Abstract
ABSTRACT: Our study tests the hypothesis that hyperviscosity independent of arterial O2 content reduces cerebral cortical blood flow, O2 delivery, and O2 uptake. After baseline determinations, ten 2− to 4-day-old awake spontaneously breathing piglets were given an intravenous infusion (5 ml · kg-1, body weight) of concentrated cyroprecipitate, whereas eight controls received normal saline. Cerebral cortical blood flow, arterial and superior sagittal sinus O2 content, whole blood viscosity, hematocrit, blood gases, and plasma fibrinogen concentrations were measured at baseline and 3 h after infusion. No significant changes were observed in the control group. Three hours after the infusion of concentrated cryoprecipitate the experimental group showed an increase in whole blood viscosity, whereas hematocrit and arterial O2 content were unchanged. There was a decrease in cerebral cortical blood flow and cerebral cortical O2 delivery, whereas cerebral cortical O2 uptake was unchanged. We conclude that hyperviscosity independent of arterial O2 content reduces cerebral cortical blood flow and that although O2 delivery was reduced in the newborn piglet cerebral cortical O2 uptake was maintained.
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Goldstein, M., Stonestreet, B., Brann, B. et al. Cerebral Cortical Blood Flow and Oxygen Metabolism in Normocythemic Hyperviscous Newborn Piglets. Pediatr Res 24, 486–489 (1988). https://doi.org/10.1203/00006450-198810000-00014
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DOI: https://doi.org/10.1203/00006450-198810000-00014
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