension 4 (Suppl. 3): 56–59 (1982).

    Google Scholar 

  • Björntorp, P.; de Jounge, K.; Sjöström, L. and Sullivan, L.: The effect of physical training on insulin production in obesity. Metabolism 19: 631–638 (1970).

    Article  PubMed  Google Scholar 

  • Bonnano, J.A. and Lies, J.E.: Effects of physical training on coronary risk factors. American Journal of Cardiology 33: 760–763 (1974).

    Article  Google Scholar 

  • Boyer, J.L. and Kasch, F.W.: Exercise therapy in hypertensive men. Journal of the American Medical Association 211: 1668–1671 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Buskirk, E.R.: Obesity: A brief overview with emphasis on exercise. Federation Proceedings 33: 1948–1951 (1974).

    PubMed  CAS  Google Scholar 

  • Cassel, J.; Heyden, S.; Bartel, A.G.; Kaplan, B.H.; Tyroler, H.A.; Cornoni, A. and Hames, C.G.: Occupation and physical activity and coronary heart disease. Archives of Internal Medicine 128: 920–928 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Chaix, R.L.; Dimitriu, V.M.; Wagniart, P.R. and Safar, M.E.: A simple exercise test in borderline and sustained essential hypertension. International Journal of Cardiology 1: 371–382 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Choquette, G. and Ferguson, R.J.: Blood pressure reduction in borderline hypertensives following physical training. Canadian Medical Association Journal 108: 699–703 (1973).

    PubMed  CAS  Google Scholar 

  • Ciccone, C.D.; Lakas, C.S. and Zambraski, E.J.: Oxygen consumption in treadmill-exercised Yucatan miniature swine. Medicine and Science in Sports and Exercise 14: 467–470 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Cooper, K.H.; Pollock, M.L.; Martin, R.P.; White, S.R.; Linnerud, A.C. and Jackson, A.: Physical fitness levels and selected risk factors. A cross-sectional study. Journal of the American Medical Association 236: 166–169 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Critz, J.B. and Lipsey, P.: Relationships between physical training and DOCA hypertension in rats (39256). Proceedings of the Society for Experimental Biology and Medicine 151: 552–555 (1976).

    PubMed  CAS  Google Scholar 

  • DePlaen, J.F. and Detry, J.M.: Hemodynamic effects of physical training in established arterial hypertension. Acta Cardiologica 35: 179–188 (1980).

    CAS  Google Scholar 

  • Dittman, P.K.: The effect of a low intensity cardiovascular training program on the resting blood pressure of essential hypertensive males. Unpublished Thesis, The Pennsylvania State University (1984).

    Google Scholar 

  • Doan, A.E.; Peterson, D.R.; Blackmon, J.R. and Bruce, R.A.: Myocardial ischaemia after maximal exercise in healthy men. American Journal of Cardiology 17: 9–19 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Donald, D.E. and Ferguson, D.: Response of heart rate, oxygen consumption, and arterial blood pressure to graded exercise in dogs. Proceedings of the Society for Experimental Biology and Medicine 121: 626–630 (1966).

    PubMed  CAS  Google Scholar 

  • Duncan, J.J.; Hagan, R.D.; Upton, J.; Fair, J.E. and Oglesby, M.E.: The effects of an aerobic exercise program on sympathetic neural activity and blood pressure in mild hypertensive patients. (Abstract). Circulation 68: III–285 (1983).

    Google Scholar 

  • Dustan, H.: Mechanisms of hypertension associated with obesity. Annals of Internal Medicine 98: 860–864 (1983).

    PubMed  CAS  Google Scholar 

  • Dustan, H.P.; Tarazi, R.C. and Mujais, S.: A comparison of hemodynamic and volume characteristics of obese and non-obese hypertensive patients. International Journal of Obesity 5 (Suppl. 1): 19–25 (1981).

    PubMed  Google Scholar 

  • Einhorn, D.; Young, J.B. and Landsberg, L.: Hypotensive effect of fasting: Possible involvement of the SNS and endogenous opiates. Science 217: 727–729 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Evenwel, R. and Struyker-Boudier, H.: Effect of physical training on the development of hypertension in the spontaneously hypertensive rat. Pflugers Archiv 381: 19–24 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Fagerberg, B.; Andersson, O.K.; Isaksson, B. and Björntorp, P.: Blood pressure control during weight reduction in obese hypertensive men. British Medical Journal 288: 11–14 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Fletcher, A.P.: The effect of weight reduction upon the blood pressure of obese hypertensive women. Quarterly Journal of Medicine 23: 331–345 (1954).

