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Heart failure

Central sleep apnoea in HF—what can we learn from SERVE-HF?

Nature Reviews Cardiology volume 12, pages 686–687 (2015)Cite this article

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The results of the first randomized, controlled trial to assess adaptive servo-ventilation (ASV) for central sleep apnoea were expected to confirm the positive findings from previous observational studies and meta-analyses. However, ASV did not have the expected beneficial effects for patients with heart failure and reduced ejection fraction.

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References

  1. Cowie, M. R. et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N. Engl. J. Med. 373, 1095–1105 (2015).

    Article  CAS  Google Scholar 

  2. Oldenburg, O. et al. Sleep-disordered breathing in patients with symptomatic heart failure: awcontemporary study of prevalence in and characteristics of 700 patients. Eur. J. Heart Fail. 9, 251–257 (2007).

    Article  Google Scholar 

  3. Bradley, T. D. et al. Continuous positive airway pressure for central sleep apnea and heart failure. N. Engl. J. Med. 353, 2025–2033 (2005).

    Article  CAS  Google Scholar 

  4. Arzt, M. et al. Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). Circulation 115, 3173–3180 (2007).

    Article  Google Scholar 

  5. Teschler, H. et al. Adaptive pressure support servo-ventilation: a novel treatment for Cheyne-Stokes respiration in heart failure. Am. J. Respir. Crit. Care Med. 164, 614–619 (2001).

    Article  CAS  Google Scholar 

  6. Oldenburg, O. et al. Adaptive servoventilation improves cardiac function and respiratory stability. Clin. Res. Cardiol. 100, 107–115 (2011).

    Article  Google Scholar 

  7. Corra, U. et al. Sleep and exertional periodic breathing in chronic heart failure: prognostic importance and interdependence. Circulation 113, 44–50 (2006).

    Article  Google Scholar 

  8. Bradley, T. D. et al. Sleep apnea and heart failure: Part II: central sleep apnea. Circulation 107, 1822–1826 (2003).

    Article  Google Scholar 

  9. Wedewardt, J. et al. Cheyne-Stokes respiration in heart failure: cycle length is dependent on left ventricular ejection fraction. Sleep Med. 11, 137–142 (2010).

    Article  Google Scholar 

  10. Oldenburg, O. et al. Nocturnal hypoxemic burden: time of hypoxemia represents a robust and independent predictor of death in chronic heart failure and reduced ejection fraction [abstract]. Eur. Heart J. 36 (Suppl.), 1198 (2015).

    Google Scholar 

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Acknowledgements

We thank Ms Nicola Ryan for language editing assistance.

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Authors and Affiliations

  1. Clinic for Cardiology, Herz-und Diabeteszentrum NRW, Ruhr-University Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany

    Olaf Oldenburg & Dieter Horstkotte

Authors
  1. Olaf Oldenburg
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  2. Dieter Horstkotte
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Corresponding author

Correspondence to Olaf Oldenburg.

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Competing interests

O.O. has received research support from ResMed Inc., Respicardia Inc., and Sorin Group. D.H. declares no competing interests.

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Oldenburg, O., Horstkotte, D. Central sleep apnoea in HF—what can we learn from SERVE-HF?. Nat Rev Cardiol 12, 686–687 (2015). https://doi.org/10.1038/nrcardio.2015.168

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