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Fatigue

  • Chapter
Parkinson’s Disease and Nonmotor Dysfunction

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

Fatigue is a common complaint in patients with Parkinson’s disease (PD). More than half of all patients with PD rank fatigue among their three worst symptoms. Fatigue has been variously hypothesized to be caused by dysfunction of the striato-thalamo-cortical loop, abnormalities in the hypothalamic-pituitary-adrenal axis, inflammatory processes, and neurotransmitter abnormalities within the central nervous system. However, there is no firm evidence that any of these proposed etiologies explain the fatigue experienced by patients who have PD or other diseases.

Fatigue may be associated with depression, sleep disorders, and medication-induced adverse effects, but it also remains a distinct symptom that can occur independently from these other disorders and problems. Fatigue is a persistent symptom in individual patients, and it is unrelated to disease severity. Fatigue is difficult to define and even more difficult to measure. Several questionnaires are available to measure fatigue, but many of these are disease-specific and do not apply to patients who have PD. Some questionnaires measure general overall fatigue, whereas others measure different aspects of fatigue, including mental, physical, emotional, motivational, and exertional fatigue. Often fatigue is confused with sleepiness, a related but distinct construct. Clearly, fatigue has a significantly negative impact on the quality of life and physical function of patients with PD. Currently, there is no proven effective treatment for this problematic nonmotor symptom of PD. Additional research is needed to provide a better understanding of this complex problem.

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References

  1. Taylor RR, Jason LA, Curie CJ. Prognosis of chronic fatigue in a community-based sample. Psychosom Med 2002;64:319–327.

    PubMed  Google Scholar 

  2. Ridsdale L, Evans A, Jerrett W, et al. Patients with fatigue in general practice: a prospective study. BMJ 1993;307:103–106.

    PubMed  CAS  Google Scholar 

  3. Comi G, Leocani L, Rossi P, Colombo B. Physiopathology and treatment of fatigue in multiple sclerosis. J Neurol 2001;248:174–179.

    Article  PubMed  CAS  Google Scholar 

  4. Tavio M, Milan I, Tirelli U. Cancer-related fatigue. Int J Oncol 2002;21:1093–1099.

    PubMed  Google Scholar 

  5. McCann K, Boore JRP. Fatigue in persons with renal failure who require maintenance hemodialysis. J Adv Nurs 2000;32:1132–1142.

    Article  PubMed  CAS  Google Scholar 

  6. McCrone P, Darbishire L, Ridsdale L, Seed P. The economic cost of chronic fatigue and chronic fatigue in UK primary care. Psychol Med 2000;33:253–261.

    Article  Google Scholar 

  7. French MA. The clinical significance of tiredness. Can Med Assoc J 1960;82:665–671.

    Google Scholar 

  8. Norrelund N, Holnagel H. Fatigue among 40 year olds. Ugeskn Laeger 1979;141:1425–1429.

    CAS  Google Scholar 

  9. Buchwald D, Sullivan JL, Komaroff AL. Frequency of chronic active Epstein Barr Virus infection in a general medical practice. JAMA 1987;25:2303–2307.

    Article  Google Scholar 

  10. Kroenke K, Wood DR, Mangelsdorff E, et al. Chronic fatigue in primary care: prevalence, patient characteristics and outcome. JAMA 1988;260:929–934.

    Article  PubMed  CAS  Google Scholar 

  11. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427–442.

    Article  PubMed  CAS  Google Scholar 

  12. Liang MH, Rogers M, Larson M, et al. The psychosocial impact of systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1984;27:13–19.

    Article  PubMed  CAS  Google Scholar 

  13. Wang B, Gladman DD, Urowitz MB. Fatigue in lupus is not correlated with disease activity. J Rheumatol 1998;25:892–895.

    PubMed  CAS  Google Scholar 

  14. Ford H, Tennant A, Johnson MH. The Leeds MSQOL scale: a disease specific measure of quality of life in multiple sclerosis. J Neurol Neurosurg Psychiatry 1997;62:210.

    Google Scholar 

  15. Ford H, Trigwell P, Johnson M. The nature of fatigue in multiple sclerosis. J Psychosom Res 1998; 45:33–38.

    Article  PubMed  CAS  Google Scholar 

  16. Stein J, Flexner SB, eds. The Random House Thesaurus, College Edition. Random House, New York, 1984.

    Google Scholar 

  17. Gaba DM, Howard SK. Patient safety: fatigue among clinicians and the safety of patients. N Engl J Med 2002;347:1249–1255.

    Article  PubMed  Google Scholar 

  18. Weinstein DF. Duty hours for resident physicians-tough choices for teaching hospitals. N Engl J Med 2002;347: 1275–1278.

    Article  PubMed  Google Scholar 

  19. Seinbrook R. The debate over residents working hours. N Engl J Med 2002;347:1296–1302.

    Article  Google Scholar 

  20. Russel B. Recent work on the principles of mathematics. International Monthly 1901;4:84.

    Google Scholar 

  21. Muscio B. Is a fatigue test possible? Br J Psychol 1921;12:31–46.

    Google Scholar 

  22. Flachenecker P, Kumpfel T, Kallmann B, et al. Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Mult Scler 2002;8:523–526.

    Article  PubMed  CAS  Google Scholar 

  23. Krupp LB, Christodoulou C. Fatigue in multiple sclerosis. Curr Neurol Neurosci Rep 2001;1: 294–298.

    Article  PubMed  CAS  Google Scholar 

  24. Elkins LE, Krupp LB, Scherl W. The measurement of fatigue and contributing neuropsychiatric factors. Semin Clin Neuropsychiatry 2000;5:58–61.

    PubMed  CAS  Google Scholar 

  25. Krupp LB, Pollina DA. Mechanisms and management of fatigue in progressive neurological disorder. Curr Opin Neurol 1996;9:456–460.

    Article  PubMed  CAS  Google Scholar 

  26. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989;46:1121–1123.

    PubMed  CAS  Google Scholar 

  27. Schwartz JE, Jandorf L, Krupp LB. The measurement of fatigue: a new instrument. J Psychosom Res 1993; 37:753–762.

    Article  PubMed  CAS  Google Scholar 

  28. Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC. Fatigue in multiple sclerosis. Arch Neurol 1988; 45:435–437.

    PubMed  CAS  Google Scholar 

  29. Krupp LB, Elkins LE. Fatigue and declines in cognitive functioning in multiple sclerosis. Neurology 2000;55:934–939.

    PubMed  CAS  Google Scholar 

  30. Kleinman L, Zodet MW, Hakim Z, et al. Psychometric evaluation of the fatigue severity scale for use in chronic hepatitis C. Qual Life Res 2000;9:499–508.

    Article  PubMed  CAS  Google Scholar 

  31. Friedman JH, Friedman H. Fatigue in Parkinson’s disease: a nine-year follow-up. Mov Disord 2001; 16:1120–1122.

    Article  PubMed  CAS  Google Scholar 

  32. Friedman J, Friedman H. Fatigue in Parkinson’s disease. Neurology. 1993;43:2016–2018.

    PubMed  CAS  Google Scholar 

  33. Lee KA, Hicks G, Nino-Murcia G. Validity and reliability of a scale to assess fatigue. Psychiatry Res 1991;36:291–298.

    Article  PubMed  CAS  Google Scholar 

  34. Chalder T, Berelowitz G, Pawlikowska T, et al. Development of a fatigue scale. J Psychosom Res 1993; 37:147–153.

    Article  PubMed  CAS  Google Scholar 

  35. Multiple Sclerosis Council for Clinical Practice Guidelines. Fatigue and multiple sclerosis: evidence-based management strategies for fatigue in multiple sclerosis. Multiple Sclerosis Council for Clinical Practice Guidelines, Multiple Sclerosis Society, New York, 1998.

    Google Scholar 

  36. Morriss RK, Wearden AJ, Mullis R. Exploring the validity of the Chalder Fatigue scale in chronic fatigue syndrome. J Psychosom Res 1998;45:411–417.

    Article  PubMed  CAS  Google Scholar 

  37. Taylor RR, Jason LA, Torres A. Fatigue rating scales: an empirical comparison. Psychol Med 2000; 30:849–856.

    Article  PubMed  CAS  Google Scholar 

  38. Zachrisson O, Regland B, Jahreskog M, et al. A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale). J Psychosom Res 2002;52:501–509.