    PubMed  CAS  Google Scholar 

  • Folkow, B.: Physiological aspects of primary hypertension. Physiological Reviews 62: 347–504 (1982).

    PubMed  CAS  Google Scholar 

  • Folkow, B.; DiBona, G.; Hjemdahl, P.; Thoren, P. and Wallin, B.G.: Measurements of plasma norepinephrine concentrations in human primary hypertension — a word of caution concerning their applicability for assessing neurogenic contribution. Hypertension 5: 399–403 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Franklin, B.A.; Buskirk, E.R.; Hodgson, J.L.; Gahagan, H.; Kollias, J. and Mendez, J.: Effects of physical conditioning on cardiorespiratory function, body composition, and serum lipids in relatively normal-weight and obese middle-aged women. International Journal of Obesity 3: 97–109 (1979).

    PubMed  CAS  Google Scholar 

  • Fregly, M.J.: Effect of an exercise regimen on development of hypertension in rats. Journal of Applied Physiology — Respiratory, Environmental and Exercise Physiology 56: 381–387 (1984).

    PubMed  CAS  Google Scholar 

  • Freis, E.D.: Sodium deprivation as an approach to hypertension; in Laragh et al. (Eds) Frontiers in Hypertension Research, pp.43–45 (Springer-Verlag, New York 1981).

    Chapter  Google Scholar 

  • Frohlich, E.D.: Hemodynamic factors in the pathogenesis and maintenance of hypertension. Federation Proceedings 41: 2400–2408 (1982).

    PubMed  CAS  Google Scholar 

  • Fujita, T. and Katsuyuki, A.: Hemodynamic and endocrine changes associated with potassium supplementation in sodium-loaded hypertensives. Hypertension 6: 184–192 (1984).

    PubMed  CAS  Google Scholar 

  • Garcia-Palmieri, M.R.; Costas, R. Jr; Cruz-Vidal, M.; Sorlie, P.D.; Tillotson, J. and Havlik, R.J.: Milk consumption, calcium intake, and decreased hypertension in Puerto Rico: Puerto Rico Heart Health Program Study. Hypertension 6: 322–328 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Gleeson, T.T. and Baldwin, K.M.: Cardiovascular response to treadmill exercise in untrained rats. Journal of Applied Physiology 50: 1206–1211 (1981).

    PubMed  CAS  Google Scholar 

  • Ciribben, B.; Pickering, T.G.; Sleighl, P. and Peto, R.: Effect of age and high blood pressure on baroreflex sensitivity in man. Circulation Research 29: 424–431 (1971).

    Article  Google Scholar 

  • Guyton, A.C.; Coleman, T.G.; Cowley, A.W.; Scheel, K.W.; Manning, R.D. and Norman, R.A.: Arterial pressure regulation: Overriding dominance of the kidneys in long-term regulation and in hypertension. American Journal of Medicine 52: 584–596 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Hagberg, J.M.; Goldring, D.; Ehsani, A. A. et al.: Effect of exercise training on the blood pressure and hemodynamics of adolescent hypertensives. American Journal of Cardiology 52: 763–768 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Hagberg, J.M.; Goldring, D.; Heath, G.W.; Ehsani, A.A.; Hernandez, A. and Holloszy, J.O.: Effect of exercise training on plasma catecholamines and hemodynamics of adolescent hypertensives during rest, submaximal exercise and orthostatic stress. Clinical Physiology (in press).

  • Hanson, J.; Tabakin, B.; Levy, A. and Nedde, W.: Long-term physical training and cardiovascular dynamics in middle-aged men. Circulation 38: 783–799 (1968).

    Article  Google Scholar 

  • Hanson, J.S. and Nedde, W.H.: Preliminary observations on physical training for hypertensive males. Circulation Research 27 (Suppl. I): 49–53 (1970).

