Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Transplantation

Outcomes of prenatal immunosuppression

Nature Reviews Nephrology volume 11, pages 390–391 (2015)Cite this article

Subjects

A new study reports abnormal peripheral lymphocyte counts and an increased incidence of hospital admission for infections among infants born to mothers with kidney transplants. Further studies are required to investigate the effects of in utero exposure to immunosuppressive agents on immune system development and long-term disease risk in this population.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Deshpande, N. A. et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am. J. Transplant. 11, 2388–2404 (2011).

    Article  CAS  Google Scholar 

  2. Ono, E. et al. Immunophenotypic profile and increased risk of hospital admission for infection in infants born to female kidney transplant recipients. Am. J. Transplant. http://dx.doi.org/10.1111/ajt.13143.

  3. Di Paolo, S. et al. Immunologic evaluation during the first year of life of infants born to cyclosporine-treated female kidney transplant recipients: analysis of lymphocyte subpopulations and immunoglobulin serum levels. Transplantation 69, 2049–2054 (2000).

    Article  CAS  Google Scholar 

  4. Takahashi, N., Nishida, H. & Hoshi, J. Severe B cell depletion in newborns from renal transplant mothers taking immunosuppressive agents. Transplantation 57, 1617–1621 (1994).

    Article  CAS  Google Scholar 

  5. Kihara, Y. et al. Comparative study of the cellular pharmacodynamics of calcineurin inhibitors between patients with chronic renal failure awaiting renal transplantation and cirrhosis patients awaiting liver transplantation. Cell Transplant. 18, 639–646 (2009).

    Article  Google Scholar 

  6. Schönbeck, U. & Libby, P. The CD4/CD154 receptor/ligand dyad. Cell Mol. Life Sci. 58, 4–43 (2001).

    Article  Google Scholar 

  7. Martino, D. et al. Epigenetics in immune development and in allergic and autoimmune diseases. J. Reprod. Immunol. 104–105, 43–48 (2014).

    Article  Google Scholar 

Download references

Acknowledgements

R.H.M.'s work is supported by NIH grants U01 DK-03012 and R24HD050837. H.M.H.'s work is supported by NIH grants R43 AR065817, PO1 CA177322, R01 HL086324, R01 AR064755 and R01 AI107779.

Author information

Authors and Affiliations

  1. Division of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093-0630, CA, USA

    Robert H. Mak

  2. Division of Allergy, Immunology and Rheumatology, Rady Children's Hospital, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093-0630, CA, USA

    Hal M. Hoffman

Authors
  1. Robert H. Mak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hal M. Hoffman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert H. Mak.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mak, R., Hoffman, H. Outcomes of prenatal immunosuppression. Nat Rev Nephrol 11, 390–391 (2015). https://doi.org/10.1038/nrneph.2015.78

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2015.78

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing