Abstract
Background
A novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in Wuhan, China, has been rapidly spreading around the world. This study investigates the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Zhejiang Province who did or did not have a history of Wuhan exposure.
Methods
We collected data from medical records of confirmed COVID-19 patients in Zhejiang Province from Jan. 17 to Feb. 7, 2020 and analyzed epidemiological, clinical, and treatment data of those with and without recorded recent exposure in Wuhan.
Results
Patients in the control group were older than those in the exposure group ((48.19±16.13) years vs. (43.47±13.12) years, P<0.001), and more were over 65 years old (15.95% control vs. 5.60% exposure, P<0.001). The rate of clustered onset was also significantly higher in the control group than in the exposure group (31.39% vs. 18.66%, P<0.001). The symptom of a sore throat in patients in the exposure group was significantly higher than that in the control group (17.30% vs. 10.89%, P=0.01); however, headache in the exposure group was significantly lower than that in the control group (6.87% vs. 12.15%, P=0.015). More patients in the exposure group had a significantly lower level of lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) than those in the control group. There was no significant difference in any degree of COVID-19 including mild, severe, and critical between the two groups.
Conclusions
From the perspective of epidemiological and clinical characteristics, there was no significant difference between COVID-19 patients with and without Wuhan exposure history.
中文概要
目的
调查浙江省有武汉暴露史和无武汉暴露史的新型 冠状肺炎患者的流行病学和临床特征。
创新点
探索新型冠状病毒从武汉市向浙江省传播过程中是否会发生流行病学和临床特征的变化。
方法
我们进行了一项回顾性研究。收集了2020 年1 月17 日至2 月7 日浙江省确诊的新型冠状肺炎患者 的流行病学和临床资料, 并比较分析了有武汉暴 露史和无武汉暴露史患者的流行病学和临床特征。
结论
从流行病学和临床特征的角度来看, 有武汉暴露史和无武汉暴露史的新型冠状肺炎患者之间没 有显著差异。
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Acknowledgments
We thank the Health Commission of Zhejiang Province, China for coordinating data collection. We are grateful to all the front-line medical staffs of Zhejiang Province for their bravery and efforts in COVID-19 prevention and control.
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Contributions
Yi-da YANG and Ji-fang SHENG designed the study and reviewed the manuscript prior to submission. Jiang-shan LIAN coordinated the work and took the lead in drafting the manuscript and interpreting. Huan CAI, Shao-rui HAO, and Xi JIN developed the statistical methods. Xiao-li ZHANG, Lin ZHENG, Hong-yu JIA, Jian-hua HU, Shan-yan ZHANG, Guo-dong YU, Jue-qing GU, Chan-yuan YE, Ci-liang JIN, and Ying-feng LU participated in the collection of experimental data. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted. All authors have read and approved the final manuscript and, therefore, have full access to all the data in the study and take responsibility for the integrity and security of the data.
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Jiang-shan LIAN, Huan CAI, Shao-rui HAO, Xi JIN, Xiao-li ZHANG, Lin ZHENG, Hong-yu JIA, Jian-hua HU, Shan-yan ZHANG, Guo-dong YU, Jue-qing GU, Chan-yuan YE, Ci-liang JIN, Ying-feng LU, Ji-fang SHENG, and Yi-da YANG declare that they have no conflict of interest. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this article.
Additional information
Project supported by the National Major Science and Technology Research Projects for the Control and Prevention of Major Infectious Diseases in China (No. 2017ZX10202202) and the National Natural Science Foundation of China (No. 81770574)
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Lian, Js., Cai, H., Hao, Sr. et al. Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure. J. Zhejiang Univ. Sci. B 21, 369–377 (2020). https://doi.org/10.1631/jzus.B2000112
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DOI: https://doi.org/10.1631/jzus.B2000112
Key words
- Coronavirus disease 2019 (COVID-19)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Zhejiang Province
- Wuhan