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Analysis of IgH translocations, chromosome 13q14 and 17p13.1(p53) deletions by fluorescence in situ hybridization in Waldenstrom's macroglobulinemia: a single center study of 22 cases

Leukemia volume 18, pages 1160–1162 (2004)Cite this article

A Corrigendum to this article was published on 23 August 2004

TO THE EDITOR

Waldenstrom macroglobulinemia (WM) is a clinical syndrome characterized by a serum IgM paraprotein and a lymphoplasmacytic bone marrow infiltrate.1 Patient may present with organomegaly, anemia, hyperviscosity, cryoglobulinemia, amyloidosis and autoimmune disease. While WM has clinical and pathological features resembling multiple myeloma (MM) or chronic lymphocytic leukemia (CLL), little is known about its pathogenesis. We and others have recently shown that translocations involving immunoglobulin heavy-chain gene (IgH) and deletions of chromosome 13q14 are the most common and prognostic significant genetic changes in MM with a frequency up to 75 and 50%, respectively.2,3,4 Deletions of 13q14 are also the most frequent genomic aberration in CLL with a frequency of 55%.5 Deletions of the p53 tumor suppressor gene at locus 17p13.1 are found in 7% of patients with CLL5 and 10% of patients with MM.3 As the data on these molecular cytogenetic changes in WM are limited, we used cytoplasmic IgM fluorescence combined with interphase fluorescence in situ hybridization (cIg-FISH) to evaluate these genomic aberrations in 22 patients with WM.

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Authors and Affiliations

  1. Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada

    H Chang, D Li & B Patterson

  2. Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada

    S Samiee, C I Chen & A Keith Stewart

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  1. H Chang
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  2. S Samiee
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Correspondence to H Chang.

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Chang, H., Samiee, S., Li, D. et al. Analysis of IgH translocations, chromosome 13q14 and 17p13.1(p53) deletions by fluorescence in situ hybridization in Waldenstrom's macroglobulinemia: a single center study of 22 cases. Leukemia 18, 1160–1162 (2004). https://doi.org/10.1038/sj.leu.2403369

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