    Article  PubMed  Google Scholar 

  39. Schneider RA. Reliability and validity of the Multidimensional Fatigue Inventory (MFI-20) and the Rhoten Fatigue Scale among rural cancer outpatients. Cancer Nurs 1998;21:370–373.

    Article  PubMed  CAS  Google Scholar 

  40. Schwartz AL. The Schwartz Cancer Fatigue Scale: testing reliability and validity. Oncol Nurs Forum 1998; 25:711–717.

    PubMed  CAS  Google Scholar 

  41. Schwartz AL, Meek PM, Nail LM, et al. Measurement of fatigue. Determining minimally important clinical differences. J Clin Epidemiol 2002;55:239–244.

    Article  PubMed  Google Scholar 

  42. Piper BF, Dibble SL, Dodd MJ, et al. The revised Piper Fatigue Scale: psychometric evaluation in women with breast cancer. Oncol Nurs Forum 1998;25:677–684.

    PubMed  CAS  Google Scholar 

  43. Strohschein FJ, Kelly CG, Clarke AG, et al. Applicability, validity, and reliability of the Piper Fatigue Scale in postpolio patients. Am J Phys Med Rehabil 2003;82:122–129.

    Article  PubMed  Google Scholar 

  44. Lou JS, Reeves A, Benice T, Sexton G. Fatigue and depression are associated with poor quality of life in ALS. Neurology 2003;60:122–123.

    PubMed  Google Scholar 

  45. Gowans SE, DeHueck A, Abbey SE. Measuring exercise-induced mood changes in fibromyalgia: a comparison of several measures. Arthritis Rheum 2002;47:603–609.

    Article  PubMed  CAS  Google Scholar 

  46. Reyes M, Gary HE. Jr, Dobbins JG, et al. Surveillance for chronic fatigue syndrome—four U. S. cities, September 1989 through August 1993. MMWR CDC Surveill Summ 1997;46:1–13.

    PubMed  CAS  Google Scholar 

  47. Peto V, Jenkinson C, Fitzpatrick R, Greenhall R. The development and validation of a short measure of functioning and well being for individuals with Parkinson’s disease. Qual Life Res 1995;4: 241–248.

    Article  PubMed  CAS  Google Scholar 

  48. de Boer AG, Wijker W, Speelman JD, de Haes JC. Quality of life in patients with Parkinson’s disease: development of a questionnaire. J Neurol Neurosurg Psychiatry 1996;61:70–74.

    PubMed  Google Scholar 

  49. Schrag A, Selai C, Jahanshahi M, Quinn NP. The EQ-5D—a generic quality of life measure—is a useful instrument to measure quality of life in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 2000;69:67–73.

    Article  PubMed  CAS  Google Scholar 

  50. Damiano AM, Snyder C, Strausser B, William MK. A review of health related quality of life concepts and measures for Parkinson’s disease. Qual Life Res 1999;8:235–243.

    Article  PubMed  CAS  Google Scholar 

  51. Chaudhuri A, Behan PO. Fatigue and basal ganglia. J Neurol Sci 2000;179:34–42.

    Article  PubMed  CAS  Google Scholar 

  52. Swain MG. Fatigue in chronic disease. Clin Sci (Lond) 2000;99:1–8.

    Article  CAS  Google Scholar 

  53. Lou J-S, Kearns G, Oken B, et al. Exacerbated physical and mental fatigue in Parkinson’s disease. Mov Disord 2001; 16:190–196.

    Article  PubMed  CAS  Google Scholar 

  54. Marek T, Noworol G, Karwowski W. Mental fatigue at work and pain perception. Work Stress 1988;2: 133–137.

    Article  Google Scholar 

  55. LeWitt P.A, Bharucha A, Chitrit I, et al. Perceived exertion and muscle efficiency in Parkinson’s disease: L-Dopa effects. Clin Neuropharmacol 1994;17:454–459.

    Article  PubMed  CAS  Google Scholar 

  56. Ziv I, Avraham M, Michaelov Y, et al. Enhanced fatigue during motor performance in patients with Parkinson’s disease. Neurology 1998;51:1583–1586.

