Unlocking epigenetic codes in neurogenesis
Abstract
During embryonic and adult neurogenesis, neuronal stem cells follow a highly conserved path of differentiation to give rise to functional neurons at various developmental stages. Epigenetic regulation—including DNA modifications, histone modifications, and noncoding regulatory RNAs, such as microRNA (miRNA) and long noncoding RNA (lncRNA)—plays a pivotal role in embryonic and adult neurogenesis. Here we review the latest in our understanding of the epigenetic regulation in neurogenesis, with a particular focus on newly identified cytosine modifications and their dynamics, along with our perspective for future studies.
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↵1 Corresponding author
E-mail peng.jin{at}emory.edu
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.241547.114.
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