    PubMed  CAS  Google Scholar 

  • Hastings, A.B.; White, F.C.; Sanders, M. and Bloor, C.M.: Comparative physiological responses to exercise stress. Journal of Applied Physiology 52: 1077–1083 (1982).

    PubMed  CAS  Google Scholar 

  • Havlik, R.J.; Hubert, H.B.; Fabsitz, R.R. and Feinleib, M.: Weight and hypertension. Annals of Internal Medicine 98: 855–859 (1983).

    PubMed  CAS  Google Scholar 

  • Henquet, J.W.; van Baak, M.; Schols, M. and Rahn, K.H.: Studies on the autonomic nervous system in borderline hypertension. European Journal of Clinical Pharmacology 22: 285–288 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Heyden, S.; Gyroler, H.A.; Schneider, K.A. et al. (on behalf of the HDFP Cooperative Group): Weight changes and changes in blood pressure, serum uric acid, cholesterol, and glucose in the treatment of hypertension. (Abstract). Circulation 68: 11–91 (1983).

    Google Scholar 

  • Hiramatsu, K.; Yamada, T.; Ichikawa, K.; Izumiyama, T. and Nagata, H.: Changes in endocrine activities relative to obesity in patients with essential hypertension. Journal of the American Geriatrics Society 29: 25–30 (1981).

    PubMed  CAS  Google Scholar 

  • Horton, E.S.: The role of exercise in the treatment of hypertension in obesity. International Journal of Obesity 5 (Suppl. 1): 165–171 (1981).

    PubMed  Google Scholar 

  • Hypertension Detection Follow-up Program Cooperative Group: Description of the enumerated and screened population. Hypertension 5: IV-1–IV-23 (1983).

    Google Scholar 

  • Johnson, W.P. and Grover, J.A.: Hemodynamic and metabolic effects of physical training in four patients with essential hypertension. Canadian Medical Association Journal 96: 842–846 (1967).

    PubMed  CAS  Google Scholar 

  • Kannel, W.B.; Gordon, T.; Serlie, P. and McNamara, P.: Physical activity and coronary vulnerability. The Framingham Study. Cardiovascular Digest June 1971: 28–40 (1971).

    Google Scholar 

  • Kaplan, N.M.: Therapy for mild hypertension. Journal of the American Medical Association 249: 365–367 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Karvonen, M.J.; Rautuharju, P.M.; Orma, E.; Punsar, S. and Takkunen, J.: Cardiovascular studies in lumberjacks. Journal of Occupational Medicine 3: 49–53 (1961).

    PubMed  CAS  Google Scholar 

  • Kolanowski, J.: Influence of glucose, insulin, and glucagon on sodium balance in fasting obese subjects. Perspectives in Biology and Medicine 22: 366–376 (1979).

    PubMed  CAS  Google Scholar 

  • Korner, P.I.; West, M.J.; Shaw, J. and Uther, J.B.: Steady-state properties of the baroreceptor-heart rate reflex in essential hypertension in man. Clinical and Experimental Pharmacology and Physiology 1: 65–76 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Krai, J.A.; Charastek, J. and Adamirova, J.: The hypertensive effect of physical activity in hypertensive subjects; in Raab (Ed.) Prevention of Ischemic Heart Disease, pp.359–371 (C.C. Thomas, Springfield 1966).

    Google Scholar 

  • Krotkiewski, M.; Mandroukas, K.; Morgan, L.; William-Olsson, T.; Feurle, G.E.; von Schenck, H.; Björntorp, P.; Sjöstrom, L. and Smith, U.: Effects of physical training on adrenergic sensitivity in obesity. Journal of Applied Physiology — Respiratory, Environmental and Exercise Physiology 55: 1811–1817 (1983).

    PubMed  CAS  Google Scholar 

  • Krotkiewski, M.; Mandroukas, K.; Sjöstrom, L.; Sullivan, L.; Wetterqvist, H. and Björntorp, P.: Effects of long-term physical training on body fat, metabolism, and blood pressure in obesity. Metabolism 28: 650–658 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Kukkonen, K.; Rauramaa, R.; Voutilainen, E. and Lansimies, E.: Physical training of middle-aged men with borderline hypertension. Annals of Clinical Research 14 (Suppl. 34): 139–145 (1982).

