New data suggest that the first 2 years of treatment for giant-cell arteritis carry substantial risks, including myocardial infarction and death. Will these findings have implications for clinical practice?
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Survival and death causes of patients with giant cell arteritis in Western Norway 1972–2012: a retrospective cohort study
Arthritis Research & Therapy Open Access 25 June 2019
-
Incidence of giant cell arteritis in Western Norway 1972–2012: a retrospective cohort study
Arthritis Research & Therapy Open Access 15 December 2017
-
The Sphinx’s riddle: cardiovascular involvement in autoimmune rheumatic disease
BMC Cardiovascular Disorders Open Access 28 October 2016
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tomasson, G. et al. Risk for cardiovascular disease early and late after a diagnosis of giant-cell arteritis. Ann. Intern. Med. 160, 73–80 (2014).
Mohammad, A. J., Nilsson, J. A., Jacobsson, L. T., Merkel, P. A. & Turesson, C. Incidence and mortality rates of biopsy-proven giant cell arteritis in southern Sweden. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-204652.
Smeeth, L., Cook, C. & Hall, A. J. Incidence of diagnosed polymyalgia rheumatica and temporal arteritis in the United Kingdom, 1990–2001. Ann. Rheum. Dis. 65, 1093–1098 (2006).
Brack, A., Martinez-Taboada, V., Stanson, A., Goronzy, J. J. & Weyand, C. M. Disease pattern in cranial and large-vessel giant-cell arteritis. Arthritis Rheum. 42, 311–317 (1999).
Deng, J., Younge, B. R., Olshen, R. A., Goronzy, J. J. & Weyand, C. M. TH17 and TH1 T-cell responses in giant cell arteritis. Circulation 121, 906–915 (2010).
Nadkarni, S. et al. Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression. Circ. Res. 114, 242–248 (2014).
Hancock, A. T., Mallen, C. D., Belcher, J. & Hider, S. L. Association between polymyalgia rheumatica and vascular disease: a systematic review. Arthritis Care Res. (Hoboken) 64, 1301–1305 (2012).
Espitia, O. et al. Giant cell arteritis with or without aortitis at diagnosis. A retrospective study of 22 patients with longterm followup. J. Rheumatol. 39, 2157–2162 (2012).
Ninan J. et al. Mortality in patients with biopsy-proven giant cell arteritis: a South Australian population-based study. J. Rheumatol. 38, 2215–2217 (2011).
Unizony, S., Stone, J. H. & Stone, J. R. New treatment strategies in large vessel vasculitis. Curr. Opin. Rheumatol. 25, 3–9 (2013).
Acknowledgements
B.D. acknowledges support from Southend University Hospital R&D Department and Essex & Hertfordshire CLRN. S.L.M. is funded by an NIHR Clinical Scientist fellowship. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
B.D. has received honoraria for clinical trial design advisory boards from Merck, Mundipharma, Roche, Servier and Sobi. S.L.M. has received funding from Pfizer and Napp to attend conferences.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Mackie, S., Dasgupta, B. Dealing with increased vascular risk and mortality in GCA. Nat Rev Rheumatol 10, 264–265 (2014). https://doi.org/10.1038/nrrheum.2014.38
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrrheum.2014.38
This article is cited by
-
Survival and death causes of patients with giant cell arteritis in Western Norway 1972–2012: a retrospective cohort study
Arthritis Research & Therapy (2019)
-
Incidence of giant cell arteritis in Western Norway 1972–2012: a retrospective cohort study
Arthritis Research & Therapy (2017)
-
The Sphinx’s riddle: cardiovascular involvement in autoimmune rheumatic disease
BMC Cardiovascular Disorders (2016)