Abstract
MicroRNAs (miRNAs), a class of small, regulatory, non-coding RNA molecules, display aberrant expression patterns and functional abnormalities in human diseases including cancers. This review summarizes the abnormally expressed miRNAs in various types of human cancers, possible mechanisms underlying such abnormalities, and miRNA-modulated molecular pathways critical for cancer development. Practical implications of miRNAs as biomarkers, novel drug targets and therapeutic tools for diagnosis, prognosis, and treatments of human cancers are also discussed.
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Grant supports
A Ministry of Science and Technology of China grant ([973]2005CB724605); a Natural Science Foundation of China grant (30872930); and a grant from the Science and Technology Department of the Zhuhai Municipality of Guangdong Province (PC20071076) to M.-F. Li; grants from the National Institutes of Health (CA102011, CA130966), American Cancer Society (RSG CSM-107144) and the Hillman Fellows Program for Innovative Cancer Research to S.-Y. Cheng.
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Li, M., Li, J., Ding, X. et al. microRNA and Cancer. AAPS J 12, 309–317 (2010). https://doi.org/10.1208/s12248-010-9194-0
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DOI: https://doi.org/10.1208/s12248-010-9194-0