    PubMed  CAS  Google Scholar 

  57. Rowland LP, ed. Merritt’s Neurology, 10th ed. Lippincott, Williams and Wilkins, Philadelphia, PA, 2000.

    Google Scholar 

  58. Paul RH, Cohen RA, Gilchrist JM. Ratings of subjective mental fatigue relate to cognitive performance in patients with myasthenia gravis. J Clin Neurosci 2002;9:243–246.

    Article  PubMed  Google Scholar 

  59. Paul RH, Cohen RA, Goldstein JM, Gilchrist JM. Fatigue and its impact on patients with myasthenia gravis. Muscle Nerve 2000;23:1402–1406.

    Article  PubMed  CAS  Google Scholar 

  60. Merkies IS, Schmitz PI, Samijn JP, et al. Fatigue in immune-mediated polyneuropathies. European Inflammatory Neuropathy Cause and Treatment (INCAT) Group. Neurology 1999;53:1648–1654.

    PubMed  CAS  Google Scholar 

  61. van Hilten JJ, Weggeman M, van der Velde EA, et al. Sleep, excessive daytime sleepiness and fatigue in Parkinson’s disease. J Neural Transm Park Dis Dement Sect 1993;5:235–244.

    Article  PubMed  Google Scholar 

  62. van Hilten JJ, Hoogland G, van der Velde EA, et al. Diurnal effects of motor activity and fatigue in Parkinson’s disease. J Neurol Neurosurg Psychiatry 1993;56:874–877.

    PubMed  Google Scholar 

  63. Garber CE, Friedman JH. Effects of fatigue on physical activity and function in patients with Parkinson’s disease. Neurology 2003;60:1119–1124.

    Article  PubMed  Google Scholar 

  64. Critchley PH, Malcolm GP, Malcolm PN, et al. Fatigue and melatonin in Parkinson’s disease. J Neurol Neurosurg Psychiatry 1991;54:91–92.

    Article  PubMed  CAS  Google Scholar 

  65. Marsden CD, Parkes JC, Quinn N. Fluctuations of disability in Parkinson’s Disease Clinical Aspects. In: Marsden CD, Fain S., eds. Movement Disorders, London: Butterworth’s, 1982;96–119.

    Google Scholar 

  66. Schwab RS, England AC, Peterson C. Akinesia in Parkinson’s disease. Neurology 1959;9: 65–72.

    PubMed  CAS  Google Scholar 

  67. Yessavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1983;17:37–49.

    Article  Google Scholar 

  68. Schenkman M, Wei Zhu C, Cutson T. M, Whetten-Goldstein K. Longitudinal evaluation of economic and physical impact of Parkinson’s disease. Parkinsonism Relat Disord 2001;8:41–50.

    Article  PubMed  CAS  Google Scholar 

  69. Shulman LM, Taback RL, Bean J, Weiner WJ. Comorbidity of the nonmotor symptoms of Parkinson’s disease. Mov Disord 2001;16:507–510.

    Article  PubMed  CAS  Google Scholar 

  70. Abe K, Takanashi M, Yanagihara T. Fatigue in patients with PD. Behav Neurol 2000;12:103–106.

    PubMed  Google Scholar 

  71. Herlofson K, Larsen JP. Measuring fatigue in patients with Parkinson’s disease—the Fatigue Severity Scale. Eur J Neurol 2002;9:595–600.

    Article  PubMed  CAS  Google Scholar 

  72. Smets EM, Garssen B, Bonke B, de Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res 1995;39:315–325.

    Article  PubMed  CAS  Google Scholar 

  73. Tolson D, Fleming V, Schartau E. Coping with menstruation: understanding the needs of women with Parkinson’s disease. J Adv Nurs 2002;40:513–521.

    Article  PubMed  Google Scholar 

  74. Burn DJ. Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson’s disease. Mov Disord 2002;17:445–454.

    Article  PubMed  Google Scholar 

  75. Friedman JH, Fernandez HH. The nonmotor problems of Parkinson’s disease. The Neurologist 2000; 6:8–27.

    CAS  Google Scholar 

  76. Dooneief G, Mirabello E, Bell K, et al. An estimate of the incidence of depression in idiopathic Parkinson’s disease. Arch Neurol 1992;49:305–307.

