A systems view of mRNP biology

  1. Haley Hieronymus and
  2. Pamela A. Silver1
  1. Department of Systems Biology, Harvard Medical School and the Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA

Abstract

Gene expression occurs through a complex mRNA-protein (mRNP) system that stretches from transcription to translation. Gene expression processes are increasingly studied from global perspectives in order to understand their pathways, properties, and behaviors as a system. Here we review these beginnings of mRNP systems biology, as they have emerged from recent large-scale investigation of mRNP components, interactions, and dynamics. Such work has begun to lay the foundation for a broader, integrated view of mRNP organization in gene expression.

Keywords

Footnotes

  • Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1256904.

  • ↵1 Corresponding author. E-MAIL Pamela_silver{at}dfci.harvard.edu; FAX (617) 632-5103.

| Table of Contents

This Article

  1. doi: 10.1101/gad.1256904 Genes & Dev. 18: 2845-2860 Cold Spring Harbor Laboratory Press

Article Category

Share

Current Issue

  1. April 1, 2024, 38 (7-8)
  1. Current Issue
  1. Alert me to new issues of G&D

Life Science Alliance