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Short- and Long-Term Outcomes of Patients Requiring Gastrectomy During Cytoreductive Surgery and Intraperitoneal Chemotherapy for Lower-Gastrointestinal Malignancies: A Propensity Score-Matched Analysis

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Objectives

This study was designed to assess the short- and long-term outcomes of gastric resection in cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) for lower gastrointestinal (GI) malignancies.

Methods

Patients with adenocarcinoma and appendiceal mucinous neoplasms were included. Redo and incomplete cytoreductions were excluded. A total of 756 patients were identified. Of these, 65 underwent gastric resection, 11 underwent wedge, 43 distal, and 11 subtotal and total gastrectomy. Preoperative differences were assessed for and addressed with matching. Perioperative outcomes, overall survival (OS), and risk-free survival (RFS) were assessed in two analyses: first all gastric resections were included and the second excluded wedge resections. Subgroup analysis according to diagnosis subtype was conducted.

Results

Demographic analysis revealed that markers of tumor aggression and poor nutrition were prevalent in the gastrectomy group. The matched analysis for gastric resections revealed higher rates of reoperation (38% vs. 22%, p = 0.028). After excluding wedge resections, increased rates of reoperation (40% vs. 22%, 0.019), grade 3/4 morbidity (76% vs. 59%, p = 0.036), and hospital stay (34 vs. 27 days, p = 0.012) were observed. For the unmatched cohort, OS (103 vs. 69 months, p = 0.501) and RFS (17 vs. 18 months, p = 0.181) for patients with CC = 0 were insignificantly different. In comparison for CC > 0, OS (31 vs. 83 months, p < 0.001) and RFS (9 vs. 20 months, p < 0.001) were significantly reduced in gastric resection. For the matched cohort, after excluding wedges, gastrectomy did not significantly decrease OS. However, RFS was decreased (11 vs. 20 months, p = 0.016).

Conclusions

Despite high postoperative morbidity, when complete cytoreduction is achieved, the need for gastric resection is not associated with inferior long-term outcomes.

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Author notes

  1. Bhavneet Singh and Oliver M. Fisher contributed equally as first authors.

Authors and Affiliations

  1. Liver and Peritonectomy Unit, St George Hospital, Sydney, Australia

    Bhavneet Singh MBBS, Oliver M. Fisher MD, PhD, Gurkirat Singh MBBS, Joshua Lansom MBBS, Michael Bock MBBS, Mathew Kozman MBBS, MS, FRACS, Nayef Alzahrani MBBS, SBGS, Winston Liauw MBBS, MMEDSCI, MP&Pol, FRACP & David L. Morris MBChB, FRCS, MD, PhD, FRACS

  2. St George & Sutherland Clinical School, University of New South Wales, Sydney, Australia

    Oliver M. Fisher MD, PhD & Mathew Kozman MBBS, MS, FRACS

  3. School of Medicine, University of Notre Dame, Sydney, Australia

    Oliver M. Fisher MD, PhD

  4. College of Medicine, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia

    Nayef Alzahrani MBBS, SBGS

  5. Cancer Care Clinic, St George Hospital, Sydney, Australia

    Winston Liauw MBBS, MMEDSCI, MP&Pol, FRACP

  6. Hepatobiliary and Surgical Oncology Unit, Department of Surgery, St George Hospital, Research and Education Centre, University of New South Wales, Kogarah, Sydney, NSW, Australia

    David L. Morris MBChB, FRCS, MD, PhD, FRACS

Authors
  1. Bhavneet Singh MBBS
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  2. Oliver M. Fisher MD, PhD
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  3. Gurkirat Singh MBBS
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  8. Winston Liauw MBBS, MMEDSCI, MP&Pol, FRACP
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Contributions

BS, OMF, GS, MAK, JL, MB, NA, WL, and DLM conception, design, acquisition, analysis, and interpretation of data. BS statistical analysis and interpretation of data. All authors drafting and revising of article content and final approval of manuscript prior to submission.

Corresponding author

Correspondence to David L. Morris MBChB, FRCS, MD, PhD, FRACS.

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Singh, B., Fisher, O.M., Singh, G. et al. Short- and Long-Term Outcomes of Patients Requiring Gastrectomy During Cytoreductive Surgery and Intraperitoneal Chemotherapy for Lower-Gastrointestinal Malignancies: A Propensity Score-Matched Analysis. Ann Surg Oncol 26, 3627–3635 (2019). https://doi.org/10.1245/s10434-019-07510-9

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