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Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents

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Abstract

Vitamin D is linked to a number of adverse pregnancy outcomes through largely unknown mechanisms. This study was conducted to examine the role of vitamin D status in metabolomic profiles in a group of 30 pregnant, African American adolescents (17.1 ± 1.1 years) at midgestation (26.8 ± 2.8 weeks), in 15 adolescents with 25-hydroxy vitamin D (25(OH)D) ≥20 ng/mL, and in 15 teens with 25(OH)D <20 ng/mL. Serum metabolomic profiles were examined using gas chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry. A novel hierarchical mixture model was used to evaluate differences in metabolite profiles between low and high groups. A total of 326 compounds were identified and included in subsequent statistical analyses. Eleven metabolites had significantly different means between the 2 vitamin D groups, after correcting for multiple hypothesis testing: pyridoxate, bilirubin, xylose, and cholate were higher, and leukotrienes, 1,2-propanediol, azelate, undecanedioate, sebacate, inflammation associated complement component 3 peptide (HWESASXX), and piperine were lower in serum from adolescents with 25(OH)D ≥20 ng/mL. Lower maternal vitamin D status at midgestation impacted serum metabolic profiles in pregnant adolescents.

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References

  1. Holmes VA, Barnes MS, Alexander HD, McFaul P, Wallace JM. Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr. 2009;102(6):876–881.

    Article  PubMed  CAS  Google Scholar 

  2. O’Riordan MN, Kiely M, Higgins JR, Cashman KD. Prevalence of suboptimal vitamin D status during pregnancy. Ir Med J. 2008;101(8):240, 242–243.

    Google Scholar 

  3. Finkelstein JL, Mehta S, Duggan CP, et al. Predictors of anaemia and iron deficiency in HIV-infected pregnant women in Tanzania: a potential role for vitamin D and parasitic infections. Public Health Nutr. 2012;15(5):928–937.

    Article  PubMed  Google Scholar 

  4. Prentice A, Jarjou LM, Goldberg GR, Bennett J, Cole TJ, Schoen-makers I. Maternal plasma 25-hydroxyvitamin D concentration and birthweight, growth and bone mineral accretion of Gambian infants. Acta Paediatrica. 2009;98(8):1360–1362.

    Article  PubMed  CAS  Google Scholar 

  5. Mehta S, Spiegelman D, Aboud S, et al. Lipid-soluble vitamins A, D, and E in HIV-infected pregnant women in Tanzania. Eur J Clin Nutr. 2010;64(8):808–817.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  6. Brannon PM, Picciano MF. Vitamin D in pregnancy and lactation in humans. Ann Rev Nutr. 2011;31:89–115.

    Article  CAS  Google Scholar 

  7. Davis LM, Chang SC, Mancini J, Nathanson MS, Witter FR, O’Brien KO. Vitamin D insufficiency is prevalent among pregnant African American adolescents. J Pediatr Adolesc Gynecol. 2010;23(1):45–52.

    Article  PubMed  Google Scholar 

  8. Young BE, McNanley TJ, Cooper EM, et al. Vitamin D insufficiency is prevalent and vitamin D is inversely associated with parathyroid hormone and calcitriol in pregnant adolescents. J Bone Miner Res. 2012;27(1):177–186.

    Article  PubMed  CAS  Google Scholar 

  9. Grover SR, Morley R. Vitamin D deficiency in veiled or darkskinned pregnant women. Med J Aust. 2001;175(5):251–252.

    Article  PubMed  CAS  Google Scholar 

  10. van der Meer IM, Karamali NS, Boeke AJ, et al. High prevalence of vitamin D deficiency in pregnant non-Western women in The Hague, Netherlands. Am J Clin Nutr. 2006;84(2):350–353; quiz 468–359.

    Article  PubMed  Google Scholar 

  11. Alfaham M, Woodhead S, Pask G, Davies D. Vitamin D deficiency: a concern in pregnant Asian women. Br J Nutr. 1995;73(6):881–887.

    Article  PubMed  CAS  Google Scholar 

  12. Kazemi A, Sharifi F, Jafari N, Mousavinasab N. High prevalence of vitamin D deficiency among pregnant women and their newborns in an Iranian population. J Womens Health. 2009;18(6): 835–839.

    Article  Google Scholar 

  13. Sachan A, Gupta R, Das V, Agarwal A, Awasthi PK, Bhatia V. High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr. 2005;81(5): 1060–1064.

    Article  PubMed  CAS  Google Scholar 

  14. Dasgupta A, Saikia U, Sarma D. Status of 25(OH)D levels in pregnancy: A study from the North Eastern part of India. Indian J Endocrinol Metabol. 2012;16(suppl 2):S405–S407.

