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Computer modeling of transketolase-like protein, TKTL1, a marker of certain tumor tissues

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Abstract

A computer model of the spatial structure of transketolase-like protein (TKTL1), a marker of certain tumor tissues, has been constructed using the known spatial structure of transketolase found in normal human tissues. The structure of the two proteins at all levels of their organization has also been compared. On the basis of the revealed differences in structures of these proteins, we assume it is unlikely that TKTL1 can be a thiamine diphosphate-dependent protein capable of catalyzing the transketolase reaction.

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Abbreviations

hTK:

transketolase of normal human tissue

R5P:

ribose 5-phosphate

sTK:

transketolase of Saccharomyces cerevisiae

TDP:

thiamine diphosphate

TK:

transketolase

TKTL1:

transketolase-like protein 1

X5P:

xylulose 5-phosphate

References

  1. Schenk, G., Duggleby, R., and Nixon, P. (1998) Int. J. Biochem. Cell Biol., 30, 1297–1318.

    Article  PubMed  CAS  Google Scholar 

  2. McCool, B. A., Plonk, S. G., Martin, P. R., and Singleton, C. K. (1993) J. Biol. Chem., 268, 1397–1404.

    PubMed  CAS  Google Scholar 

  3. Kaufman, K. A., and Harper, C. (2009) Int. J. Biochem. Cell Biol., 41, 717–720.

    Article  Google Scholar 

  4. Obiol-Pardo, C., and Rubio-Martinez, J. (2009) J. Mol. Graph. Model., 27, 723–734.

    Article  PubMed  CAS  Google Scholar 

  5. Mitschke, L., Parthier, C., Schroder-Tittmann, K., Coy, J., Ludtke, S., and Tittmann, K. (2010) J. Biol. Chem., 285, 31559–31570.

    Article  PubMed  CAS  Google Scholar 

  6. Wang, J., Martin, P. R., and Singleton, C. K. (1997) Biochim. Biophys. Acta, 1341, 165–172.

    Article  PubMed  CAS  Google Scholar 

  7. Boros, L. G., Puigjaner, J., Cascante, M., Lee, W. N., Brandes, J. L., Bassilian, S., Yusuf, F. I., Williams, R. D., Muscarella, P., Melvin, W. S., and Schirmer, W. J. (1997) Cancer Res., 57, 4242–4248.

    PubMed  CAS  Google Scholar 

  8. Comin-Anduix, B., Boren, J., Martinez, S., Moro, C., Centelles, J. J., Trebukhina, R., Petushok, N., Lee, W. N., Boros, L. G., and Cascante, M. (2001) Eur. J. Biochem., 268, 4177–4182.

    Article  PubMed  CAS  Google Scholar 

  9. Rais, B., Comin, B., Puigjaner, J., Brandes, L., Creppy, E., Saboureau, D., Ennamany, R., Lee, W. N., Boros, L. G., and Cascante, M. (1999) FEBS Lett., 456, 113–118.

    Article  PubMed  CAS  Google Scholar 

  10. Coy, J. F., Dressler, D., Wilde, J., and Schubert, P. (2005) Clin. Lab., 51, 257–273.

    PubMed  CAS  Google Scholar 

  11. Zerilli, M., Amato, M. C., Martorana, A., Cabibi, D., Coy, J. F., Cappello, F., Pompei, G., Russo, A., Giordano, C., and Rodolico, V. (2008) Cancer, 113, 936–944.

    Article  PubMed  Google Scholar 

  12. Xiaojun, X., Zur Hausen, A., Coy, J. F., and Lochelt, M. (2009) Int. J. Cancer, 124, 1330–1337.

    Article  Google Scholar 

  13. Muller, Y. A., Lindqvist, Y., Furey, W., Schulz, G. E., Jordan, F., and Schneider, G. (1993) Structure, 15, 95–103.

    Article  Google Scholar 

  14. Foldi, M., Stickeler, E., Bau, L., Kretz, O., Waterman, D., Gitsch, G., Kayser, G., Zur Hausen, A., and Coy, J. F. (2007) Oncol. Rep., 4, 841–845.

    Google Scholar 

  15. Schneider, G., and Lindqvist, Y. (1998) Biochim. Biophys. Acta, 1385, 387–398.

    Article  PubMed  CAS  Google Scholar 

  16. Nikkola, M., Lindqvist, Y., and Schneider, G. (1994) J. Mol. Biol., 238, 387–404.

    Article  PubMed  CAS  Google Scholar 

  17. Fiser, A., and Sali, A. (2003) Methods Enzymol., 374, 463–493.

    Google Scholar 

  18. Emsley, P., Lohkamp, B., Scott, W., and Cowtan, K. (2010) Acta Crystallogr. Sec. D. Biol. Crystallogr., 66, 486–501.

    Article  CAS  Google Scholar 

  19. Holtje, H. D., Sippl, W., Rognan, D., and Folkers, D. (2008) Molecular Modeling. Basic Principles and Applications, 3rd Edn., VCH, New York.

    Google Scholar 

  20. Case, D. A., Cheatham, T. E., Darden, T., Gohlke, H., Luo, R., Merz, K. M., Jr., Onufriev, A., Simmerling, C., Wang, B., and Woods, R. (2005) J. Comput. Chem., 26, 1668–1688.

    Article  PubMed  CAS  Google Scholar 

  21. Vriend, G, A. (1990) J. Mol. Graph., 8, 52–56.

    Article  PubMed  CAS  Google Scholar 

  22. Kern, D., Kern, G., Neef, H., Tittmann, K., Killenberg-Jabs, M., Wikner, C., Schneider, G., and Hubner, G. (1997) Science, 275, 67–70.

    Article  PubMed  CAS  Google Scholar 

  23. Kaplun, A., Binshtein, E., Vyazmensky, M., Steinmetz, A., Barak, Z., Chipman, D. M., Tittmann, K., and Shaanan, B. (2008) Nat. Chem. Biol., 4, 113–118.

    Article  PubMed  CAS  Google Scholar 

  24. Shaanan, B., and Chipman, D. (2009) FEBS J., 276, 2447–2453.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991, Moscow, Russia

    A. O. Maslova

  2. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    L. E. Meshalkina & G. A. Kochetov

Authors
  1. A. O. Maslova
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  2. L. E. Meshalkina
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  3. G. A. Kochetov
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Corresponding author

Correspondence to L. E. Meshalkina.

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Published in Russian in Biokhimiya, 2012, Vol. 77, No. 3, pp. 372–376.

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Maslova, A.O., Meshalkina, L.E. & Kochetov, G.A. Computer modeling of transketolase-like protein, TKTL1, a marker of certain tumor tissues. Biochemistry Moscow 77, 296–299 (2012). https://doi.org/10.1134/S000629791203008X

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  • DOI: https://doi.org/10.1134/S000629791203008X

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