    PubMed  Google Scholar 

  • Landsberg, L. and Young, J.B.: Fasting, feeding and regulation of the sympathetic nervous system. New England Journal of Medicine 298: 1295–1301 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Landsberg, L. and Young, J.B.: Diet and the sympathetic nervous system: Relationship to hypertension. International Journal of Obesity 5: 79–91 (1981).

    PubMed  Google Scholar 

  • Laragh, J.H.: Position paper: Hypertension, vasoconstriction, and the causation of cardiovascular injury. The renin-sodium profile as an indicator of risk; in Laragh et al. (Eds) Frontiers in Hypertension Research, pp.383–395 (Springer-Verlag, New York 1981).

    Chapter  Google Scholar 

  • LeBlanc, J.; Boulay, M.; Dulac, S.; Jobin, M.; Labrie, A. and Rousseau-Migneron, S.: Metabolic and cardiovascular responses to norepinephrine in trained and nontraincd human subjects. Journal of Applied Physiology 42: 166–173 (1977).

    PubMed  CAS  Google Scholar 

  • Leibel, B.; Kobrin, I. and Ben-Ishay, D.: Exercise testing in assessment of hypertension. British Medical Journal 285: 1535–1536 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Leon, A.S. and Blackburn, H.: Physical activity and hypertension; in Sleight and Fries (Eds) Hypertension. Cardiology 1, pp. 14–36 (Buttersworth Scientific, London 1982).

    Google Scholar 

  • Lipman, R.L.; Raskin, P.; Love, T.; Triebwasser, J.; Lecocq, E.R. and Schure, J.J.: Glucose intolerance during decreased physical activity in man. Diabetes 21: 102–107 (1972).

    Google Scholar 

  • Mayer, J. and Bullen, B.A.: Nutrition, weight control, and exercise; in Johnson and Buskirk (Eds) Structural and Physiological Aspects of Exercise and Sport, pp.259–275 (Princeton Book Co., Princeton 1980).

    Google Scholar 

  • McCarron, D.A. and Morris, C.: Calcium for mild to moderate hypertension: A randomized, placebo-controlled trial; in Ninth International Congress of Nephrology, p.216A (Los Angeles, California 1984).

    Google Scholar 

  • Miall, W.E. and Oldham, P.D.: Factors influencing arterial blood pressure in the general population. Clinical Science 17: 400–440 (1958).

    Google Scholar 

  • Miller, J.H. and Bogdonoff, M.D.: Antidiurcsis associated with administration of insulin. Journal of Applied Physiology 6: 509–512 (1954).

    PubMed  CAS  Google Scholar 

  • Montoye, H.J.; Metzner, H.L.; Keller, J.B.; Johnson, B.C. and Epstein, F.H.: Habitual physical activity and blood pressure. Medicine and Science in Sports 4: 175–181 (1972).

    PubMed  CAS  Google Scholar 

  • Multiple Risk Factor Intervention Trial Research Group: Risk factor change and mortality results. Journal of the American Medical Association 248: 1465–1477 (1982).

    Article  Google Scholar 

  • Nazar, K.; Chwalbinska-Moneta, J. and Zukowska-Grojec, Z.: Plasma noradrenaline response to sustained handgrip in patients with essential hypertension. European Journal of Applied Physiology 41: 181–185 (1979).

    Article  CAS  Google Scholar 

  • Paffenberger, R.S.; Hale, W.; Brand, R. and Hydge, R.J.: Work-energy level, personal characteristics and fatal heart attack: A birth-cohort effect. American Journal of Epidemiology 105: 200–213 (1977).

    Google Scholar 

  • Paffenberger, R.S.; Thone, M.C. and Wing, A.L.: Chronic disease in former college students VIII. Characteristics in youth disposing to hypertension in later life. American Journal of Epidemiology 88: 25–52 (1968).

    Google Scholar 

  • Pavlik, G. and Frenkl, R.: Sensitivity to catecholamines and histamine in the trained and in the untrained human organism and sensitivity changes during digestion. European Journal of Applied Physiology 34: 199–204 (1975).

    Article  CAS  Google Scholar 

  • Pawelezyk, J.; Kenney, W.L.; Kenney, P.A. and Buskirk, E.R.: Exercise induced modifications in leg compliance and tilt-table response. Medicine and Science in Sport and Exercise (submitted for publication, 1984).