    PubMed  CAS  Google Scholar 

  77. Tandberg E, Larsen JP, Aarsland D, Cummings JL. The occurrence of depression in Parkinson’s disease. A community-based study. Arch Neurol 1996;53:175–179.

    PubMed  CAS  Google Scholar 

  78. Richard IH. Depression in Parkinson’s disease. Curr Treat Options Neurol 2000;2:263–274.

    Article  PubMed  Google Scholar 

  79. Schrag A, Jahanshahi M, Quinn NP. What contributes to depression in Parkinson’s Disease? Psychol Med 2001;31:65–73.

    Article  PubMed  CAS  Google Scholar 

  80. Cummings JL. Depression and Parkinson’s disease, A review. Am J Psychiatry 1992;149: 443–454.

    PubMed  CAS  Google Scholar 

  81. Gotham AM, Brown RG, Marsden CD. Depression in Parkinson’s disease: a quantitative and qualitative analysis. J Neurol Neurosurg Psychiatry 1986;49:381–389.

    PubMed  CAS  Google Scholar 

  82. Karlsen K, Larsen JP, Trandberg E, Jorgensen K. Fatigue in patients with Parkinson’s disease. Mov Disord 1999;14:237–241.

    Article  PubMed  CAS  Google Scholar 

  83. Vercoulen JH, Swanink CM, Galama JM, et al. The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: development of a model. J Psychosom Res 1998;45:507–517.

    Article  PubMed  CAS  Google Scholar 

  84. Schwartz CE, Coulthard-Morris L, Zeng Q. Psychosocial correlates of fatigue in multiple sclerosis. Arch Phys Med Rehabil 1996;77:165–170.

    Article  PubMed  CAS  Google Scholar 

  85. Mainero C, Faroni J, Gasperini C, et al. Fatigue and magnetic resonance imaging activity in multiple sclerosis. J Neurol 1999;246:454–458.

    Article  PubMed  CAS  Google Scholar 

  86. Giovannoni G, Thompson AJ, Miller DH, Thompson EJ. Fatigue is not associated with raised inflammatory markers in multiple sclerosis. Neurology 2001;57:676–681.

    PubMed  CAS  Google Scholar 

  87. Roelcke U, Kappos L, Lechner-Scott J, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology 1997;48:1566–1571.

    PubMed  CAS  Google Scholar 

  88. Filippi M, Rocca MA, Colombo B, et al. Functional magnetic resonance imaging correlates of fatigue in multiple sclerosis. Neuroimage 2002;15:559–567.

    Article  PubMed  CAS  Google Scholar 

  89. Colombo B, Martinelli-Boneschi F, Rossi P, et al. MRI and motor evoked potential findings in nondisabled multiple sclerosis patients with and without symptoms of fatigue. J Neurol 2000;247:506–509.

    Article  PubMed  CAS  Google Scholar 

  90. Codella M, Rocca MA, Colombo B, et al. Cerebral grey matter pathology and fatigue in patients with multiple sclerosis: a preliminary study. J Neurol Sci 2002;194:71–74.

    Article  PubMed  CAS  Google Scholar 

  91. van der Werf SP, Jongen PJ, Lycklama a Nijeholt GJ, et al. Fatigue in multiple sclerosis: interrelations between fatigue complaints, cerebral MRI abnormalities and neurological disability. J Neurol Sci 1998;160:164–170.

    Article  PubMed  Google Scholar 

  92. McLester JR, Jr. Muscle contraction and fatigue: the role of adenosine 5′-diphospate and inorganic phosphate. Sports Med 1997;23:287–305.

    PubMed  Google Scholar 

  93. Taylor DJ, Krige D, Barnes PR, et al. A 31P magnetic resonance spectroscopy study of mitochondrial function in skeletal muscle of patients with Parkinson’s disease. J Neurol Sci 1994;125:77–81.

    Article  PubMed  CAS  Google Scholar 

  94. Schapira AH. Evidence for mitochondrial dysfunction in Parkinson’s disease-a critical appraisal. Mov Disord 1994;9:125–138.

    Article  PubMed  CAS  Google Scholar 

  95. Reichmann H, Janetzky B. Mitochondrial dysfunction—a pathogenetic factor in Parkinson’s disease. J Neurol 2000;247(Suppl 2):1163–1168.

