Open Access, Peer-reviewed
pISSN 2384-1079
eISSN 2384-1087
    Korean J Pediatr Infect Dis. 2014 Aug;21(2):114-120. Korean.
    Published online Aug 25, 2014.
    https://doi.org/10.14776/kjpid.2014.21.2.114
    Copyright © 2014 The Korean Society of Pediatric Infectious Diseases
    Original Article

    Active Surveillance of Pertussis in Infants Under 6 Months of Age: A Single Center Experience from 2011 to 2013

    Young Ik Han, M.D., Ji Yeon Choi, M.D., Hyewon Lee, M.S.,* and Teak-jin Lee, M.D.
      • Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
      • *Division of Microbiology, Gyeonggido Public Institute of Health and Environment, Suwon, Korea.
    • Corresponding author (Email: bjloveu@lycos.co.kr )
    Received March 14, 2014; Revised May 13, 2014; Accepted May 13, 2014.

    Abstract

    Purpose

    The objective of this study was to assess and investigate the epidemiology of pertussis in infants under 6 months of age.

    Methods

    A prospective study was conducted between October 1, 2011 and April 30, 2013 in CHA Bundang Medical Center, Seongnam, South Korea. Polymerase chain reaction (PCR) or culture was used to detect Bordetella pertussis in nasopharyngeal aspirates from case patients who were hospitalized for acute lower respiratory tract infection (LRTI). In addition, multiplex real-time PCR assays were also performed to detect 6 etiologic viruses, including adenovirus, human metapeumovirus, influenza virus, parainfluenza virus, respiratory syncytial virus and rhinovirus.

    Results

    Of the 79 enrolled case patients, whose median age was 2 months of age, the most common diagnoses uncovered in this study were acute bronchiolitis (60%) and pneumonia (28%). B. pertussis infection was found in 13 cases (16%), in which 7 (53%) was coinfected with respiratory syncytial virus and 1 (7%) with influenza A virus. Of the 13 patients with B. pertussis infection, 6 (46%) were not vaccinated with the diphtheria, tetanus toxoid, and acellular pertussis vaccine, while 6 (46%) received 1 dose, and 1 (8%) received 2 doses.

    Conclusion

    B. pertussis infection was present in 16% of under 6 month-old infants, who were hospitalized for acute LRTI. Therefore, a nationwide epidemiological surveillance of pertussis, including institutions that cater to infants under 6 months of age is necessary and needed.

    Keywords
    Pertussis; Infants; Vaccination

    Tables

    Table 1
    Characteristics of Infants Aged Under 6 Months Hospitalized for Acute Lower Respiratory Tract Infection

    Table 2
    Organisms Detected in 79 Infants with Acute Lower Respiratory Tract Infection between October 2011 and April 2013

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    MeSH Terms
    Adenoviruses, Human
    Bordetella pertussis
    Bronchiolitis
    Diagnosis
    Diphtheria
    Epidemiology
    Gyeonggi-do
    Humans
    Infant*
    Influenza A virus
    Korea
    Orthomyxoviridae
    Paramyxoviridae Infections
    Pertussis Vaccine
    Pneumonia
    Polymerase Chain Reaction
    Prospective Studies
    Real-Time Polymerase Chain Reaction
    Respiratory Syncytial Viruses
    Respiratory Tract Infections
    Rhinovirus
    Tetanus Toxoid
    Vaccination
    Whooping Cough*
    Metrics
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