Many experts maintain that GERD is caused by dysfunction of the gastroesophageal barrier and that gastric acid secretion is not the primary underlying defect. By contrast, a recent study by Reimer and colleagues raises the possibility that increased gastric acid secretion is an important cause of GERD.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Reimer, C., Søndergaard, B., Hilsted, L. & Bytzer, P. Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy. Gastroenterology 137, 80–87 (2009).
McColl, K. E. & Gillen, D. Evidence that proton-pump inhibitor therapy induces the symptoms it is used to treat. Gastroenterology 137, 20–22 (2009).
Gillen, D., Wirz, A. A., Ardill, J. E. & McColl, K. E. Rebound hypersecretion after omeprazole and its relation to on-treatment acid suppression and Helicobacter pylori status. Gastroenterology 116, 239–247 (1999).
Gillen, D., Wirz, A. A. & McColl, K. E. Helicobacter pylori eradication releases prolonged increased acid secretion following omeprazole treatment. Gastroenterology 126, 980–988 (2004).
Hirschowitz, B. I. A critical analysis, with appropriate controls, of gastric acid and pepsin secretion in clinical esophagitis. Gastroenterology 101, 1149–1158 (1991).
Collen, M. J., Lewis, J. H. & Benjamin, S. B. Gastric acid hypersecretion in refractory gastroesophageal reflux disease. Gastroenterology 98, 654–661 (1990).
Collen, M. J. & Johnson, D. A. Correlation between basal acid output and daily ranitidine dose required for therapy in Barrett's esophagus. Dig. Dis. Sci. 37, 570–576 (1992).
Johansson, K. E., Ask, P., Boeryd, B., Fransson, S. G. & Tibbling, L. Oesophagitis, signs of reflux, and gastric acid secretion in patients with symptoms of gastro-oesophageal reflux disease. Scand. J. Gastroenterol. 21, 837–847 (1986).
Gardner, J. D., Sloan, S., Miner, P. B. Jr & Robinson, M. Meal-stimulated gastric acid secretion and integrated gastric acidity in gastro-oesophageal reflux disease. Aliment. Pharmacol. Ther. 17, 945–953 (2003).
Hunfeld, N. G., Geus, W. P. & Kuipers, E. J. Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors. Aliment. Pharmacol. Ther. 25, 39–46 (2007).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author is President of Science for Organizations Inc., a company that provides consulting services to pharmaceutical and biotechnology companies.
Rights and permissions
About this article
Cite this article
Gardner, J. Increased gastric acid secretion as a possible cause of GERD. Nat Rev Gastroenterol Hepatol 7, 125–126 (2010). https://doi.org/10.1038/nrgastro.2009.240
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2009.240
This article is cited by
-
Breakfast skipping and prevalence of heartburn syndrome among Iranian adults
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity (2020)
-
Time series analysis of gastric acid secretion over a 20-year period in normal Japanese men
Journal of Gastroenterology (2015)