Endoreplication
- 1Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
- 2National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2753
- Correspondence: b.edgar{at}Dkfz-Heidelberg.de; n.zielke{at}DKFZ-heidelberg.de
Abstract
Developmentally programmed polyploidy occurs by at least four different mechanisms, two of which (endoreduplication and endomitosis) involve switching from mitotic cell cycles to endocycles by the selective loss of mitotic cyclin-dependent kinase (CDK) activity and bypassing many of the processes of mitosis. Here we review the mechanisms of endoreplication, focusing on recent results from Drosophila and mice.
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