Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter April 11, 2006

Does Helicobacter pylori cause gastric cancer via oxidative stress?

  • Pelayo Correa
From the journal Biological Chemistry

Abstract

Epidemiologic evidence strongly supports a causal role for Helicobacter pylori in gastric carcinogenesis. The infection was recognized as a Class I human carcinogen by the International Agency for Research on Cancer in 1994. The bacterium does not induce carcinogenesis by itself. The present scientific consensus is that the bacterial oncogenic role is mediated by the chronic active inflammation it elicits in the gastric mucosa. Although the ultimate basic mechanism of carcinogenesis is unknown, strongly suggestive evidence points to oxidative stress as having a pivotal role in the process. This review discusses some of the evidence accumulated so far to support such a role. Numerous avenues of research are open and represent an intriguing challenge to the scientific community.

:

References

Arend, A., Loime, L., Roosaar, P., Soom, M., Loivukene, K., Sepp, E., Aunapuu, M., Zilmer, K., Selstam, G., and Zilmer, M. (2005). Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa. Medicina (Kaunas)41, 343–347.Search in Google Scholar

Blot, W.J., Li, J.Y., Taylor, P.R., Guo, W., Dawsey, S., Wang, G.Q., Yang, C.S., Zheng, S.F., Gail, M., Li, G.Y., et al. (1993). Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. Natl. Cancer Inst.85, 1483–1492.10.1093/jnci/85.18.1483Search in Google Scholar

Bravo, L.E., van Doom, L.J., Realpe, J.L., and Correa, P. (2002). Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma? Am. J. Gastroenterol.97, 2839–2842.10.1111/j.1572-0241.2002.07031.xSearch in Google Scholar

Correa, P. and Miller, M.J. (1998). Carcinogenesis, apoptosis and cell proliferation. Br. Med. Bull.54, 151–162.10.1093/oxfordjournals.bmb.a011665Search in Google Scholar

Correa, P., Haenszel, W., Cuello, C., Tannenbaum, S., and Archer, M. (1975). A model for gastric cancer epidemiology. Lancet2, 58–60.10.1016/S0140-6736(75)90498-5Search in Google Scholar

Correa, P., Haenszel, W., Cuello, C., Zavala, D., Fontham, E., Zarama, G., Tannenbaum, S., Collazos, T., and Ruiz, B. (1990). Gastric precancerous process in a high risk population: cohort follow-up. Cancer Res.50, 4737–4740.Search in Google Scholar

Correa, P., Fontham, E.T., Bravo, J.C., Bravo, L.E., Ruiz, B., Zarama, G., Realpe, J.L., Malcom, G.T., Li, D., Johnson, W.D., and Mera, R. (2000a). Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy. J. Natl. Cancer Inst.92, 1881–1888.Search in Google Scholar

Correa, P., van Doorn, L.J., Bravo, J.C., Ruiz, B., Bravo, L.E., and Realpe, J.L. (2000b). Unsuccessful treatment results in survival of less virulent genotypes of Helicobacter pylori in Colombian patients. Am. J. Gastroenterol.95, 564–566.10.1111/j.1572-0241.2000.t01-1-01813.xSearch in Google Scholar PubMed

Dixon, M.F., Genta, R.M., Yardley, J.H., and Correa, P. (1996). Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am. J. Surg. Pathol.20, 1161–1181.10.1097/00000478-199610000-00001Search in Google Scholar PubMed

Doll, R. and Peto, R. (1978). Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J. Epidemiol. Community Health32, 303–313.10.1136/jech.32.4.303Search in Google Scholar PubMed PubMed Central

Farkas, R., Pronai, L., Tulassay, Z., and Selmeci, L. (2005). Relationship between eradication of Helicobacter pylori and gastric mucosal superoxide dismutase activity. Anticancer Res.25, 4763–4767.Search in Google Scholar

Filipe, M.I., Munoz, N., Matko, I., Kato, I., Pompe-Kirn, V., Jutersek, A., Teuchmann, S., Benz, M., and Prijon, T. (1994). Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int. J. Cancer57, 324–329.10.1002/ijc.2910570306Search in Google Scholar PubMed

Hansson, L.E., Nyren, O., Hsing, A.W., Bergstrom, R., Josefsson, S., Chow, W.H., Fraumeni, J.F. Jr., and Adami, H.O. (1996). The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N. Engl. J. Med.335, 242–249.10.1056/NEJM199607253350404Search in Google Scholar PubMed

Hennekens, C.H., Buring, J.E., Manson, J.E., Stampfer, M., Rosner, B., Cook, N.R., Belanger, C., LaMotte, F., Gaziano, J.M., Ridker, P.M., et al. (1996). Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med.334, 1145–1149.10.1056/NEJM199605023341801Search in Google Scholar PubMed

Herrera, L.A., Benitez-Bribiesca, L., Mohar, A., and Ostrosky-Wegman, P. (2005). Role of infectious diseases in human carcinogenesis. Environ. Mol. Mutagen.45, 284–303.10.1002/em.20122Search in Google Scholar PubMed

