Multiple centrosomes: together they stand, divided they fall

  1. Fanni Gergely1,4 and
  2. Renata Basto2,3
  1. 1 Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Department of Oncology, University of Cambridge, Cambridge CB2 0RE, United Kingdom;
  2. 2 UMR 144, CNRS, Institut Curie, Paris Cedex 05, France

Abstract

Cells with extra centrosomes rely entirely on centrosome clustering mechanisms to assemble a bipolar spindle and to divide in a bipolar fashion. To identify the pathways involved in suppression of multipolarity, Kwon, Godinho, and colleagues (pp. 2189–2203) have set up a genome-wide screen in Drosophila S2 cells. Surprisingly, they found that efficient clustering requires a large number of proteins associated with a variety of cellular functions.

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Related Article

  • RESEARCH PAPER: Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
    • Mijung Kwon,
    • Susana A. Godinho,
    • Namrata S. Chandhok,
    • Neil J. Ganem,
    • Ammar Azioune,
    • Manuel Thery,
    • and David Pellman
    Genes Dev. August 15, 2008 22: 2189-2203; Published in Advance July 28, 2008, doi:10.1101/gad.1700908
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  1. doi: 10.1101/gad.1715208 Genes & Dev. 22: 2291-2296 Copyright © 2008, Cold Spring Harbor Laboratory Press

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