Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Glucocorticoid therapy in rheumatoid arthritis: intra-articular injections versus systemic administration

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Jahangier ZN et al. (2005) Is radiation synovectomy for arthritis of the knee more effective than intraarticular treatment with glucocorticoids? Results of an eighteen-month randomized, double-blind, placebo controlled crossover trial. Arthritis Rheum 52: 3391–3402

    Article  CAS  Google Scholar 

  2. af Klint E et al. (2005) Intraaarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels. Arthritis Rheum 52: 3880–3889

    Article  CAS  Google Scholar 

  3. Kirwan JR et al. (1995) The effect of glucocorticoids on joint destruction in rheumatoid arthritis. N Engl J Med 333: 142–146

    Article  CAS  Google Scholar 

  4. Goekoop-Ruiterman YPM et al. (2005) Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum 52: 3381–3390

    Article  CAS  Google Scholar 

  5. Boers M et al. (1997) Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis. Lancet 350: 309–318

    Article  CAS  Google Scholar 

  6. Wassenberg S et al. (2005) Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 52: 3371–3380

    Article  CAS  Google Scholar 

  7. Svensson B et al. (2005) Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial. Arthritis Rheum 52: 3360–3370

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The synopsis was written by Jasmine Farsarakis, Associate Editor, Nature Clinical Practice.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Edward D Harris Jr.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harris, E. Glucocorticoid therapy in rheumatoid arthritis: intra-articular injections versus systemic administration. Nat Rev Rheumatol 2, 184–185 (2006). https://doi.org/10.1038/ncprheum0160

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncprheum0160

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing