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References
Kang Y et al. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3: 537–549
Minn AJ et al. (2005) Genes that mediate breast cancer metastasis to lung. Nature 436: 518–524
Pantel K and Brakenhoff R (2004) Dissecting the metastatic cascade. Nat Rev Cancer 4: 448–456
Braun S et al. (2005) A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 353: 793–802
Meng S et al. (2004) Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res 10: 8152–8162
Solakoglu O et al. (2002) Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors. Proc Natl Acad Sci USA 99: 2246–2251
Alix-Panabières C et al. : Detection and characterization of putative metastatic precursor cells in cancer patients. Clin Chem, in press
Gudjonsson T et al. (2002) Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev 16: 693–706
Zach O and Lutz D (2006) Tumor cell detection in peripheral blood and bone marrow. Curr Opin Oncol 18: 48–56
Cristofanilli M et al. (2004) Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351: 781–791
Cristofanilli M and Mendelsohn J (2006) Circulating tumor cells in breast cancer: advanced tools for “tailored” therapy? Proc Natl Acad Sci USA 103: 17073–17074
Acknowledgements
The authors would like to acknowledge grant support from the European Commission (DISMALproject, contract No. LSHCCT- 2005-018911), Deutsche Forschungsgemeinschaft (PA341/15-2), and Deutsche Krebshilfe (10-2181-Pa2). Competing interests
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K Pantel has received a research grant from Veridex, USA (the distributor of the CellSearch™ system). C Alix-Panabières declared she has no competing interests.
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Pantel, K., Alix-Panabières, C. The clinical significance of circulating tumor cells. Nat Rev Clin Oncol 4, 62–63 (2007). https://doi.org/10.1038/ncponc0737
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DOI: https://doi.org/10.1038/ncponc0737
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