    Google Scholar 

  96. Hood DA. Invited review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol 2001;90:1137–1157.

    PubMed  CAS  Google Scholar 

  97. Davis JM. Central and peripheral factors in fatigue. J Sports Sci 1995;13(Spec No):S49–S53.

    PubMed  Google Scholar 

  98. Davis JM, Bailey SP. Possible mechanisms of central nervous system fatigue during exercise. Med Sci Sports Exerc 1997;29:45–57.

    PubMed  CAS  Google Scholar 

  99. Ingram DK. Age-related decline in physical activity: generalization to nonhumans. Med Sci Sports Exerc 2000;32:1623–1629.

    Article  PubMed  CAS  Google Scholar 

  100. Radak Z, Sasvari M, Nyakas C, et al. Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain. Neurochem Int 2001;39:33–38.

    Article  PubMed  CAS  Google Scholar 

  101. Weicker H, Struder HK. Influence of exercise on serotonergic neuromodulation in the brain. Amino Acids 2001;20:35–47.

    Article  PubMed  CAS  Google Scholar 

  102. Levi S, Cox M, Lugon M, et al. Increased energy expenditure in Parkinson’s disease. BMJ 1990; 301:1256–1257.

    PubMed  CAS  Google Scholar 

  103. Markus HS, Cox M, Tomkins AM. Raised resting energy expenditure in Parkinson’s disease and its relationship to muscle rigidity. Clin Sci 1992;83:1999–2004.

    Google Scholar 

  104. Pogarell O, Gasser T, van Hilten JJ, et al. Pramipexole in patients with Parkinson’s disease and marked drug resistant tremor: a randomized, double blind, placebo controlled multicenter study. J Neurol Neurosurg. Psychiatry 2002;72:713–720.

    Article  PubMed  CAS  Google Scholar 

  105. Schlesinger I, Ravin PD. Dopamine agonists induce episodes of irresistible daytime sleepiness. Eur Neurol 2003;49:30–33.

    Article  PubMed  CAS  Google Scholar 

  106. Abe K, Takanashi M, Yanagihara T, Sakoda S. Pergolide mesilate may improve fatigue in patients with Parkinson’s disease. Behav Neurol 2001–2002;13:117–121.

    PubMed  Google Scholar 

  107. De Pandis MF, Starace A, Stefanelli F, et al. Modification of respiratory function parameters in patients with severe Parkinson’s disease. Neurol Sci 2002;23(Suppl 2):S69–S70.

    Article  PubMed  Google Scholar 

  108. Sabate M, Rodriguez M, Mendez E, et al. Obstructive and restrictive pulmonary dysfunction increases disability in Parkinson disease. Arch Phys Med Rehabil 1996;77:29–34.

    Article  PubMed  CAS  Google Scholar 

  109. Polatli M, Akyol A, Cildag O, Bayulkem K. Pulmonary function tests in Parkinson’s disease. Eur J Neurol 2001;8:341–345.

    Article  PubMed  CAS  Google Scholar 

  110. Weiner P, Inzelberg R, Davidovich A, et al. Respiratory muscle performance and the perception of dyspnea in Parkinson’s disease. Can J Neurol Sci 2002;29:68–72.

    PubMed  Google Scholar 

  111. Tzelepis GE, McCool FD, Friedman JH, Hoppin FG Jr. Respiratory muscle dysfunction in Parkinson’s disease. Am Rev Respir Dis 1988;138:266–271.

    PubMed  CAS  Google Scholar 

  112. Masoudi O, Davis K, Siram A, et al. Ventilation during submaximal exercise in Parkinson’s disease. American Thoracic Society (abstract), American Thoracic Society, New York, 2000.

    Google Scholar 

  113. Tench C, Bentley D, Vleck V, et al. Aerobic fitness, fatigue, and physical disability in systemic lupus erythematosus. J Rheumatol 2002;29:474–481.

    PubMed  Google Scholar 

  114. Shephard RJ. The scientific basis for exercise prescribing for the very old. J Am Geriatr Soc 1990; 38:62–70.

    PubMed  CAS  Google Scholar 

  115. American College of Sports Medicine. The recommended quantity and quality for exercise for developing and maintaining cardiorespiratory and muscular fitness in healthy adults. Med Sci Sports Exerc 1998;30: 975–991.

    Article  Google Scholar 

  116. American College of Sports Medicine. ACSM Position Stand on Exercise and Physical Activity for Older Adults. Med Sci Sports Exerc 1998;30:992–1008.

    Article  Google Scholar 

  117. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion. Physical Activity and Health: A Report of the Surgeon General. US Department of Health and Human Services, Atlanta, GA, 1996.

    Google Scholar 

  118. Babyak M, Blumenthal JA, Herman S, et al. Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosomatic Med 2000;62:633–638.

    CAS  Google Scholar 

  119. Bergen JL, Toole T, Elliott RG III, et al. Aerobic exercise intervention improves aerobic capacity and movement initiation in Parkinson’s disease patients. NeuroRehabilitation 2002;17:161–168.

    PubMed  Google Scholar 

  120. Baatile J, Langbein WE, Weaver F, et al. Effect of exercise on perceived quality of life of individuals with Parkinson’s disease. J Rehabil Res Dev 2000;37:529–534.

    PubMed  CAS  Google Scholar 

  121. Scandalis TA, Bosak A, Berliner JC, et al. Resistance training and gait function in patients with Parkinson’s disease. Am J Phys Med Rehabil 2001;80:38–43.

    Article  PubMed  CAS  Google Scholar 

  122. de Goede CJ, Keus SH, Kwakkel G, Wagenaar RC. The effects of physical therapy in Parkinson’s disease: a research synthesis. Arch Phys Med Rehabil 2001;82:509–515.

    Article  PubMed  Google Scholar 

  123. Stanley RK, Protas EJ, Jankovic J. Exercise performance in those having Parkinson’s disease and healthy normals. Med Sci Sports Exerc 1999;31:761–766.

    Article  PubMed  CAS  Google Scholar 

  124. Comella CL, Stebbins GT, Brown-Toms N, Goetz CG. Physical therapy and Parkinson’s disease. Neurology 1994;44:376–378.

    PubMed  CAS  Google Scholar 

  125. Formisano R, Pratesi L, Modarelli FT, et al. Rehabilitation and Parkinson’s disease. Scand J Rehab Med 1992;24:157–160.

    CAS  Google Scholar 

  126. Reuter I, Englehardt M, Stecker K, Baas H. Therapeutic value of exercise training in Parkinson’s disease. Med Sci Sports Exerc 1999;31:1544–1549.

    Article  PubMed  CAS  Google Scholar 

  127. Pierce EF, Pate DW. Mood alterations in older adults following acute exercise. Percept Mot Skills 1994;79:191–194.

    PubMed  CAS  Google Scholar 

  128. Annesi JJ. Effects of minimal exercise and cognitive behavior modification on adherence, emotion change, self-image, and physical change in obese women. Percept Mot Skills 2000;91:322–336.

    Article  PubMed  CAS  Google Scholar 

  129. Mostert S, Kesselring J. Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis. Mult Scler 2002;8:161–168.

    Article  PubMed  CAS  Google Scholar 

  130. Gowans SE, de Hueck A, Voss S, et al. Effect of a randomized, controlled trial of exercise on mood and physical function in individuals with fibromyalgia. Arthritis Rheum 2001;45:519–529.

    Article  PubMed  CAS  Google Scholar 

  131. Fulcher KY, White PD. Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome. BMJ 1997;314:1647–1652.

    PubMed  CAS  Google Scholar 

  132. Robb-Nicholson LC, Daltroy L, Eaton H, et al. Effects of aerobic conditioning in lupus fatigue: a pilot study. Br J Rheumatol 1989;28:500–505.

    Article  PubMed  CAS  Google Scholar 

  133. Portenoy RK, Itri LM. Cancer-related fatigue: guidelines for evaluation and management. The Oncologist 1999;4:1–10.

    PubMed  CAS  Google Scholar 

  134. Mock V, Atkinson A, Barsevick A, et al. NCCN practice guidelines for cancer-related fatigue. Oncology (Huntingt) 2000;14:151–161.

