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Body weight and weight change in relation to blood pressure in normotensive men

Journal of Human Hypertension volume 21, pages 45–52 (2007)Cite this article

Abstract

We examined blood pressure (BP) in association with weight change since age 20, body mass index (BMI) at different ages and fat distribution in normotensive individuals using baseline survey data collected in the Shanghai Men's Health Study, an ongoing population-based prospective cohort study of Chinese men aged 40–74 years. All anthropometric and BP measurements were performed by medical professionals. Included in this analysis were 25 619 men who had no prior history of hypertension, diabetes or cardiovascular disease, never took any antihypertensive medication and had both normal systolic BP (SBP) and diastolic BP (DBP) (<140/90 mm Hg). Both SBP and DBP increased linearly across the whole range of weight gain since age 20. The adjusted mean differences between the highest and the lowest quintiles of weight gain were 6.0 mm Hg (95% confidence interval (CI): 5.6, 6.5) for SBP and 3.9 (95% CI: 3.6, 4.2) for DBP. When accounting for BMI at age 20, the multivariate-adjusted odds ratio of prehypertension (SBP, 120–139 and/or DBP, 80–89 mm Hg) was 4.1 (95% CI: 3.7, 4.5; P for trend <0.0001) comparing the extreme quintiles of weight gain. Similar positive associations were also observed for BMI at age 40, current BMI, circumferences of the waist and hips and waist-to-hip ratio. In conclusion, these data suggest that weight gain since age 20 and elevated adiposity may contribute significantly to the rise in BP in normotensive individuals, emphasizing the importance of weight control throughout adulthood in preventing high BP.

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References

  1. Stevenson DR . Blood pressure and age in cross-cultural perspective. Hum Biol 1999; 71: 529–551.

    CAS  PubMed  Google Scholar 

  2. Vokonas PS, Kannel WB, Cupples LA . Epidemiology and risk of hypertension in the elderly: the Framingham Study. J Hypertens Suppl 1988; 6: S3–S9.

    CAS  PubMed  Google Scholar 

  3. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M et al. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988–1991. Hypertension 1995; 25: 305–313.

    Article  CAS  Google Scholar 

  4. Poirier P, Lemieux I, Mauriege P, Dewailly E, Blanchet C, Bergeron J et al. Impact of waist circumference on the relationship between blood pressure and insulin: the Quebec Health Survey. Hypertension 2005; 45: 363–367.

    Article  CAS  Google Scholar 

  5. Benetou V, Bamia C, Trichopoulos D, Mountokalakis T, Psaltopoulou T, Trichopoulou A . The association of body mass index and waist circumference with blood pressure depends on age and gender: a study of 10 928 non-smoking adults in the Greek EPIC cohort. Eur J Epidemiol 2004; 19: 803–809.

    Article  Google Scholar 

  6. Siani A, Cappuccio FP, Barba G, Trevisan M, Farinaro E, Lacone R et al. The relationship of waist circumference to blood pressure: the Olivetti Heart Study. Am J Hypertens 2002; 15: 780–786.

    Article  Google Scholar 

  7. Treatment of Mild Hypertension Research Group. The treatment of mild hypertension study: a randomized, placebo-controlled trial of a nutritional-hygienic regimen along with various drug monotherapies. Arch Intern Med 1991; 151: 1413–1423.

  8. Reisin E, Abel R, Modan M, Silverberg DS, Eliahou HE, Modan B . Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N Engl J Med 1978; 298: 1–6.

    Article  CAS  Google Scholar 

  9. Davis BR, Blaufox MD, Oberman A, Wassertheil-Smoller S, Zimbaldi N, Cutler JA et al. Reduction in long-term antihypertensive medication requirements. Effects of weight reduction by dietary intervention in overweight persons with mild hypertension. Arch Intern Med 1993; 153: 1773–1782.

    Article  CAS  Google Scholar 

  10. Trials of Hypertension Prevention Collaborative Research Group. Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure: the Trials of Hypertension Prevention, phase II. Arch Intern Med 1997; 157: 657–667.

  11. Stamler R, Stamler J, Gosch FC, Civinelli J, Fishman J, McKeever P et al. Primary prevention of hypertension by nutritional–hygienic means. Final report of a randomized, controlled trial. JAMA 1989; 262: 1801–1807.

    Article  CAS  Google Scholar 

  12. Moore LL, Visioni AJ, Qureshi MM, Bradlee ML, Ellison RC, D'Agostino R . Weight loss in overweight adults and the long-term risk of hypertension: the Framingham study. Arch Intern Med 2005; 165: 1298–1303.

    Article  Google Scholar 

  13. Huang Z, Willett WC, Manson JE, Rosner B, Stampfer MJ, Speizer FE et al. Body weight, weight change, and risk for hypertension in women. Ann Intern Med 1998; 128: 81–88.

    Article  CAS  Google Scholar 

  14. Kannel WB, Garrison RJ, Dannenberg AL . Secular blood pressure trends in normotensive persons: the Framingham Study. Am Heart J 1993; 125: 1154–1158.

    Article  CAS  Google Scholar 

  15. He J, Klag MJ, Whelton PK, Chen JY, Qian MC, He GQ . Body mass and blood pressure in a lean population in Southwestern China. Am J Epidemiol 1994; 139: 380–389.

    Article  CAS  Google Scholar 

  16. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL et al. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206–1252.