    Google Scholar 

  • Pcttinger, W.A.: Dietary sodium and renal alpha-2 adrenergic receptors in Dahl hypertensive rats. Clinical and Experimental Hypertension 4: 819–828 (1982).

    Article  Google Scholar 

  • Pickering, T.G.: Nonpharmacological methods of treatment of hypertension promising but unproved. Cardiovascular Reviews and Reports 3: 82–88 (1982).

    Google Scholar 

  • Pyorala, K.; Karvonen, M.J.; Taskinen, P.; Takkunen, J.; Kyronseppa, H. and Peltokallio, P.: Cardiovascular studies on former endurance athletes. American Journal of Cardiology 20: 191–205 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Ramsay, L.E.; Ramsay, M.H.; Hettiarachchi, J.; Davies, D.L. and Winchester, J.: Weight reduction in a blood pressure clinic. British Medical Journal 2: 244–245 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Raven, P.B.; Rohm-Young, D. and Blomqvist, C.G.: Physical fitness and cardiovascular response to lower body negative pressure. Journal of Applied Physiology — Respiratory, Environmental and Exercise Physiology 56: 138–144 (1984).

    PubMed  CAS  Google Scholar 

  • Reaven, G.M. and Reaven, E.P.: Prevention of age-related hypertriglyceridemia by caloric restriction and exercise training in the rat. Metabolism 30: 982–986 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Reisen, E.; Abel, R.; Modan, M.; Silverberg, D.S.; Eliahov, H.E. and Moden, B.: Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. New England Journal of Medicine 298: 1–6 (1978).

    Article  Google Scholar 

  • Ressl, J.; Chrastek, J. and Jandova, R.: Hemodynamic effects of physical training in essential hypertension. Cardiologica 32: 121–133 (1977).

    CAS  Google Scholar 

  • Roberts, J.: Hypertension in adults 25–74 years of age. United States. 1971–1975. Vital and Health Statistics: Series II. Data from the National Health Survey, No. 221 (US Department of Health and Human Services, 1981).

    Google Scholar 

  • Roman, O.; Camuzzi, A.L.; Villalon, E. and Klenner, C.: Physical training program in arterial hypertension. Cardiology 62: 127–128 (1977).

    Google Scholar 

  • Roman, O.; Camuzzi, A.L.; Villalon, E. and Klenner, C.: Physical training program in arterial hypertension. A long-term prospective follow-up. Angiology 67: 230–243 (1981).

    CAS  Google Scholar 

  • Rostand, S.G.; Lewis, D.; Watkins, J.B.; Huang, W.C. and Navar, L.G.: Attenuated pressure natriurcsis in hypertensive rats. Kidney International 21: 330–338 (1982).

    Article  Google Scholar 

  • Rudd, J.L. and Day, W.C.: A physical fitness program for patients with hypertension. Journal of the American Geriatrics Society 15: 373–379 (1967).

    PubMed  CAS  Google Scholar 

  • Sallin, B. and Grimby, G.: Physiological analysis of middle-aged and old former athletes. Circulation 38: 1104–1115 (1968).

    Article  Google Scholar 

  • Sannerstedl, R.; Wasir, H.; Henning, R. and Werko, L.: Systemic haemodynamics in mild arterial hypertension before and after physical training. Clinical Science in Molecular Medicine 45: 145s–149s (1973).

    Google Scholar 

  • Seals, D.R. and Hagberg, J.M.: The effect of exercise training on human hypertension: A review. Medicine and Science in Sports and Exercise 16: 207–215 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Shepherd, R.E.; Kuchne, M.L.; Kenno, K.A.; Durstine, J.L.; Balon, T.W. and Rapp, J.P.: Attenuation of blood pressure increases in Dahl salt-sensitive rats by exercise. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 52: 1608–1613 (1982).

    CAS  Google Scholar 

  • Skrabal, F.; Herholz, H.; Neumayr, M.; Hamberger, L.; Ledochowski, M.; Sporer, H.; Hörtwagl, H.; Schwarz, S. and Schönitzer, D.: Salt sensitivity in humans is linked to enhanced sympathetic responsiveness and to enhanced proximal tubular reabsorption. Hypertension 6: 152–158 (1984).