    CAS  Google Scholar 

  135. Tavio M, Milan I, Tirelli U. Cancer-related fatigue (review). Int. J Oncol 2002;21:1093–1099.

    PubMed  Google Scholar 

  136. Manzullo EF, Escalante CP. Research into fatigue. Hematol Oncol Clin North Am 2002;16:619–628.

    Article  PubMed  Google Scholar 

  137. Schwartz AL, Mori M, Gao R, et al. Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med Sci Sports Exerc 2001;33:718–723.

    Article  PubMed  CAS  Google Scholar 

  138. Berger AM. Patterns of fatigue and activity and rest during adjuvant breast cancer chemotherapy. Oncol Nurs Forum 1998;25:51–62.

    PubMed  CAS  Google Scholar 

  139. Servaes P, Verhagen CA, Bleijenberg G. Relations between fatigue, neuropsychological functioning, and physical activity after treatment for breast carcinoma: daily self-report and objective behavior. Cancer 2002;95: 2017–2026.

    Article  PubMed  Google Scholar 

  140. Servaes P, Prins J, Verhagen S, Bleijenberg G. Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences. J Psychosom Res 2002;52:453–459.

    Article  PubMed  Google Scholar 

  141. Dimeo F, Rumberger BG, Keul J. Aerobic exercise as therapy for cancer fatigue. Med Sci Sports Exerc 1998;30:475–478.

    PubMed  CAS  Google Scholar 

  142. Schwartz AL. Patterns of exercise and fatigue in physically active cancer survivors. Oncol Nurs Forum 1998;25:485–491.

    PubMed  CAS  Google Scholar 

  143. Oldervoll LM, Kaasa S, Knobel H, Loge JH. Exercise reduces fatigue in chronic fatigued Hodgkins disease survivorsresults from a pilot study. Eur J Cancer 2003;39:57–63.

    Article  PubMed  CAS  Google Scholar 

  144. Mock V, Pickett M, Ropka ME, et al. Fatigue and quality of life outcomes of exercise during cancer treatment. Cancer Pract 2000;9:119–127.

    Article  Google Scholar 

  145. Schwartz AL. Fatigue mediates the effects of exercise on quality of life. Qual Life Res 1999;8: 529–538.

    Article  PubMed  CAS  Google Scholar 

  146. Freal JD, Kraft GH, Coryell JK. Symptomatic fatigue in multiple sclerosis. Arch Physical Medical Rehabil 1984;5:135–137.

    Google Scholar 

  147. Berrios GE. Feelings of fatigue and psychopathology: a conceptual history. Comp Psychiatry 1990;31: 140–151.

    Article  CAS  Google Scholar 

  148. Tavio M, Milan I, Tirelli U. Cancer-related fatigue (a review). Int J Oncol 2002;21:1093–1099.

    PubMed  Google Scholar 

  149. Lane R. Chronic fatigue syndrome: is it physical? J Neurol Neurosurg. Psychiatry 2000;69:289.

    Article  PubMed  CAS  Google Scholar 

  150. Shapiro RT, Schneider DM. Fatigue. In: van den Noort S, Holland N, eds. Multiple Sclerosis in Clinical Practice. Demos, New York, 1999, chapter 3.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cardiopulmonary and Exercise Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA

    Carol Ewing Garber PhD

  2. Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI

    Joseph H. Friedman MD

Authors
  1. Carol Ewing Garber PhD
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  2. Joseph H. Friedman MD
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Editor information

Editors and Affiliations

  1. Department of Neurology, University of Tennessee Health Science Center, Memphis, TN

    Ronald F. Pfeiffer MD

  2. Department of Neurology, State University of New York, Downstate Medical Center, Brooklyn, NY

    Ivan Bodis-Wollner MD, DSc

  3. Department of Ophthalmology, State University of New York, Downstate Medical Center, Brooklyn, NY

    Ivan Bodis-Wollner MD, DSc

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© 2005 Humana Press Inc., Totowa, NJ

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Garber, C.E., Friedman, J.H. (2005). Fatigue. In: Pfeiffer, R.F., Bodis-Wollner, I. (eds) Parkinson’s Disease and Nonmotor Dysfunction. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-859-5:281

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  • DOI: https://doi.org/10.1385/1-59259-859-5:281

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-316-9

  • Online ISBN: 978-1-59259-859-5

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