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Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases

  • Review Article
  • Theme: Natural Products Drug Discovery in Cancer Prevention
  • Published:
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Abstract

The etiology of most human diseases involves complicated interactions of multiple environmental factors with individual genetic background which is initially generated early in human life, for example, during the processes of embryogenesis and fetal development in utero. Early embryogenesis includes a series of programming processes involving extremely accurate time-controlled gene activation/silencing expressions, and epigenetic control is believed to play a key role in regulating early embryonic development. Certain dietary components with properties in influencing epigenetic processes are believed to have preventive effects on many human diseases such as cancer. Evidence shows that in utero exposure to certain epigenetic diets may lead to reprogramming of primary epigenetic profiles such as DNA methylation and histone modifications on the key coding genes of the fetal genome, leading to different susceptibility to diseases later in life. In this review, we assess the current advances in dietary epigenetic intervention on transgenerational human disease control. Enhanced understanding of the important role of early life epigenetics control may lead to cost-effective translational chemopreventive potential by appropriate administration of prenatal and/or postnatal dietary supplements leading to early disease prevention.

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Abbreviations

DNMT:

DNA methyltransferase

HDACs:

Histone deacetylases

HATs:

Histone acetyltransferases

SFN:

Sulforaphane

EGCG:

(−)-Epigallocatechin-3-gallate

SAM:

S-adenosylmethionine

NTDs:

Neural tube defects

ER:

Estrogen receptor

NCDs:

Noncommunicable diseases

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ACKNOWLEDGMENTS

This work was supported by grants from the American Institute for Cancer Research.

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The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA

    Yuanyuan Li, Sabita N. Saldanha & Trygve O. Tollefsbol

  2. Center for Aging, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA

    Trygve O. Tollefsbol

  3. Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA

    Trygve O. Tollefsbol

  4. Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA

    Trygve O. Tollefsbol

  5. Department of Math and Sciences, Alabama State University, P.O. Box 271, Montgomery, Alabama, 36101-0271, USA

    Sabita N. Saldanha

  6. CH 175, 1300 University Boulevard, Birmingham, Alabama, 35294-1170, USA

    Yuanyuan Li

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  1. Yuanyuan Li
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  2. Sabita N. Saldanha
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Correspondence to Yuanyuan Li.

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Guest Editors: Ah-Ng Tony Kong and Chi Chen

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Li, Y., Saldanha, S.N. & Tollefsbol, T.O. Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases. AAPS J 16, 27–36 (2014). https://doi.org/10.1208/s12248-013-9538-7

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