How different integrin receptors for the same extracellular ligand transduce distinct cellular responses is unclear. The characterization of the class-specific adhesomes of β1 and αV integrins now shows that whereas αV integrins promote unbranched actin polymerization, β1 integrins induce myosin-II-dependent contractility, and both integrin subtypes synergistically mediate rigidity sensing.
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Zaidel-Bar, R. Job-splitting among integrins. Nat Cell Biol 15, 575–577 (2013). https://doi.org/10.1038/ncb2770
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DOI: https://doi.org/10.1038/ncb2770
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