    CAS  Google Scholar 

  15. Young BE, McNanley TJ, Cooper EM, et al. Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents. Am J Clin Nutr. 2012;95(5): 1103–1112.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  16. Evans KN, Bulmer JN, Kilby MD, Hewison M. Vitamin D and placental-decidual function. J Soc Gynecol Investig. 2004;11(5): 263–271.

    Article  PubMed  CAS  Google Scholar 

  17. Evans KN, Nguyen L, Chan J, et al. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol Reprod. 2006;75(6):816–822.

    Article  PubMed  CAS  Google Scholar 

  18. Kumar R, Cohen WR, Silva P, Epstein FH. Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J Clin Invest. 1979;63(2):342–344.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Liu NQ, Hewison M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys. 2012;523(1):37–47.

    Article  PubMed  CAS  Google Scholar 

  20. Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Kusel MM, Hart PH. Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics. 2012;129(3): 485–493.

    Article  PubMed  Google Scholar 

  21. Sorensen IM, Joner G, Jenum PA, Eskild A, Torjesen PA, Stene LC. Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes. 2012;61(1):175–178.

    Article  PubMed  CAS  Google Scholar 

  22. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab. 2007;92(9): 3517–3522.

    Article  PubMed  CAS  Google Scholar 

  23. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol. 2010;203(4):366, e361–e366.

    Article  CAS  Google Scholar 

  24. Powe CE, Seely EW, Rana S, et al. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension. 2010;56(4):758–763.

    Article  PubMed  CAS  Google Scholar 

  25. Baker AM, Haeri S, Camargo CA Jr, Espinola JA, Stuebe AM. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab. 2010;95(11):5105–5109.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  26. Ma R, Gu Y, Zhao S, Sun J, Groome LJ, Wang Y. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Am J Physiol Endocrinol Metab. 2012;303(7): E928–E935.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Brannon PM. Vitamin D and adverse pregnancy outcomes: beyond bone health and growth. Proc Nutr Soc. 2012;71(2): 205–212.

    Article  PubMed  CAS  Google Scholar 

  28. Urrutia RP, Thorp JM. Vitamin D in pregnancy: current concepts. Curr Opin Obstet Gynecol. 2012;24(2):57–64.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Chang SC, O’Brien KO, Nathanson MS, Mancini J, Witter FR. Characteristics and risk factors for adverse birth outcomes in pregnant black adolescents. J Pediatr. 2003;143(2): 250–257.

    Article  PubMed  Google Scholar 

  30. Bodnar LM, Krohn MA, Simhan HN. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr. 2009;139(6):1157–1161.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  31. Hensel KJ, Randis TM, Gelber SE, Ratner AJ. Pregnancy-specific association of vitamin D deficiency and bacterial vaginosis. Am J Obstet Gynecol. 2011;204(1):41, e41–e49.

    Article  CAS  Google Scholar 

  32. Scholl TO, Chen X. Vitamin D intake during pregnancy: association with maternal characteristics and infant birth weight. Early Hum Dev. 2009;85(4):231–234.

    Article  PubMed  CAS  Google Scholar 

  33. Marya RK, Rathee S, Dua V, Sangwan K. Effect of vitamin D supplementation during pregnancy on foetal growth. Indian J Med Res. 1988;88:488–492.

    PubMed  CAS  Google Scholar 

  34. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;26(10):2341–2357.

    Article  PubMed  CAS  Google Scholar 

  35. Hollis BW, Wagner CL. Vitamin D and pregnancy: skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2013;92(2):128–139.

    Article  PubMed  CAS  Google Scholar 

  36. Finkelstein JL, Mehta S, Duggan C, et al. Maternal vitamin D status and child morbidity, anemia, and growth in human immunodeficiency virus-exposed children in Tanzania. Pediatr Infect Dis J. 2012;31(2):171–175.

    Article  PubMed  Google Scholar 

  37. Litonjua AA, Weiss ST. Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol. 2007;120(5): 1031–1035.

    Article  PubMed  CAS  Google Scholar 

  38. Brehm JM, Schuemann B, Fuhlbrigge AL, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 2010;126(1):52–58. e55.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  39. Walker VP, Modlin RL. The vitamin D connection to pediatric infections and immune function. Pediatr Res. 2009;65(5 pt 2): 106R–113R.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Bouillon R, Van Schoor NM, Gielen E, et al. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metabol. 2013;98(8):E1283–E1304.

