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Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects

Journal of Human Hypertension volume 19, pages 907–913 (2005)Cite this article

Abstract

The relationships between C-reactive protein (CRP), uric acid (UA), glomerular filtration rate (GFR), and arterial stiffness have not been fully investigated. The aim of this study was to clarify whether CRP, UA, and estimated GFR are related to arterial stiffness estimated using brachial-ankle pulse wave velocity (baPWV). The subjects were local government employees (3412 men and 854 women). baPWV, CRP, UA, GFR, and conventional risk factors were evaluated. Multiple linear regression analyses revealed that CRP and UA were significantly related to an elevation of PWV in male and female subjects, and that the estimated GFR was significantly related to an elevation of PWV in male subjects. Significant progressive increases in baPWV were observed across the quartiles of CRP in male subjects and for UA in male and female subjects. In female subjects, the relationship of quartile CRP to baPWV had marginal significance (P=0.055). But, in male and female subjects, quartile of estimated GFR had no significant association with PWV. These results suggest that CRP and UA are associated with an increase of arterial stiffness in male and female subjects, and that estimated GFR is possibly related to arterial stiffness in male subjects.

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Acknowledgements

This work was supported in part by a Grant-in-Aid for Young Scientists from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a Grant-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare of Japan.

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Authors and Affiliations

  1. Department of Public Heath, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Y Saijo, M Utsugi, E Yoshioka, N Horikawa, T Sato, Y Y Gong & R Kishi

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  1. Y Saijo
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  2. M Utsugi
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  3. E Yoshioka
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  4. N Horikawa
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Correspondence to Y Saijo.

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Saijo, Y., Utsugi, M., Yoshioka, E. et al. Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects. J Hum Hypertens 19, 907–913 (2005). https://doi.org/10.1038/sj.jhh.1001913

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