Increasing rates of obesity and obesity-associated type 2 diabetes are threatening to reverse recent gains in reducing the rates of cardiovascular and thrombotic disease. A new study in obese mice shows that tissue factor, the principal initiator of coagulation, is also promoting the development of insulin resistance and obesity (pages 1490–1497).
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Zhang, N., Lawrence, D. Tissue factor and obesity, a two-way street. Nat Med 17, 1343–1344 (2011). https://doi.org/10.1038/nm.2551
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DOI: https://doi.org/10.1038/nm.2551