Issue 3, 2016
From the journal:

Organic & Biomolecular Chemistry

Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia†

Hua Zhang,‡a   Jia Liu,‡a   Li-She Gan,b   Seema Dalal,c   Maria B. Casserac  and  Jian-Min Yue*a  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China
E-mail: jmyue@simm.ac.cn

b Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China

c Department of Biochemistry and the Virginia Tech Center for Drug Discovery, MC 0308, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA

Abstract

Chemical investigation into the minor constituents of Aphanamixis grandifolia yielded three new diterpenoid dimers, aphadilactones E–G (1–3) featuring a new carbon skeleton. Their structures and absolute configurations were fully established by comprehensive spectroscopic data analysis and ECD calculation. Discovery of another two new dimers (4 and 5) suggested the structure of recently reported aphanamene A to be re-investigated. Compounds 1–5 showed moderate antimalarial activities with low micromolar IC50 values.

Graphical abstract: Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia

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Article information

DOI
https://doi.org/10.1039/C5OB02296G
Article type
Paper
Submitted
08 Nov 2015
Accepted
20 Nov 2015
First published
23 Nov 2015

Org. Biomol. Chem., 2016,14, 957-962

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Antimalarial diterpenoid dimers of a new carbon skeleton from Aphanamixis grandifolia

H. Zhang, J. Liu, L. Gan, S. Dalal, M. B. Cassera and J. Yue, Org. Biomol. Chem., 2016, 14, 957 DOI: 10.1039/C5OB02296G

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