Abstract
Understanding the complexity of cancer depends on an elucidation of the underlying regulatory networks, at the cellular and intercellular levels and in their temporal dimension. This Opinion article focuses on the multilevel crosstalk between the Notch pathway and the p53 and p63 pathways. These two coordinated signalling modules are at the interface of external damaging signals and control of stem cell potential and differentiation. Positive or negative reciprocal regulation of the two pathways can vary with cell type and cancer stage. Therefore, selective or combined targeting of the two pathways could improve the efficacy and reduce the toxicity of cancer therapies.
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Acknowledgements
I thank C. Brisken and C. Missero for careful reading of the manuscript and J. Aster and I. Screpanti for useful feedback. I apologize to authors whose work was not directly quoted owing to space limitations and the complexity involved. This work was supported by US National Institutes of Health grants AR054856 and AR39190 the Swiss National Foundation and a grant from the European Union (Epistem, Sixth Framework Programme, LSHB-CT-2005-019067).
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Dotto, G. Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer 9, 587–595 (2009). https://doi.org/10.1038/nrc2675
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DOI: https://doi.org/10.1038/nrc2675
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