Abstract
Blood perfusion is the supply of tissue with blood, and oxygen is a key factor in the field of minor and major wound healing. Reduced perfusion of a wound bed or transplant often causes various complications. Reliable methods for an objective evaluation of perfusion status are still lacking, and insufficient perfusion may remain undiscovered, resulting in chronic processes and failing transplants. Hyperspectral imaging (HSI) represents a novel method with increasing importance for clinical practice. Therefore, methods, software and algorithms for a new HSI system are presented which can be used to observe tissue oxygenation and other parameters that are of importance in supervising healing processes. This could offer an improved insight into wound perfusion allowing timely intervention.
Author Statement
Research funding: Authors state no funding involved.
Conflict of interest: The hyperspectral camera described in this publication was developed by Diaspective Vision GmbH. The first, second and third author are employees of this company. In the long-term, Diaspective Vision has proprietary interest in the development of the camera system resulting in a product for routine clinical use. We certify that the clinical investigators and the co-author have no financial interests and financial arrangements with Diaspective Vision and have received no funding for the preparation of this manuscript.
Informed consent: Informed consent has been obtained from all individuals.
Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies, was performed in accordance with the tenets of the Helsinki Declaration, and has been approved by the local institutional review board (A 2017-0066, Ethics Committee at the University Medical Centre Rostock, Germany) including IRB information were obtained. The hyperspectral camera TIVITA® Tissue is a CE certified medical product (Class I).
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