This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Concomitant plasmacytoma and B cell lymphoma with discordant light chain expression but clonal identity
Annals of Hematology Open Access 08 March 2012
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Brouet JC, Fermand JP, Laurent G, Grange MJ, Chevalier A, Jacquillat C et al. The association of chronic lymphocytic leukaemia and multiple myeloma: a study of eleven patients. Br J Haematol 1985; 59: 55–66.
Chang H, Wechalekar A, Li L, Reece D . Molecular cytogenetic abnormalities in patients with concurrent chronic lymphocytic leukemia and multiple myeloma shown by interphase fluorescence in situ hybridization: evidence of distinct clonal origin. Cancer Genet Cytogenet 2004; 148: 44–48.
Hoffman KD, Rudders RA . Multiple myeloma and chronic lymphocytic leukemia in a single individual. Arch Intern Med 1977; 137: 232–235.
Saltman DL, Ross JA, Banks RE, Ross FM, Ford AM, Mackie MJ . Molecular evidence for a single clonal origin in biphenotypic concomitant chronic lymphocytic leukemia and multiple myeloma. Blood 1989; 74: 2062–2065.
Shpilberg O, Mark Z, Biniaminov M, Rosner E, Rosenthal E, Gipsh N et al. Transformation of chronic lymphocytic leukemia to multiple myeloma: clonal evolution of second malignancy? Leukemia 1995; 9: 1974–1978.
Pfeifer D, Pantic M, Skatulla I, Rawluk J, Kreutz C, Martens UM et al. Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood 2007; 109: 1202–1210.
van den Berg A, Maggio E, Rust R, Kooistra K, Diepstra A, Poppema S . Clonal relation in a case of CLL, ALCL, and Hodgkin's composite lymphoma. Blood 2002; 100: 1425–1429.
Gonzalez D, van der Burg M, Garcia-Sanz R, Fenton JA, Langerak AW, Gonzalez M et al. Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma. Blood 2007; 110: 3112–3121.
Chang Y, Bosma MJ, Bosma GC . Extended duration of DH-JH rearrangement in immunoglobulin heavy chain transgenic mice: implications for regulation of allelic exclusion. J Exp Med 1999; 189: 1295–1305.
Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P . Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature 1981; 290: 368–372.
Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916.
Avet-Loiseau H, Attal M, Moreau P, Charbonnel C, Garban F, Hulin C et al. Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myelome. Blood 2007; 109: 3489–3495.
Xiong W, Wu X, Starnes S, Johnson SK, Haessler J, Wang S et al. An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma. Blood 2008; 112: 4235–4246.
Rachel JM, Zucker ML, Fox CM, Plapp FV, Menitove JE, Abbasi F et al. Monoclonal B-cell lymphocytosis in blood donors. Br J Haematol 2007; 139: 832–836.
Acknowledgements
We thank the anonymous internal and external reviewers for valuable comments and Dr Anke Spoo and Professor Dr Dr h.c. Roland Mertelsmann for fruitful discussions and continuous support. This article is dedicated to Professor Dr Norbert P Südkamp, Department of Orthopedic Surgery and Traumatology, Freiburg University Hospital, for his exceptional support, medical enthusiasm and thrive to best and innovatively treat his and our joint myeloma patients.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Pantic, M., Schroettner, P., Pfeifer, D. et al. Biclonal origin prevails in concomitant chronic lymphocytic leukemia and multiple myeloma. Leukemia 24, 885–890 (2010). https://doi.org/10.1038/leu.2009.294
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2009.294
This article is cited by
-
An unusual case of acute kidney injury in a patient with IgA paraproteinemia. Lessons for the clinical nephrologist
Journal of Nephrology (2022)
-
Sequential development of monoclonal B cell lymphocytosis-derived small lymphocytic lymphoma and plasma cell leukemia
Annals of Hematology (2018)
-
Concomitant Presence of Two Distinct Clones of Chronic Lymphocytic Leukemia and Plasma Cell Myeloma in a Patient
Indian Journal of Hematology and Blood Transfusion (2016)
-
Basisdiagnose, klinisches Spektrum von Plasmazellerkrankungen und Risikostratifizierung
Der Onkologe (2014)
-
B-Zell-Neoplasien mit plasmazellulärer und plasmablastischer Differenzierung
Der Pathologe (2013)