    Article  CAS  Google Scholar 

  41. Holick MF. Evidence-based D-bate on health benefits of vitamin D revisited. Dermatoendocrinology. 2012;4(2):183–190.

    Article  CAS  Google Scholar 

  42. Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr. 1995;61(3 suppl): 638S–645S.

    Article  PubMed  CAS  Google Scholar 

  43. Elnenaei MO, Chandra R, Mangion T, Moniz C. Genomic and metabolomic patterns segregate with responses to calcium and vitamin D supplementation. Br J Nutr. 2011;105(1):71–79.

    Article  PubMed  CAS  Google Scholar 

  44. O’Brien KO, Donangelo CM, Ritchie LD, Gildengorin G, Abrams S, King JC. Serum 1, 25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period. Am J Clin Nutr. 2012;96(1):64–72.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  45. O’Brien KO, Li S, Cao C, et al. Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones. J Clin Endocrinol Metabol. 2014;99(4):1348–1356.

    Article  CAS  Google Scholar 

  46. Young BE, Cooper EM, McIntyre AW, et al. Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents. FASEB J. 2014;28(5):2029–2037.

    Article  PubMed  CAS  Google Scholar 

  47. Whisner CM, Young BE, Witter FR, et al. Reductions in heel bone quality across gestation are attenuated in pregnant adolescents with higher pre-pregnancy weight and greater increases in PTH across gestation. J Bone Miner Res. 2014;29(9):2109–2117.

    Article  PubMed  CAS  Google Scholar 

  48. Essley BV, McNanley T, Cooper EM, et al. Osteoprotegerin differs by race and is related to infant birth weight z-score in pregnant adolescents. J Dev Orig Health Dis. 2011;2(5):272–279.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  49. Bar HY, Booth JG, Wells MT. A mixture-model approach for parallel testing for unequal variances. Stat Appl Genet Mol Biol. 2012;11(1):Article 8.

    Article  PubMed  Google Scholar 

  50. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005;135(2):317–322.

    Article  PubMed  CAS  Google Scholar 

  51. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3): 266–281.

    Article  PubMed  CAS  Google Scholar 

  52. Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med. 1989;8(5):551–561.

    Article  PubMed  CAS  Google Scholar 

  53. Govindarajulu US, Spiegelman D, Thurston SW, Ganguli B, Eisen EA. Comparing smoothing techniques in Cox models for exposure-response relationships. Stat Med. 2007;26(20): 3735–3752.

    Article  PubMed  Google Scholar 

  54. Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health. 1989;79(3):340–349.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  55. Sonnenburg JL, Chen CT, Gordon JI. Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host. PLoS Biol. 2006;4(12):e413.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  56. Pokusaeva K, Fitzgerald GF, van Sinderen D. Carbohydrate metabolism in Bifidobacteria. Genes Nutr. 2011;6(3):285–306.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  57. Heazell AE, Bernatavicius G, Warrander L, Brown MC, Dunn WB. A metabolomic approach identifies differences in maternal serum in third trimester pregnancies that end in poor perinatal outcome. Reprod Sci. 2012;19(8):863–875.

    Article  PubMed  CAS  Google Scholar 

  58. Conde-Agudelo A, Papageorghiou AT, Kennedy SH, Villar J. Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta-analysis. BJOG. 2013;120(6): 681–694.

    Article  PubMed  CAS  Google Scholar 

  59. O’sullivan A, Gibney MJ, Connor AO, et al. Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome. Mol Nutr Food Res. 2011;55(5):679–690.

    Article  PubMed  CAS  Google Scholar 

  60. Carraro S, Giordano G, Reniero F, et al. Asthma severity in childhood and metabolomic profiling of breath condensate. Allergy. 2013;68(1):110–117.

    Article  PubMed  CAS  Google Scholar 

  61. Fischer R, Trudgian DC, Wright C, et al. Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis. Mol Cell Proteomics. 2012;11(2):M111 013904.

    Article  PubMed  CAS  Google Scholar 

  62. Oberbach A, Bluher M, Wirth H, et al. Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. J Proteome Res. 2011;10(10):4769–4788.

    Article  PubMed  CAS  Google Scholar 

  63. Weber G, Heilborn JD, Chamorro Jimenez CI, Hammarsjo A, Torma H, Stahle M. Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Investig Dermatol. 2005;124(5): 1080–1082.

    Article  PubMed  CAS  Google Scholar 

  64. Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3). J Cyst Fibros. 2007;6(6):403–410.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  65. Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007;179(4):2060–2063.

