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Visual estimation of the tumor volume in prostate cancer: a useful means for predicting biochemical-free survival after radical prostatectomy?

Prostate Cancer and Prostatic Diseases volume 10, pages 66–71 (2007)Cite this article

Abstract

Absolute and relative (ratio absolute tumor volume to gland volume) tumor volumes were visually estimated in 528 prostatectomy specimens. Surveying a mean post-surgical follow-up of 49 months, both parameters were analyzed regarding their aptitude for prognostication. We found relative tumor volumes exceeding 25% to independently predict biochemical recurrence reflected by post-surgical prostate-specific antigen progression, which was also determined to be increased to 28% when absolute tumor volumes exceeded 10 cm3. However, this cutoff failed to be an independent prognosticator. Because the visual estimation of both parameters can easily be performed, they are felt to be formidable candidates for deriving prognostic information during routine procedures.

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Author notes

  1. M May and S Gunia: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, Carl-Thiem Hospital Cottbus, Cottbus, Germany

    M May

  2. Department of Urology, Vivantes-Clinic Am Urban, Berlin, Germany

    M Siegsmund & F Hammermann

  3. Institute of Pathology, Vivantes-Clinic Am Urban, Berlin, Germany

    V Loy

  4. Institute of Pathology, Carl-Thiem Hospital Cottbus, Cottbus, Germany

    S Gunia

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  1. M May
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  2. M Siegsmund
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  3. F Hammermann
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  4. V Loy
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  5. S Gunia
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Correspondence to S Gunia.

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May, M., Siegsmund, M., Hammermann, F. et al. Visual estimation of the tumor volume in prostate cancer: a useful means for predicting biochemical-free survival after radical prostatectomy?. Prostate Cancer Prostatic Dis 10, 66–71 (2007). https://doi.org/10.1038/sj.pcan.4500928

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