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Androgen Receptor Coregulator CTBP1-AS Is Associated With Polycystic Ovary Syndrome in Chinese Women: A Preliminary Study

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Abstract

Polycystic ovary syndrome (PCOS) is currently considered a predominantly hyperandrogenic syndrome. In theory, hyperandrogenism can be caused by high level of testosterone (T) as well as by enhanced androgen receptor (AR) activity. C-Terminal binding protein 1 antisense (CTBP1-AS) was a novel long noncoding RNA (lncRNA) to regulate AR activity. In this study, we found that expression level of CTBP1-AS in peripheral blood leukocytes was significantly higher in women with PCOS than that in controls after adjustment for age and body mass index (BMI). Individuals having higher expression of CTBP1-AS had significantly greater disease risk than those having lower expression. We also identified expression of CTBP1-AS as an independent risk factor for PCOS. A positive correlation was observed between the CTBP1-AS expression and the total T (TT) concentration either unadjusted or after adjusting for age, BMI, and homeostatic model assessment insulin resistance. Taken together, our current study presented the first evidence that the lncRNA CTBP1-AS, a novel AR modulator, is associated with PCOS in Chinese population and established the possibility that abnormal CTBP1-AS expression is a risk factor for PCOS and it is a predictor of variability in serum TT level in Chinese women with PCOS.

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Authors and Affiliations

  1. Medical College of Qingdao University, Qingdao, China

    Zhenteng Liu MD

  2. Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College of Qingdao University, 20 Yuhuangding East Rd, 264000, Yantai, Shandong, China

    Zhenteng Liu MD, Cuifang Hao PhD, Dehua Song MD, Ning Zhang PhD, Hongchu Bao PhD & Qinglan Qu MD

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  1. Zhenteng Liu MD
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  2. Cuifang Hao PhD
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Correspondence to Cuifang Hao PhD.

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Liu, Z., Hao, C., Song, D. et al. Androgen Receptor Coregulator CTBP1-AS Is Associated With Polycystic Ovary Syndrome in Chinese Women: A Preliminary Study. Reprod. Sci. 22, 829–837 (2015). https://doi.org/10.1177/1933719114565037

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