Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis
Abstract
During early mammalian embryogenesis, the genome undergoes global epigenetic reprogramming, losing most of its methylation before re-establishing it de novo at implantation. However, faithful maintenance of methylation at imprinted genes during this process is vital for embryonic development, but the DNA methyltransferase responsible for this maintenance has remained unknown. In this issue of Genes & Development, Hirasawa and colleagues (pp. 1607–1616) show that Dnmt1, and not Dnmt3a or Dnmt3b, maintains methylation at genomic imprints during preimplantation development.
Keywords
Footnotes
-
↵1 Corresponding author.
↵1 E-MAIL wolf.reik{at}bbsrc.ac.uk; FAX 44 1223 496015.
-
Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1690508.
- Copyright © 2008, Cold Spring Harbor Laboratory Press
