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The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

Nature Structural Biology volume 3, pages 747–752 (1996)Cite this article

The granulin/epithelin protein motif has an unusual structure consisting of a parallel stack of β-hairpins stapled together by six disulphide bonds. The new structure also contains a folding subdomain shared by small toxins, protease inhibitors as well as the EGF-like protein modules.

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Authors and Affiliations

  1. Biotechnology Research Institute and the Montréal Joint Centre for Structural Biology, National Research Council of Canada, 6100 Royalmount Avenue, Montréal, Québec, Canada, H4P 2R2

    Richard Hrabal, Zhigang Chen & Feng Ni

  2. Endocrine Laboratory, Royal Victoria Hospital and Department of Medicine, McGill University, Montréal, Québec, Canada, H3A1A1

    Susan James & Hugh P.J. Bennett

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  1. Richard Hrabal
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  2. Zhigang Chen
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  3. Susan James
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Hrabal, R., Chen, Z., James, S. et al. The hairpin stack fold, a novel protein architecture for a new family of protein growth factors. Nat Struct Mol Biol 3, 747–752 (1996). https://doi.org/10.1038/nsb0996-747

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