Minimally invasive and ex-vivo diagnostics of breast cancer tissues by fiber optic evanescent-wave Fourier transform IR (FEW-FTIR) spectroscopy

Natalia I. Afanasyeva; Sergei F. Kolyakov; Vjacheslav G. Artioushenko; Victor V. Sokolov; George A. Frank

doi:10.1117/12.305383

16 April 1998 Minimally invasive and ex-vivo diagnostics of breast cancer tissues by fiber optic evanescent-wave Fourier transform IR (FEW-FTIR) spectroscopy

Natalia I. Afanasyeva, Sergei F. Kolyakov, Vjacheslav G. Artioushenko, Victor V. Sokolov, George A. Frank

Author Affiliations +

Proceedings Volume 3250, Optical Biopsy II; (1998) https://doi.org/10.1117/12.305383
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Fourier transform IR fiberoptic evanescent wave spectroscopy has been suggested as a powerful tool for clinical diagnostics of normal, precancerous, and cancerous breast tissue ex vivo and in vitro in the middle IR region of the spectrum. This method is suitable for noninvasive and direct measurements of the spectra of normal and pathological tissues in vitro, ex vivo and in vivo. For the first time this method has been used nondestructively, rapidly, fast and remotely in the operating rooms of clinics. The aim of our studies has been the express testing of various tumor tissues during surgery to optimize and localize an area of removing tissue. We measured very small samples of normal and malignant breast tissue ex vivo with a fiber bent to a special angle, forming a special tip probe configuration. We also suggest her the minimally invasive FTIR-FEW diagnosis tool using 'needle' changeable tip probe for biopsy applications. The spectral histopathology branching could be developed with help of this technique in vitro. The breast tissue at different stages of tumor or cancer has been distinguished very clearly in spectra of amide, cyclic and noncyclic hydrogen bonded fragments, phosphate groups and sugars.

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Natalia I. Afanasyeva, Sergei F. Kolyakov, Vjacheslav G. Artioushenko, Victor V. Sokolov, and George A. Frank "Minimally invasive and ex-vivo diagnostics of breast cancer tissues by fiber optic evanescent-wave Fourier transform IR (FEW-FTIR) spectroscopy", Proc. SPIE 3250, Optical Biopsy II, (16 April 1998); https://doi.org/10.1117/12.305383

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