X-RAY-INDUCED MUTATIONS IN MICE1
This extract was created in the absence of an abstract.
Excerpt
Introduction
The immediate practical purpose of the work reported here was the obtaining of data that would be useful in the estimation of the genetic hazards of ionizing radiation in man. Up to now, evaluations of these dangers have necessarily had to be based largely on information gained from Drosophila.
If we accept the view that there is no threshold dose, or dose below which genetic effects do not occur, then the problem of estimating the hazard resolves itself into two main questions: (a) What is the increase in mutation rate per dose? (b) How great an increase can be tolerated? The second question is extremely complex: it involves the interaction of a large number of biological factors and also necessitates a consideration of human values. One of the important factors is, of course, that presented in the first question. It is this factor, namely, the magnitude of radiation-induced mutation...
Footnotes
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↵2 The author is grateful to Dr. Liane Brauch Russell for extensive participation in the investigation, to Professor H. J. Muller and Professor Sewall Wright for helpful consultation and to Dr. Alexander Hollaender, Dr. Shields Warren and Dr. Max Zelle for their active support. The work was done with the technical assistance of Josephine S. Gower, Gloria J. Jasny, Elizabeth M. Kelly, Mary H. Major and Patricia A. Sarvella.
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↵1 Work performed under Contract W-7405-eng-26 for the Atomic Energy Commission.