    Article  PubMed  CAS  Google Scholar 

  66. Diaz L, Noyola-Martinez N, Barrera D, et al. Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts. J Reprod Immunol. 2009;81(1):17–24.

    Article  PubMed  CAS  Google Scholar 

  67. Yang S, Smith C, Prahl JM, Luo X, DeLuca HF. Vitamin D deficiency suppresses cell-mediated immunity in vivo. Arch Biochem Biophys. 1993;303(1):98–106.

    Article  PubMed  CAS  Google Scholar 

  68. Bar-Shavit Z, Noff D, Edelstein S, Meyer M, Shibolet S, Goldman R. 1,25-dihydroxyvitamin D3 and the regulation of macrophage function. Calcif Tissue Int. 1981;33(6):673–676.

    Article  PubMed  CAS  Google Scholar 

  69. Mariani E, Ravaglia G, Forti P, et al. Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians. Clin Exp Immunol. 1999;116(1):19–27.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  70. Yin Y, Yu Z, Xia M, Luo X, Lu X, Ling W. Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism. Eur J Clin Investig. 2012;42(11): 1189–1196.

    Article  CAS  Google Scholar 

  71. Wong KE, Szeto FL, Zhang W, et al. Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am J Phys. 2009;296(4):E820–828.

    CAS  Google Scholar 

  72. Wong KE, Kong J, Zhang W, et al. Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J Biol Chem. 2011;286(39): 33804–33810.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  73. Davis WL, Matthews JL, Goodman DB. Glyoxylate cycle in the rat liver: effect of vitamin D3 treatment. FASEB J. 1989;3(5): 1651–1655.

    Article  PubMed  CAS  Google Scholar 

  74. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC. Regulation of adiposity by dietary calcium. FASEB J. 2000;14(9): 1132–1138.

    Article  PubMed  CAS  Google Scholar 

  75. Barengolts E. Vitamin D and prebiotics may benefit the intestinal microbacteria and improve glucose homeostasis in prediabetes and type 2 diabetes. Endocr Pract. 2013;19(3):497–510.

    Article  PubMed  Google Scholar 

  76. Ly NP, Litonjua A, Gold DR, Celedon JC. Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol. 2011;127(5): 1087–1094; quiz 1095–1086.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  77. Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Ann Rev Nutr. 2003;23:117–145.

    Article  CAS  Google Scholar 

  78. Adorini L, Penna G. Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists. Hum Immunol. 2009;70(5):345–352.

    Article  PubMed  CAS  Google Scholar 

  79. Yu S, Bruce D, Froicu M, Weaver V, Cantorna MT. Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice. Proc Natl Acad Sci U S A. 2008;105(52): 20834–20839.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Wu S, Liao AP, Xia Y, et al. Vitamin D receptor negatively regulates bacterial-stimulated NF-kappaB activity in intestine. Am J Pathol. 2010;177(2):686–697.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  81. Mai V, McCrary QM, Sinha R, Glei M. Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteers. Nutr J. 2009;8:49.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  82. Yetgin S, Ozsoylu S, Ruacan S, Tekinalp G, Sarialioglu F. Vitamin D-deficiency rickets and myelofibrosis. J Pediatr. 1989;114(2):213–217.

    Article  PubMed  CAS  Google Scholar 

  83. Kendrick J, Smits G, Chonchol M. 25-Hydroxyvitamin D and inflammation and its association with hemoglobin levels in chronic kidney disease. Paper presented at: National Kidney Foundation Spring Clinical Meetings; April 2008; Dallas, TX.

  84. Lawson M, Thomas M. Vitamin D concentrations in Asian children aged 2 years living in England: population survey. BMJ. 1999;318(7175):28.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  85. Grindulis H, Scott PH, Belton NR, Wharton BA. Combined deficiency of iron and vitamin D in Asian toddlers. Arch Dis Child. 1986;61(9):843–848.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Nutritional Sciences, Cornell University, 230 Savage Hall, 14853, Ithaca, NY, USA

    Julia L. Finkelstein MPH, SM, ScD, Tera R. Kent BS &  Kimberly O. O’Brien PhD

  2. Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA

    Eva K. Pressman MD & Elizabeth M. Cooper EdD

  3. Department of Statistics, University of Connecticut, Storrs, CT, USA

    Haim Y. Bar PhD

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  1. Julia L. Finkelstein MPH, SM, ScD
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  2. Eva K. Pressman MD
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  3. Elizabeth M. Cooper EdD
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Finkelstein, J.L., Pressman, E.K., Cooper, E.M. et al. Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents. Reprod. Sci. 22, 685–695 (2015). https://doi.org/10.1177/1933719114556477

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