Persistent hyperinsulinemic hypoglycemia of infancy

Dinesh Yadav; Bhavna Dhingra; Sandeep Kumar; Virendra Kumar; Ashok Kumar Dutta

doi:10.1515/jpem-2012-0055

Published by De Gruyter May 11, 2012

Persistent hyperinsulinemic hypoglycemia of infancy

Dinesh Yadav , Bhavna Dhingra , Sandeep Kumar , Virendra Kumar and Ashok Kumar Dutta

From the journal Journal of Pediatric Endocrinology and Metabolism

https://doi.org/10.1515/jpem-2012-0055

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Abstract

Congenital hyperinsulinism (CHI) is the most frequent cause of severe, persistent hypoglycemia in infancy and childhood. We report a case of CHI with diffuse pancreatic abnormality diagnosed preoperatively using the ⁶⁸Ga octreotide (DOTA NOC) positron emission tomography scan. Genetic analysis revealed homozygous ABCC8 splicing mutation. Subtotal (95%) pancreatectomy was done, and the infant remained euglycemic and was discharged on breast feeds. The patient is continuously followed up and is asymptomatic until 9 months.

Keywords: congenital hyperinsulinism; DOTA NOC; persistent hypoglycemia

Corresponding author: Dinesh Yadav, Department of Pediatrics, Lady Hardinge Medical College, 02, NRB, New Delhi 110001, India Phone: +91 9868493930

Received: 2012-2-22

Accepted: 2012-4-2

Published Online: 2012-05-11

Published in Print: 2012-06-01

Persistent hyperinsulinemic hypoglycemia of infancy

Abstract

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