Published online Apr 18, 2017.
https://doi.org/10.14776/piv.2017.24.1.23
Clinical Comparison of Influenza A and B Virus Infection in Hospitalized Children
Abstract
Purpose
The objective of this study was to compare the clinical characteristics of influenza A and B infections and analyze the effect of oseltamivir in hospitalized children.
Methods
We investigated children under the age of 15, who were diagnosed with influenza A/H1N1, A/H3N2, or B from January to April 2014. The subjects were admitted to the Changwon Fatima Hospital and diagnosed using a rapid antigen test from nasopharyngeal swabs. The medical records of the patients were retrospectively reviewed.
Results
A total of 302 pediatric patients with influenza were enrolled. Influenza B infection was the most common type (n=187, 61.9%), followed by A/H3N2 (n=100, 33.1%) and A/H1N1 (n=15, 5.0%). Compared to patients diagnosed with influenza A, patients diagnosed with influenza B were older (P=0.005), and the duration of fever was significantly longer (P=0.001). A total of 161 patients (53.3%) had been vaccinated against influenza during the season, before admission. Among the patients infected with A/H3N2 and B, the duration of fever was shorter in oseltamivir recipients compared to oseltamivir non-recipients (P=0.026 and P=0.004, respectively).
Conclusions
There were significant differences between influenza A and B groups in terms of age, demographics, and clinical course. Although the effectiveness of oseltamivir on influenza differs according to the type of influenza, our data provides evidence that oseltamivir is beneficial for both A and B infections.
Fig. 1
The number of children according to the age group.
Fig. 2
The number of children with or without familial contacts in (A) children under 24 months, and in (B) 24 months to 6 years old according to the type of influenza.
Table 1
Clinical and Laboratory Characteristics according to Type of Influenza
Table 2
Presentation of Subjective Symptoms according to Type of Influenza in Children Aged ≥24 Months
References
-
Turner D, Wailoo A, Nicholson K, Cooper N, Sutton A, Abrams K. Systematic review and economic decision modelling for the prevention and treatment of influenza A and B. Health Technol Assess 2003;7:1–170.
-
-
van den Wijngaard CC, van Asten L, Meijer A, van Pelt W, Nagelkerke NJ, Donker GA, et al. Detection of excess influenza severity: associating respiratory hospitalization and mortality data with reports of influenza-like illness by primary care physicians. Am J Public Health 2010;100:2248–2254.
-
-
Youn SE, Chun JH, Lee KS, Rha YH, Choi SH. Clinical characteristics of influenza B virus in children and the efficacy of oseltamivir: data from two university hospitals. Korean J Pediatr Infect Dis 2014;21:199–206.
-
-
Korea Centers for Disease Control and Prevention. Influenza sentinel surveillance report [Internet]. Cheongju: Korea Centers for Disease Control and Prevention; c2012 [cited 2016 Dec 28].Available from: http://www.cdc.go.kr/CDC/info/CdcKrInfo0402.jsp?menuIds=HOME001-
MNU1132- MNU1138- MNU0045&cid=26166.
-
-
Kang TG, Kim MJ, Kim BG, An HS, Yun HJ, Choi EJ, et al. Comparisons of clinical features among influenza A (H1N1) and seasonal influenza A and B during 2009 to 2010 at a single institution. Pediatr Allergy Respir Dis 2011;21:269–276.
-
-
Kim MS, Sung HW, Bae EY, Han SB, Jeong DC, Kang JH. The clinical characteristics of influenza B infection during the 2011-2012 influenza season. Korean J Pediatr Infect Dis 2013;20:89–97.
-