Abstract
Summary: Posthepatic insulin availability has been evaluated by steadystate insulin turnover studies with 131I-insulin. Spontaneously delivered term (age 3.3 ± 0.8 days) (mean ± S.E.) and prematurely delivered lambs (betamathasone treated at 132 days) (age, 1.1 ± 0.2 days) were compared with 4− to 5-month-old sheep. After a 7-hr fast, animals received 0.45% saline or 5.7 mg/kg/min glucose (0.06 ml/kg/min) for 6-hr followed by the tracer insulin infusion for 110 min. Plasma glucose, insulin, and immunoprecipitable insulin were measured sequentially during the steady state. Endogenous posthepatic insulin secretion and metabolic clearance rates were derived. Neither endogenous posthepatic insulin secretion rates nor metabolic clearance rates were different among the three groups of animals when either 0.45% saline or 5.7 mg/kg/min exogenous glucose infusions were compared. Secretory response of the pancreatic β cell to continuous glucose infusion seems similar for the term and preterm lamb when compared to adult sheep.
Speculation: Secretory capability of the pancreatic fl cell does not account for imprecise control of endogenous glucose production previously noted in a neonatal lamb model.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cowett, R., Susa, J., Warburton, D. et al. Endogenous Posthepatic Insulin Secretion and Metabolic Clearance Rates in the Neonatal Lamb. Pediatr Res 14, 1391–1394 (1980). https://doi.org/10.1203/00006450-198012000-00027
Issue Date:
DOI: https://doi.org/10.1203/00006450-198012000-00027
Keywords
This article is cited by
-
Relationship between the level of plasma insulin and lipid profile in Iranian fat-tailed sheep
Comparative Clinical Pathology (2011)