The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
- 1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA; 2Abramson Family Cancer Research Institute and Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; 3Division of Biological Sciences, University of California at San Diego, San Diego, California 92093, USA
Abstract
The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field.
Keywords
Footnotes
-
Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1243304.
-
↵4 Corresponding author. E-MAIL giaccia{at}stanford.edu; FAX (650) 723-7382.
- Cold Spring Harbor Laboratory Press