Houghton, J., Stoicov, C., Nomura, S., Rogers, A.B., Carlson, J., Li, H., Cai, X., Fox, J.G., Goldenring, J.R., and Wang, T.C. (2004). Gastric cancer originating from bone marrow-derived cells. Science306, 1568–1571.10.1126/science.1099513Search in Google Scholar PubMed

International Agency for Research on Cancer (1994). Schistosomes, Liver Flukes and Helicobacter pylori. Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 61 (Lyon, France: IARC), 177–240.Search in Google Scholar

Kawasaki, K., Nishio, A., Nakamura, H., Uchida, K., Fukui, T., Ohana, M., Yoshizawa, H., Ohashi, S., Tamaki, H., Matsuura, M., et al. (2005). Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1. Lab. Invest.85, 1104–1117.10.1038/labinvest.3700305Search in Google Scholar PubMed

Ley, C., Mohar, A., Guarner, J., Herrera-Goepfert, R., Figueroa, L.S., Halperin, D., Johnstone, I., and Parsonnet, J. (2004). Helicobacter pylori eradication and gastric preneoplastic conditions: a randomized, double-blind, placebo-controlled trial. Cancer Epidemiol. Biomarkers Prev.13, 4–10.10.1158/1055-9965.EPI-03-0124Search in Google Scholar

Mannick, E.E., Bravo, L.E., Zarama, G., Realpe, J.L., Zhang, X.J., Ruiz, B., Fontham, E.T., Mera, R., Miller, M.J., and Correa, P. (1996). Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res.56, 3238–3243.Search in Google Scholar

Matsukura, N., Onda, M., Kato, S., Hasegawa, H., Yoshiyuki, T., et al. (1998). Reversibility of intestinal metaplasia in the stomach after H. pylori eradication. Gastroenterology 114, A220.Search in Google Scholar

Mera, R., Fontham, E.T., Bravo, L.E., Bravo, J.C., Piazuelo, M.B., Camargo, M.C., and Correa, P. (2005). Long term follow up of patients treated for Helicobacter pylori infection. Gut54, 1536–1540.10.1136/gut.2005.072009Search in Google Scholar PubMed PubMed Central

Pignatelli, B., Bancel, B., Plummer, M., Toyokuni, S., Patricot, L.M., and Ohshima, H. (2001). Helicobacter pylori eradication attenuates oxidative stress in human gastric mucosa. Am. J. Gastroenterol.96, 1758–1766.10.1111/j.1572-0241.2001.03869.xSearch in Google Scholar PubMed

Rugge, M., Correa, P., Dixon, M.F., Hattori, T., Leandro, G., Lewin, K., Riddell, R.H., Sipponen, P., and Watanabe, H. (2000). Gastric dysplasia: the Padova international classification. Am. J. Surg. Pathol.24, 167–176.10.1097/00000478-200002000-00001Search in Google Scholar PubMed

Sung, J.J., Lin, S.R., Ching, J.Y., Zhou, L.Y., To, K.F., Wang, R.T., Leung, W.K., Ng, E.K., Lau, J.Y., Lee, Y.T., et al. (2000). Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology119, 7–14.Search in Google Scholar

Uemura, N., Mukai, T., Okamoto, S., Yamaguchi, S., Mashiba, H., Taniyama, K., Sasaki, N., Haruma, K., Sumii, K., and Kajiyama, G. (1997). Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. Cancer Epidemiol. Biomarkers Prev.6, 639–642.Search in Google Scholar

Warren, J.R. and Marshall, B.J. (1983). Unidentified curve bacilli on gastric epithelium in active chronic gastritis. Lancet1, 1273–1275.Search in Google Scholar

Wong, B.C.Y., Lam, S., Wong, W.M., et al. (2002). Eradication of Helicobacter pylori infection significantly slows down the progression of precancerous lesions in high risk population: a 5-year prospective randomized study. Gastroenterology 122, A588.Search in Google Scholar

Wong, B.C., Lam, S.K., Wong, W.M., Chen, J.S., Zheng, T.T., Feng, R.E., Lai, K.C., Hu, W.H., Yuen, S.T., Leung, S.Y., et al., and the China Gastric Cancer Study Group (2004). Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA291, 187–194.10.1001/jama.291.2.187Search in Google Scholar PubMed

Xu, H., Chaturvedi, R., Cheng, Y., Bussiere, F.I., Asim, M., Yao, M.D., Potosky, D., Meltzer, S.J., Rhee, J.G., Kim, S.S., et al. (2004). Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res.64, 8521–8525.10.1158/0008-5472.CAN-04-3511Search in Google Scholar PubMed

Published Online: 2006-04-11
Published in Print: 2006-04-01

©2006 by Walter de Gruyter Berlin New York

Downloaded on 19.5.2024 from https://www.degruyter.com/document/doi/10.1515/BC.2006.048/html
Scroll to top button