    Article  CAS  Google Scholar 

  17. Zhang X, Shu XO, Gao YT, Yang G, Matthews CE, Li Q et al. Anthropometric predictors of coronary heart disease in Chinese women. Int J Obes Relat Metab Disord 2004; 28: 734–740.

    Article  CAS  Google Scholar 

  18. Perloff D, Grim C, Flack J, Frohlich ED, Hill M, McDonald M et al. Human blood pressure determination by sphygmomanometry. Circulation 1993; 88: 2460–2470.

    Article  CAS  Google Scholar 

  19. Cleveland WS, Devlin SJ, Grosse E . Regression by local fitting. J Econ 1988; 37: 87–114.

    Article  Google Scholar 

  20. SAS Institute Inc. SAS/STAT User's Guide, version 8. SAS Institute Inc.: Cary, NC, 1999.

  21. Stamler R, Stamler J, Riedlinger WF, Algera G, Roberts RH . Weight and blood pressure: findings in hypertension screening of 1 million Americans. JAMA 1978; 240: 1607–1610.

    Article  CAS  Google Scholar 

  22. Brown CD, Higgins M, Donato KA, Rohde FC, Garrison R, Obarzanek E et al. Body mass index and the prevalence of hypertension and dyslipidemia. Obes Res 2000; 8: 605–619.

    Article  CAS  Google Scholar 

  23. Colin Bell A, Adair LS, Popkin BM . Ethnic differences in the association between body mass index and hypertension. Am J Epidemiol 2002; 155: 346–353.

    Article  CAS  Google Scholar 

  24. Field AE, Coakley EH, Must A, Spadano JL, Laird N, Dietz WH et al. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 2001; 161: 1581–1586.

    Article  CAS  Google Scholar 

  25. Elmer PJ, Grimm Jr R, Laing B, Grandits G, Svendsen K, Van Heel N et al. Lifestyle intervention: results of the Treatment of Mild Hypertension Study (TOMHS). Prev Med 1995; 24: 378–388.

    Article  CAS  Google Scholar 

  26. Whelton PK, Appel LJ, Espeland MA, Applegate WB, Ettinger Jr WH, Kostis JB et al. Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group. JAMA 1998; 279: 839–846.

    Article  CAS  Google Scholar 

  27. Stevens VJ, Obarzanek E, Cook NR, Lee IM, Appel LJ, Smith West D, et al., Trials for the Hypertension Prevention Research Group. Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, phase II. Ann Intern Med 2001; 134: 1–11.

    Article  CAS  Google Scholar 

  28. Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM . Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension 2003; 42: 878–884.

    Article  CAS  Google Scholar 

  29. Eckel RH, Grundy SM, Zimmet PZ . The metabolic syndrome. Lancet 2005; 365: 1415–1428.

    Article  CAS  Google Scholar 

  30. Julius S, Valentini M, Palatini P . Overweight and hypertension: a 2-way street? Hypertension 2000; 35: 807–813.

    Article  CAS  Google Scholar 

  31. Esler M, Rumantir M, Wiesner G, Kaye D, Hastings J, Lambert G . Sympathetic nervous system and insulin resistance: from obesity to diabetes. Am J Hypertens 2001; 14: 304S–309S.

    Article  CAS  Google Scholar 

  32. Hall JE, Hildebrandt DA, Kuo J . Obesity hypertension: role of leptin and sympathetic nervous system. Am J Hypertens 2001; 14: 103S–115S.

    Article  CAS  Google Scholar 

  33. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al., American Heart Association; Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006; 113: 898–918.

    Article  Google Scholar 

  34. Verdecchia P, Angeli F . Natural history of hypertension subtypes. Circulation 2005; 111: 1094–1096.

    Article  Google Scholar 

  35. Pauletto P, Rattazzi M . Inflammation and hypertension: the search for a link. Nephrol Dial Transplant 2006; 21: 850–853.

    Article  Google Scholar 

  36. Willett WC . Nutritional Epidemiology, 2nd edn. Oxford University Press: New York, 1998.

    Book  Google Scholar 

  37. Stewart AL . The reliability and validity of self-reported weight and height. J Chronic Dis 1982; 35: 295–309.

    Article  CAS  Google Scholar 

  38. Miura K, Dyer AR, Greenland P, Daviglus ML, Hill M, Liu K, et al., Chicago Heart Association. Pulse pressure compared with other blood pressure indexes in the prediction of 25-year cardiovascular and all-cause mortality rates: The Chicago Heart Association Detection Project in Industry Study. Hypertension 2001; 38: 232–237.

    Article  CAS  Google Scholar 

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Acknowledgements

We are grateful to the participants and research staff of the Shanghai Men's Health Study for their contribution to the study. This work was supported partially by USPHS Grant RO1CA82729.

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Authors and Affiliations

  1. Department of Medicine, Vanderbilt University School of Medicine, Center for Health Services Research, Vanderbilt University Medical Center, Nashville, TN, USA

    G Yang, W Zheng, X Zhang & X-O Shu

  2. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

    Y-B Xiang, W-H Xu & H-L Li

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  1. G Yang
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Correspondence to G Yang.

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Yang, G., Xiang, YB., Zheng, W. et al. Body weight and weight change in relation to blood pressure in normotensive men. J Hum Hypertens 21, 45–52 (2007). https://doi.org/10.1038/sj.jhh.1002099

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