    PubMed  CAS  Google Scholar 

  • Stegemann, J.; Busert, A. and Brock, D.: Influence of fitness on the blood pressure control system in man. Aerospace Medicine 45: 45–48 (1974).

    PubMed  CAS  Google Scholar 

  • Tarazi, R.C.: Pathophysiology of essential hypertension: Role of the autonomic nervous system. American Journal of Medicine 75 (Suppl. 4a): 2–8 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Taylor, H.L.; Blackburn, H.; Brozck, J.; Parlin, R.W. and Puchner, T.: Railroad employees in the United States. Acta Medica Scandinavica 460 (Suppl.): 55–115 (1967).

    Google Scholar 

  • Tipton, C.M.: Exercise, training and hypertension; in Terjung (Ed.) Exercise and Sport Sciences Reviews, vol. 12, pp.245–306 (D.C Heath and Company, Lexington, Mass. 1984).

    Article  PubMed  CAS  Google Scholar 

  • Tipton, C.M.; Matthes, R.D. and Bedford, T.G.: Influence of training on the blood pressure changes during lower body negative pressure in rats. Medicine and Science in Sports and Exercise 14: 81–90 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Tipton. C.M.; Matthes, R.D.; Marcus, K.D.; Rowlett, K.A. and Leininger, J.R.: Influences of exercise intensity, age. and medication on resting systolic blood pressure of SHR popu-lations. Journal of Applied Physiology — Respiratory, Envi-ronmental and Exercise Physiology 55: 1305–1310 (1983).

    CAS  Google Scholar 

  • Tipton, C.M.; Matthcs, R.D.; Rowictt, K.A.; Edwards, J.G. and Oppligcr, R.A.: Exercise training and peripheral vascular re-sponses of SHR groups. (Abstract). Physiologist 22: 125 (1979).

    Google Scholar 

  • Veterans Administration Cooperative Study Group on Anti-hypertensive Agents: Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressure averaging 115 through 129mm Hg. Journal of the American Medical Association 202: 1028–1031 (1967).

    Article  Google Scholar 

  • Veterans Administration Cooperative Study Group on Anti-hypertensive Agents: Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressure averaging 90 through 114mm Hg. Journal of the American Medical Association 213: 1143–1152 (1970).

    Article  Google Scholar 

  • Wilcox, R.G.; Bennett, T.; Brown, A.M. and MacDonald, I.A.: Is exercise good for high blood pressure? British Medical Journal 285: 767–769(1982).

    Article  PubMed  CAS  Google Scholar 

  • Wilmore. J.H.; Royce, J.; Girandola, R.N.; Katch, F.I. and Katch, V.L.: Physiological alterations resulting from a 10-week program of jogging. Medicine and Science in Sports 2: 7–14 (1970).

    PubMed  CAS  Google Scholar 

  • Winder. W.W.; Hagberg. J.M.; Hickson, R.C; Ehsani. A.A. and McLane. J. A.: Time course of sympathoadrenal adaptation to endurance exercise training in man. Journal of Applied Physiology 45: 370–374(1978).

    PubMed  CAS  Google Scholar 

  • Winternilz. S.R.; Katholi. R.E. and Oparil, S.: Role of the renal sympathetic nerves in the development and maintenance of hypertension in the spontaneously hypertensive rat. Journal of Clinical Investigations 66: 971–978 (1980).

    Article  Google Scholar 

  • Yamori. Y.; Nara. Y.: Kihara. M.; Horie, R.R. and Ooshima. A.: Sodium and other dietary factors in experimental and human hypertension: The Japanese experience; in Laragh et al. (Eds) Frontiers in Hypertension Research, pp.46–48 (Springer-Ver-lag. New York 1981).

    Chapter  Google Scholar 

  • Young. J.B. and Landsberg. L: Diet-induced changes in sympathetic nervous system activity: Possible implications for obesity and hypertension. Journal of Chronic Disease 35: 879–886(1982).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kenney, W.L., Zambraskft, E.J. Physical Activity in Human Hypertension. Sports Medicine 1, 459–473 (1984). https://doi.org/10.2165/00007256-198401060-00005

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00007256-198401060-00005

Keywords

Navigation