Genotoxic stress induces a survival response by releasing the transcription factor NF-κB from its inhibitor IκBα. In response to DNA damage, this initially requires the nuclear modification of the IκB kinase regulator NEMO/IKKγ by SUMO and ubiquitin.
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Hay, R. Modifiying NEMO. Nat Cell Biol 6, 89–91 (2004). https://doi.org/10.1038/ncb0204-89
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DOI: https://doi.org/10.1038/ncb0204-89
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