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Vitamin D and drug-metabolising enzymes

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Abstract

Experimental studies on the molecular regulation of human drug metabolism have revealed that vitamin D up-regulates transcription of several key enzymes, such as CYP3A4, through the vitamin D receptor pathway in intestinal and hepatic cells. Recent data suggest that this results in seasonal changes with higher clearance of orally administered drugs during periods with high UV-B radiation and vitamin D levels. Taken together, vitamin D status might contribute to inter- and intraindividual differences in drug metabolism, but the therapeutic impact of these findings remains to be established.

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  1. Both authors contributed equally to this work and share first authorship.

Authors and Affiliations

  1. Karolinska Institutet, Department of Laboratory Medicine, Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden

    Jonatan D. Lindh, Linda Björkhem-Bergman & Erik Eliasson

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  1. Jonatan D. Lindh
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  2. Linda Björkhem-Bergman
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  3. Erik Eliasson
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Correspondence to Erik Eliasson.

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Lindh, J.D., Björkhem-Bergman, L. & Eliasson, E. Vitamin D and drug-metabolising enzymes. Photochem Photobiol Sci 11, 1797–1801 (2012). https://doi.org/10.1039/c2pp25194a

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