RNA Genetics of Breast Cancer: Maspin as Paradigm
- R. Sager*,
- S. Sheng*,
- A. Anisowicz*,
- G. Sotiropoulou*,
- Z. Zou*,
- G. Stenman†,
- K. Swisshelm‡,
- Z. Chen*,
- M.J.C. Hendrix§,
- P. Pemberton**,
- K. Rafidi*, and
- K. Ryan*
- *Cancer Genetics, Dana Farber Cancer Institute, Boston, Massachusetts 02115; †Laboratory of Cancer Genetics, Department of Pathology, University of Goteborg, Sahlgrenska Hospital, S-413 45 Goteborg, Sweden; ‡University of Washington, Department of Pathology, Seattle, Washington 98195; §Pediatric Research Institute, Cardinal Glennon Children's Hospital, St. Louis University School of Medicine, St. Louis, Missouri 63110; **LXR Biotechnology, Inc., Richmond, California 94804
This extract was created in the absence of an abstract.
Excerpt
The strong influence of fashions in scientific thought continues to play an inhibitory role in scientific progress, even in the molecular genetics of cancer, the subject of this Symposium. As an example, we discuss here genes that are altered in expression in cancer cells compared with normal, but are not themselves mutated. As we show here, such genes are plentiful in cancer. Thus, they merit a sharpened focus: to wit, RNA genetics.
From a historical perspective, the genetic basis of cancer was still being hotly debated when I (R.S.) applied for a grant entitled “Genetic Analysis of Tumorigenesis” with a start date in 1978. It was necessary to provide a detailed justification for research on this theme including the clonal origin of cancer, correlations between cancer and chromosome aberrations, the tumorigenic effects of radiation and chemical mutagens, the integration of viral nucleic acids into the genome of virally transformed cells,...
