Hepatobiliary Transport in Health and Disease

Published by De Gruyter 2012

Hepatobiliary Transport in Health and Disease

Edited by: Dieter Häussinger , Verena Keitel and Ralf Kubitz

https://doi.org/10.1515/9783110279344

Overview
Contents

About this book

One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. Furthermore, new research has shown that bile acids, whose function in digestion is long known, also behave as signal molecules in a variety of organs, including the intestinal and biliary epithelia, sinusoidal endothelial and immune cells. This book provides indepth surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease, the mechanisms of bile salt-induced apoptosis and hepatocyte protection, and the role of transporter mutations as causes and modifiers of liver diseases. The book will be of interest not only for biochemists, structural chemists and biologists, but also for clinicians.

A vital system in liver health and disease
Full color illustrations

Author / Editor information

Dieter Häussinger, Heinrich-Heine Universität, Düsseldorf, Germany.
Ralf Kubitz, Heinrich-Heine Universität, Düsseldorf, Germany.
Verena Keitel, Heinrich-Heine Universität, Düsseldorf, Germany.

Supplementary Materials

Topics

Frontmatter Requires Authentication Unlicensed Licensed Download PDF	i
Preface Requires Authentication Unlicensed Licensed Download PDF	v
List of Contributors Requires Authentication Unlicensed Licensed Download PDF	vii
Contents Requires Authentication Unlicensed Licensed Download PDF	xi
Abbreviations Requires Authentication Unlicensed Licensed Download PDF	xvii
1 Physiology of bile formation: Hepatocellular bile salt transporters Bruno Stieger and Peter J. Meier Requires Authentication Unlicensed Licensed Download PDF	1
2 Structure and function of hepatic ABC transporters Philipp Ellinger, Marianne Kluth, Susanne Przybylla, Sander H. J. Smits and Lutz Schmitt Requires Authentication Unlicensed Licensed Download PDF	23
3 Short- and long-term regulation of hepatobiliary transport Dieter Häussinger and Ralf Kubitz Requires Authentication Unlicensed Licensed Download PDF	49
4 Nuclear bile acid receptor FXR and hepatobiliary transport systems Raffaella Gadaleta and Antonio Moschetta Requires Authentication Unlicensed Licensed Download PDF	71
5 Bile acid signaling in the liver and the biliary tree Dieter Häussinger, Roland Reinehr and Verena Keitel Requires Authentication Unlicensed Licensed Download PDF	85
6 Modulation of innate immunity and inflammation by bile acids and their receptors Dirk Graf and Johannes Bode Requires Authentication Unlicensed Licensed Download PDF	103
7 Bile acids as extrahepatic and interorgan signaling molecules Verena Keitel Requires Authentication Unlicensed Licensed Download PDF	117
8 Disorders of bile duct development Aileen Raizner, Luca Fabris and Mario Strazzabosco Requires Authentication Unlicensed Licensed Download PDF	131
9 Mutations of the bile salt export pump (BSEP) and multidrug-resistance protein 3 (MDR3) Ralf Kubitz and Dieter Häussinger Requires Authentication Unlicensed Licensed Download PDF	151
10 MRP2 (ABCC2) and disorders of bilirubin handling in liver Dietrich Keppler Requires Authentication Unlicensed Licensed Download PDF	171
11 Hepatobiliary transport during pregnancy: Crosstalk between transporters and hormones Roman Müllenbach and Frank Lammert Requires Authentication Unlicensed Licensed Download PDF	183
12 Hepatobiliary transport and gallstone formation Henning Wittenburg Requires Authentication Unlicensed Licensed Download PDF	195
13 Molecular basis of primary biliary cirrhosis Simon Hohenester and Ulrich Beuers Requires Authentication Unlicensed Licensed Download PDF	207
14 The molecular basis of primary sclerosing cholangitis Johannes Roksund Hov, Erik Schrumpf and Tom Hemming Karlsen Requires Authentication Unlicensed Licensed Download PDF	223
15 Drug-induced cholestatic liver injury Christiane Pauli-Magnus and Bruno Stieger Requires Authentication Unlicensed Licensed Download PDF	241
16 Bile acids and receptors: Therapeutic relevance Anna Baghdasaryan, Thierry Claudel and Michael Trauner Requires Authentication Unlicensed Licensed Download PDF	253
17 Analysis of bile acids by tandem mass spectrometry Diran Herebian and Ertan Mayatepek Requires Authentication Unlicensed Licensed Download PDF	277
Index Requires Authentication Unlicensed Licensed Download PDF	289

(Deutsch)

Language: English
Publisher: De Gruyter
Audience: Researchers and advanced students in biochemistry, molecular biology, structural biology, clinical medicine
Pages
- Front matter: 20
- Main content: 292
Illustrations
- Illustrations: 17
- Coloured Illustrations: 21
- Tables: 10
Keywords: Biochemie; Leber; Molekularbiologie; Gastroenterologie

eBook

Published: May 29, 2012
ISBN: 9783110279344

Hardcover

Published: May 18, 2012
ISBN: 9783110278996