The Interplay between Nonhomologous End-joining and Cell Cycle Checkpoint Factors in Development, Genomic Stability, and Tumorigenesis
This extract was created in the absence of an abstract.
Excerpt
When one strand of the DNA double helix is broken orotherwise modified, potentially deleterious mutations canbe passed on to one of two daughter cells after semiconservative replication. However, if both strands are brokenat the same or nearby sites, a double-strand break (DSB)occurs. If left unrepaired, chromosomal loss or gain canlead to a marked change in gene dosage, often with important biological consequences for cell progeny. In addition, if a DSB is misrepaired through promiscuous interaction with another chromosome, a translocation mayresult. Although these can be harmless if the event is balanced and the breakpoints are not in coding regions, theyalso can lead to dysregulation of cell functions throughrearrangement of important genes...
