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Correlation of Human Leukocyte Antigen-G (HLA-G) Expression and Disease Progression in Epithelial Ovarian Cancer

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Abstract

Human leukocyte antigen-G (HLA-G) expression has been reported to be relevant to cancer development and immune tolerance. The purpose of this study was to investigate the correlation between HLA-G expression and disease progression and to assess the use of HLA-G expression as a prognostic immunomarker in epithelial ovarian carcinoma. Human leukocyte antigen-G expression in 41 ovarian cancer tissues and 8 normal ovarian tissues was analyzed using immunohistochemistry and Western blot assay. Quantitative real-time reverse transcription polymerase chain reaction (RT-PCR) was used for HLA-G messenger RNA (mRNA) expression. Human leukocyte antigen-G mRNA and protein levels were significantly greater in advanced ovarian cancer tissues than in normal or early stage ovarian cancer tissues (P < .05 and P < .05, respectively). Patients with HLA-G expression had a significantly worse prognosis. There is a significant correlation between HLA-G immunoreactivity and patient survival in univariate analysis (P = .04). Our data was consistent with the concept that HLA-G expression might play a pivotal role in the development and disease progression of epithelial ovarian cancer.

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References

  1. Ugurel S, Rebmann V, Ferrone S, Tilgen W, Grosse-Wilde H, Reinhold U. Soluble human leukocyte antigen-G serum level is elevated in melanoma patients and is further increased by interferon-alpha immunotherapy. Cancer. 2001;92(2):369–376.

    Article  CAS  Google Scholar 

  2. Paul P, Rouas-Freiss N, Khalil-Daher I, et al. HLA-G expression in melanoma: a way for tumor cells to escape from immunosurveillance. Proc Natl Acad Sci USA. 1998;95(8): 4510–4515.

    Article  CAS  Google Scholar 

  3. Lin A, Yan WH, Xu HH, et al. HLA-G expression in human ovarian carcinoma counteracts NK cell function. Ann Oncol. 2007;18(11):1804–1809.

    Article  CAS  Google Scholar 

  4. Lefebvre S, Antoine M, Uzan S, et al. Specific activation of the non-classical class I histocompatibility HLA-G antigen and expression of the ILT2 inhibitory receptor in human breast cancer. J Pathol. 2002;196(3):266–274.

    Article  CAS  Google Scholar 

  5. Rouas-Freiss N, Moreau P, Ferrone S, Carosella ED. HLA-G proteins in cancer: do they provide tumor cells with an escape mechanism? Cancer Res. 2005;65(22):10139–10144.

    Article  CAS  Google Scholar 

  6. Tripathi P, Agrawal S. Non-classical HLA-G antigen and its role in the cancer progression. Cancer Invest. 2006;24(2): 178–186.

    Article  CAS  Google Scholar 

  7. Nückel H, Rebmann V, Dürig J, Dührsen U, Grosse-Wilde H. HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia. Blood. 2005;105(4):1694–1698.

    Article  Google Scholar 

  8. Urosevic M, Kurrer MO, Kamarashev J, et al. Human leukocyte antigen G up-regulation in lung cancer associates with high-grade histology, human leukocyte antigen class I loss and interleukin-10 production. Am J Pathol. 2001;159(3):817–824.

    Article  CAS  Google Scholar 

  9. Ye SR, Yang H, Li K, Dong DD, Lin XM, Yie SM. Human leukocyte antigen G expression: as a significant prognostic indicator for patients with colorectal cancer. Mod Pathol. 2007;20(3):375–383.

    Article  CAS  Google Scholar 

  10. Yie SM, Yang H, Ye SR, Li K, Dong DD, Lin XM. Expression of human leukocyte antigen G (HLA-G) correlates with poor prognosis in gastric carcinoma. Ann Surg Oncol. 2007;14(10):2721–2719.

    Article  Google Scholar 

  11. Yie SM, Yang H, Ye SR, et al. Expression of HLA-G is associated with prognosis in esophageal squamous cell carcinoma. Am J Clin Pathol. 2007;128(6):1002–1009.

    Article  Google Scholar 

  12. Yoon BS, Kim YT, Kim JW, Kim SH, Kim JH, Kim SW. Expression of human leukocyte antigen-G and its correlation with interleukin-10 expression in cervical carcinoma. Int J Gynecol Obstet. 2007;98(1):48–53.

    Article  CAS  Google Scholar 

  13. Singer G, Rebmann V, Chen YC, et al. HLA-G is a potential tumor marker in malignant ascites. Clin Cancer Res. 2003;9(12):4460–4464.

    CAS  PubMed  Google Scholar 

  14. Sheu JJ, Shih IeM. Clinical and biological significance of HLA-G expression in ovarian cancer. Semin Cancer Biol. 2007;17(6):436–443.

    Article  CAS  Google Scholar 

  15. Naji A, Durrbach A, Carosella ED, Rouas-Freiss N. Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2/ILT-4/FasL-mediated pathways. Hum Immunol. 2007;68(4):233–239.

    Article  CAS  Google Scholar 

  16. Davidson B, Elstrand MB, McMaster MT, et al. HLA-G expression in effusions is a possible marker of tumor susceptibility to chemotherapy in ovarian carcinoma. Gynecol Oncol. 2005;96(1):42–47.

    Article  CAS  Google Scholar 

  17. Urosevic M, Dummer R. Human leukocyte antigen-G and cancer immunoediting. Cancer Res. 2008;68(3):627–630.

    Article  CAS  Google Scholar 

  18. Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol. 2006;6(10):715–727.

    Article  CAS  Google Scholar 

  19. Yie SM, Yang H, Ye SR, Li K, Dong DD, Lin Xm. Expression of human leucocyte antigen G (HLA-G) is associated with prognosis in non-small cell lung cancer. Lung Cancer. 2007;58(2):267–274.

    Article  Google Scholar 

  20. Barrier BF, Kendall BS, Sharpe-Timms KL, Kost ER. Characterization of human leukocyte antigen-G (HLA-G) expression in endometrial adenocarcinoma. Gynecol Oncol. 2006;103(1):25–30.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Women’s Cancer Clinic, Yonsei University College of Medicine, Shinchon-dong 134, Seodaemun-gu, Seoul, 120-752, South Korea

    Yong Wook Jung MD, Young Tea Kim MD, PhD, Sang Wun Kim MD, PhD, Sunghoon Kim MD, PhD & Jae Hoon Kim MD, PhD

  2. Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea

    Nam Hoon Cho MD, PhD

  3. Department of Obstetrics and Gynecology, Kwandong University College of Medicine, Myongji hospital, Goyang, Korea

    Jae Wook Kim MD, PhD

Authors
  1. Yong Wook Jung MD
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  2. Young Tea Kim MD, PhD
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  3. Sang Wun Kim MD, PhD
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  4. Sunghoon Kim MD, PhD
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  5. Jae Hoon Kim MD, PhD
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  6. Nam Hoon Cho MD, PhD
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  7. Jae Wook Kim MD, PhD
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Correspondence to Young Tea Kim MD, PhD.

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Jung, Y.W., Kim, Y.T., Kim, S.W. et al. Correlation of Human Leukocyte Antigen-G (HLA-G) Expression and Disease Progression in Epithelial Ovarian Cancer. Reprod. Sci. 16, 1103–1111 (2009). https://doi.org/10.1177/1933719109342131

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  • DOI: https://doi.org/10.1177/1933719109342131

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