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Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31–q33

Genes & Immunity volume 4, pages 265–268 (2003)Cite this article

Abstract

We have previously mapped a locus controlling Plasmodium falciparum blood infection levels (PFBI) to chromosome 5q31–q33. We genotyped 19 microsatellite markers on chromosome 5q31–q33 in a new sample of 44 pedigrees comprising 84 nuclear families and 292 individuals living in a P. falciparum endemic area. Using a nonparametric multipoint variance-component approach (by GENEHUNTER), we evidenced a peak of linkage close to D5S636 (P=0.0069), with a heritability of 0.46. Using a variance-component method for linkage-disequilibrium mapping of quantitative traits (by QTDT) and the Bonferroni correction for multiple testing, we further detected allelic association in the presence of linkage between blood infection levels and D5S487 (P=6 × 10−5; Pc=0.0011), which is located on the distal part of the peak. These results confirm the importance of chromosome 5q31–q33 in the genetic control of PFBI levels.

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Acknowledgements

This research was supported by the French Ministry of Research and Technology, the Fondation pour la Recherche Médicale (France), the Conseil Régional Provence Alpes Côte d'Azur (France), and the Conseil Général des Bouches du Rhône (France). BK and CA were, respectively, supported by studentships from the Agence Universitaire de la Francophonie and the Fondation pour la Recherche Médicale. LF is supported by a studentship from the French Ministry of Research and Technology.

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Author notes

  1. L Flori and B Kumulungui: Both authors equally contributed to this work.

Authors and Affiliations

  1. Université de la Méditerranée, Marseille, France

    L Flori, C Aucan, C Esnault, F Fumoux & P Rihet

  2. Université de Ouagadougou, Burkina Faso

    B Kumulungui & A S Traoré

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  1. L Flori
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  2. B Kumulungui
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  3. C Aucan
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  5. A S Traoré
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  6. F Fumoux
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  7. P Rihet
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Correspondence to P Rihet.

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Flori, L., Kumulungui, B., Aucan, C. et al. Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31–q33. Genes Immun 4, 265–268 (2003). https://doi.org/10.1038/sj.gene.6363960

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